Notch3 signalling and vascular remodelling in pulmonary arterial hypertension

Influence of 2‐Methoxyestradiol and Sex on Hypoxia‐Induced Pulmonary Hypertension and Hypoxia‐Inducible Factor‐1‐α

(2019) Craig K. Docherty et al.   Journal of the American Heart Association

Exploration of the Notch3-HES5 signal pathway in monocrotaline-induced pulmonary hypertension using rat model

(2019) Xing Chen et al.   Congenital Heart Disease

Obesity Alters Oestrogen Metabolism and Contributes to Pulmonary Arterial Hypertension

(2019) Kirsty M. Mair et al.   EUROPEAN RESPIRATORY JOURNAL

A Potential Role for Exosomal TCTP Export in Vascular Remodeling in Pulmonary Arterial Hypertension

(2018) Elisabet Ferrer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Notch3ECD immunotherapy improves cerebrovascular responses in CADASIL mice

(2018) Lamia Ghezali et al.   ANNALS OF NEUROLOGY

mTORC1 pathway in DNA damage response

(2018) Yinxing Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Vascular smooth muscle contraction in hypertension

(2018) Rhian M Touyz et al.   CARDIOVASCULAR RESEARCH

Dynamic Ligand Discrimination in the Notch Signaling Pathway

(2018) Nagarajan Nandagopal et al.   CELL

A novel reporter allele for monitoringDll4expression within the embryonic and adult mouse

(2018) Alexander M. Herman et al.   Biology Open

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

(2018) Marc Humbert et al.   EUROPEAN RESPIRATORY JOURNAL

miRNA-206 regulates human pulmonary microvascular endothelial cell apoptosis via targeting in chronic obstructive pulmonary disease

(2018) Ying Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Estrogen receptor β–dependent Notch1 activation protects vascular endothelium against tumor necrosis factor α (TNFα)-induced apoptosis

(2017) Francesca Fortini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR-Notch3 signaling mediates pulmonary hypertension in hypoxia-exposed neonatal rats independent of changes in autophagy

(2017) Julijana Ivanovska et al.   PEDIATRIC PULMONOLOGY

Notch3 Maintains Luminal Phenotype and Suppresses Tumorigenesis and Metastasis of Breast Cancer via Trans-Activating Estrogen Receptor-α

(2017) Xiao-Wei Dou et al.   Theranostics

The cancer theory of pulmonary arterial hypertension

(2017) Olivier Boucherat et al.   Pulmonary Circulation

Prognostic Value of Follow-Up Hemodynamic Variables After Initial Management in Pulmonary Arterial Hypertension

(2017) Jason Weatherald et al.   CIRCULATION

KLF5 mediates vascular remodeling via HIF-1α in hypoxic pulmonary hypertension

(2016) Xiaochen Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

HIPPO–Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension

(2016) Tatiana V. Kudryashova et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension

(2016) Swati Dabral et al.   EUROPEAN RESPIRATORY JOURNAL

Loss of Notch3 Signaling in Vascular Smooth Muscle Cells Promotes Severe Heart Failure Upon HypertensionNovelty and Significance

(2016) Hélène Ragot et al.   HYPERTENSION

Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral ArteriesNovelty and Significance

(2016) Celine Baron-Menguy et al.   HYPERTENSION

DNA Damage and Pulmonary Hypertension

(2016) Benoît Ranchoux et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of role of Notch3 signaling pathway in human lung cancer cells

(2016) Wael Abdo Hassan et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension

(2015) Chiara Federici et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Notch Activation of Ca2+Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension

(2015) Kimberly A. Smith et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Oestrogen receptor alpha in pulmonary hypertension

(2015) Audrey F. Wright et al.   CARDIOVASCULAR RESEARCH

MicroRNA-143 Activation Regulates Smooth Muscle and Endothelial Cell Crosstalk in Pulmonary Arterial HypertensionNovelty and Significance

(2015) Lin Deng et al.   CIRCULATION RESEARCH

Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest

(2015) L. J. Manderfield et al.   DEVELOPMENT

Inhibition of Notch3 prevents monocrotaline-induced pulmonary arterial hypertension

(2015) Yonghong Zhang et al.   EXPERIMENTAL LUNG RESEARCH

Differential Regulation of NOTCH2 and NOTCH3 Contribute to Their Unique Functions in Vascular Smooth Muscle Cells

(2015) Jeremy T. Baeten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HES6 promotes prostate cancer aggressiveness independently of Notch signalling

(2015) Filipe L. F. Carvalho et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

microRNA-206 attenuates tumor proliferation and migration involving the downregulation of NOTCH3 in colorectal cancer

(2015) XIAO-WEI WANG et al.   ONCOLOGY REPORTS

Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase

(2015) Ying-Ju Lai et al.   PLoS One

Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca2+ entry in human pulmonary arterial smooth muscle cells

(2014) Hisao Yamamura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Notch3 Pathway Alterations in Ovarian Cancer

(2014) W. Hu et al.   CANCER RESEARCH

Proteomic Analysis Implicates Translationally Controlled Tumor Protein as a Novel Mediator of Occlusive Vascular Remodeling in Pulmonary Arterial Hypertension

(2014) Jessie R. Lavoie et al.   CIRCULATION

MicroRNA-206 overexpression promotes apoptosis, induces cell cycle arrest and inhibits the migration of human hepatocellular carcinoma HepG2 cells

(2014) WEIWEI LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

mTORC1 Is Involved in Hypoxia-Induced Pulmonary Hypertension Through the Activation of Notch3

(2014) Wang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of AKT signaling in DNA repair and clinical response to cancer therapy

(2014) Q. Liu et al.   NEURO-ONCOLOGY

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Thymosin Beta 4 Protects Mice from Monocrotaline-Induced Pulmonary Hypertension and Right Ventricular Hypertrophy

(2014) Chuanyu Wei et al.   PLoS One

STIM2 Contributes to Enhanced Store-Operated Ca2+ Entry in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension

(2014) Michael Y. Song et al.   Pulmonary Circulation

Mutations ofNOTCH3in childhood pulmonary arterial hypertension

(2014) Ayako Chida et al.   Molecular Genetics & Genomic Medicine

Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension

(2013) Amal Houssaini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Soluble Jagged1 Inhibits Pulmonary Hypertension by Attenuating Notch Signaling

(2013) Yongguang Xiao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pulmonary arterial hypertension: basis of sex differences in incidence and treatment response

(2013) K M Mair et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role for DNA Damage Signaling in Pulmonary Arterial Hypertension

(2013) Jolyane Meloche et al.   CIRCULATION

Notch3 induces epithelial–mesenchymal transition and attenuates carboplatin-induced apoptosis in ovarian cancer cells

(2013) Nidhi Gupta et al.   GYNECOLOGIC ONCOLOGY

Intrinsic Selectivity of Notch 1 for Delta-like 4 Over Delta-like 1

(2013) Marie Blanke Andrawes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch3 overexpression associates with poor prognosis in human non-small-cell lung cancer

(2013) Yuan-zi Ye et al.   MEDICAL ONCOLOGY

Targeting Notch signaling pathway in cancer: Clinical development advances and challenges

(2013) Naoko Takebe et al.   PHARMACOLOGY & THERAPEUTICS

17β-Estradiol Enhances Signalling Mediated by VEGF-A-Delta-Like Ligand 4-Notch1 Axis in Human Endothelial Cells

(2013) Cristiana Caliceti et al.   PLoS One

Regulation of Vascular Smooth Muscle Cell Phenotype in Three-Dimensional Coculture System by Jagged1-Selective Notch3 Signaling

(2013) Aparna Bhattacharyya et al.   TISSUE ENGINEERING PART A

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase

(2013) Isabel Serrano et al.   Nature Communications

Activity of the Estrogen-Metabolizing Enzyme Cytochrome P450 1B1 Influences the Development of Pulmonary Arterial Hypertension

(2012) Kevin White et al.   CIRCULATION

Mir-206 Regulates Pulmonary Artery Smooth Muscle Cell Proliferation and Differentiation

(2012) Samuel Jalali et al.   PLoS One

MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling

(2011) R. A. McDonald et al.   CARDIOVASCULAR RESEARCH

Activation of Endothelin-1 Receptor Signaling Pathways Is Associated With Neointima Formation, Neoangiogenesis and Irreversible Pulmonary Artery Hypertension in Patients With Congenital Heart Disease

(2011) HaiQiong Huang et al.   CIRCULATION JOURNAL

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia

(2011) Vera P. Krymskaya et al.   FASEB JOURNAL

Notch3 Is Essential for Regulation of the Renal Vascular Tone

(2011) Nada Boulos et al.   HYPERTENSION

Activation Dynamics and Signaling Properties of Notch3 Receptor in the Developing Pulmonary Artery

(2011) Shamik Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate

(2010) M. Morimoto et al.   JOURNAL OF CELL SCIENCE

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

(2010) Jianhui Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Direct Comparison of Dll1- and Dll4-Mediated Notch Activation Levels Shows Differential Lymphomyeloid Lineage Commitment Outcomes

(2010) M. Mohtashami et al.   JOURNAL OF IMMUNOLOGY

Notch Exhibits Ligand Bias and Maneuvers Stage-Specific Steering of Neural Differentiation in Embryonic Stem Cells

(2010) S. K. Ramasamy et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension

(2009) Aiko Ogawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer

(2009) Brenda Cohen et al.   BREAST CANCER RESEARCH AND TREATMENT

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

A hierarchical cascade activated by non-canonical Notch signaling and the mTOR–Rictor complex regulates neglect-induced death in mammalian cells

(2009) L R Perumalsamy et al.   CELL DEATH AND DIFFERENTIATION

Akt-dependent and -independent mechanisms of mTOR regulation in cancer

(2009) Regan M. Memmott et al.   CELLULAR SIGNALLING

NOTCH3 Expression Is Induced in Mural Cells Through an Autoregulatory Loop That Requires Endothelial-Expressed JAGGED1

(2009) Hua Liu et al.   CIRCULATION RESEARCH

Hey2 Regulation by FGF Provides a Notch-Independent Mechanism for Maintaining Pillar Cell Fate in the Organ of Corti

(2009) Angelika Doetzlhofer et al.   DEVELOPMENTAL CELL

Krüppel-like Factor 4 Inhibits Proliferation by Platelet-derived Growth Factor Receptor β-mediated, Not by Retinoic Acid Receptor α-mediated, Phosphatidylinositol 3-Kinase and ERK Signaling in Vascular Smooth Muscle Cells

(2009) Bin Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Notch updated

(2009) An-Chi Tien et al.   JOURNAL OF CELL BIOLOGY

Notch3 signaling promotes the development of pulmonary arterial hypertension

(2009) Xiaodong Li et al.   NATURE MEDICINE

Notch-1 activates estrogen receptor-α-dependent transcription via IKKα in breast cancer cells

(2009) L Hao et al.   ONCOGENE

KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract

(2008) Hai Zheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

(2008) I. Joshi et al.   BLOOD

Notch Inhibits Expression of the Kruppel-Like Factor 4 Tumor Suppressor in the Intestinal Epithelium

(2008) A. M. Ghaleb et al.   MOLECULAR CANCER RESEARCH

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE

Pathogenic mechanisms of pulmonary arterial hypertension

(2007) Stephen Y. Chan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

An overview of Notch3 function in vascular smooth muscle cells

(2007) Tao Wang et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY