Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase

Treatment of Graves Hyperthyroidism with Thionamides-Derived Drugs: Review

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Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

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Structural Biology of Presenilins and Signal Peptide Peptidases

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Potential novel targets for Alzheimer pharmacotherapy: II. Update on secretase inhibitors and related approaches

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Updated Treatment Algorithm of Pulmonary Arterial Hypertension

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Relevant Issues in the Pathology and Pathobiology of Pulmonary Hypertension

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Alzheimer culprits: Cellular crossroads and interplay

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Thyroid hormone is highly permissive in angioproliferative pulmonary hypertension in rats

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Pen-2 is dispensable for endoproteolysis of presenilin 1, and nicastrin-Aph subcomplex is important for both γ-secretase assembly and substrate recruitment

(2012) Guozhang Mao et al.   JOURNAL OF NEUROCHEMISTRY

CCN Notch Signaling in Vascular Smooth Muscle Cells

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Long-term response to calcium-channel blockers in non-idiopathic pulmonary arterial hypertension

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Activation and intrinsic  -secretase activity of presenilin 1

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Propylthiouracil, independent of its antithyroid effect, promotes vascular smooth muscle cells differentiation via PTEN induction

(2009) Wei-Jan Chen et al.   BASIC RESEARCH IN CARDIOLOGY

Propylthiouracil Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

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Notch3 signaling promotes the development of pulmonary arterial hypertension

(2009) Xiaodong Li et al.   NATURE MEDICINE

Evaluation of Pulmonary Artery Stiffness in Pulmonary Hypertension With Cardiac Magnetic Resonance

(2009) Javier Sanz et al.   JACC-Cardiovascular Imaging

Role of the Prostanoid EP4 Receptor in Iloprost-mediated Vasodilatation in Pulmonary Hypertension

(2008) Ying-Ju Lai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Propylthiouracil, independent of its antithyroid effect, decreases VSMC collagen expression

(2008) Wei-Jan Chen et al.   BASIC RESEARCH IN CARDIOLOGY

Notch and Vascular Smooth Muscle Cell Phenotype

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Molecular pathogenesis of pulmonary arterial hypertension

(2008) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Propylthiouracil, independent of its antithyroid effect, produces endothelium-dependent vasodilatation through induction of nitric oxide bioactivity

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