Protein Expression and Functional Relevance of Efflux and Uptake Drug Transporters at the Blood–Brain Barrier of Human Brain and Glioblastoma

LC–MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line

(2017) Laura Pelkonen et al.   MOLECULAR PHARMACEUTICS

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

(2017) Christine Wegler et al.   MOLECULAR PHARMACEUTICS

Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

(2017) Jann N Sarkaria et al.   NEURO-ONCOLOGY

Pilot PET Study to Assess the Functional Interplay Between ABCB1 and ABCG2 at the Human Blood-Brain Barrier

(2016) M Bauer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Extraction, Enrichment, Solubilization, and Digestion Techniques for Membrane Proteomics

(2016) Stephanie M. Moore et al.   JOURNAL OF PROTEOME RESEARCH

The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma

(2015) J. L. Pokorny et al.   CLINICAL CANCER RESEARCH

Blood-brain barrier: An impediment to neuropharmaceuticals

(2015) JT Henderson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Regulation of ABC transporters at the blood-brain barrier

(2015) DS Miller   CLINICAL PHARMACOLOGY & THERAPEUTICS

Optimized Approaches for Quantification of Drug Transporters in Tissues and Cells by MRM Proteomics

(2014) Bhagwat Prasad et al.   AAPS Journal

Transporters at CNS Barrier Sites: Obstacles or Opportunities for Drug Delivery?

(2014) Lucy Sanchez-Covarrubias et al.   CURRENT PHARMACEUTICAL DESIGN

Blood–brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics

(2014) Danica B Stanimirovic et al.   Expert Opinion on Drug Discovery

Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells

(2014) Stacey Watkins et al.   Nature Communications

Why Clinical Modulation of Efflux Transport at the Human Blood–Brain Barrier Is Unlikely: The ITC Evidence-Based Position

(2013) J C Kalvass et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Sources of Technical Variability in Quantitative LC–MS Proteomics: Human Brain Tissue Sample Analysis

(2013) Paul D. Piehowski et al.   JOURNAL OF PROTEOME RESEARCH

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Development of a multiplex UPLC-MRM MS method for quantification of human membrane transport proteins OATP1B1, OATP1B3 and OATP2B1 in in vitro systems and tissues

(2011) Chengjie Ji et al.   ANALYTICA CHIMICA ACTA

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

(2011) Ramzi Shawahna et al.   MOLECULAR PHARMACEUTICS

Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier

(2009) A. Ose et al.   DRUG METABOLISM AND DISPOSITION

An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N- -6-[5-( methyl)-2-furyl]-4-quinazolinamine; GW572016)

(2008) J. W. Polli et al.   DRUG METABOLISM AND DISPOSITION

Relationship between Drug/Metabolite Exposure and Impairment of Excretory Transport Function

(2008) M. J. Zamek-Gliszczynski et al.   DRUG METABOLISM AND DISPOSITION

Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport

(2008) S. Syvanen et al.   DRUG METABOLISM AND DISPOSITION

Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria

(2008) Junichi Kamiie et al.   PHARMACEUTICAL RESEARCH