Why Clinical Modulation of Efflux Transport at the Human Blood–Brain Barrier Is Unlikely: The ITC Evidence-Based Position

Loperamide and P-glycoprotein inhibition: assessment of the clinical relevance

(2015) Joris Vandenbossche et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Highlights from the International Transporter Consortium Second Workshop

(2012) M J Zamek-Gliszczynski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

P-Glycoprotein-Based Loperamide–Cyclosporine Drug Interaction at the Rat Blood–Brain Barrier: Prediction from In Vitro Studies and Extrapolation to Humans

(2012) Peng Hsiao et al.   MOLECULAR PHARMACEUTICS

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain

(2012) R. E. Cannon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood–brain barrier P-glycoprotein function in Alzheimer's disease

(2011) Daniëlle M. E. van Assema et al.   BRAIN

Pgp-Mediated Interaction Between (R)-[11C]Verapamil and Tariquidar at the Human Blood–Brain Barrier: A Comparison With Rat Data

(2011) M Bauer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Molecular Biology of Nucleoside Transporters and their Distributions and Functions in the Brain

(2011) Fiona E. Parkinson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

In Vitro Blood–Brain Barrier Models: Current and Perspective Technologies

(2011) Pooja Naik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Quantitative Evaluation of the Impact of Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier on the Predictability of the Unbound Concentrations of Drugs in the Brain Using Cerebrospinal Fluid Concentration as a Surrogate

(2011) H. Kodaira et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Vincristine-induced central neurotoxicity in a collie homozygous for the ABCB1Δ mutation

(2011) L. Krugman et al.   JOURNAL OF SMALL ANIMAL PRACTICE

Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels

(2011) Ramzi Shawahna et al.   MOLECULAR PHARMACEUTICS

Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

(2011) Andy CRUMP et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Functions of OATP1A and 1B transporters in vivo: insights from mouse models

(2011) Dilek Iusuf et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Full efficacy with no CNS side-effects: unachievable panacea or reality? DMPK considerations in design of drugs with limited brain penetration

(2011) Susan Cole et al.   XENOBIOTICA

The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance

(2011) Katherine S. Fenner et al.   XENOBIOTICA

P-Glycoprotein Function at the Blood-Brain Barrier in Humans Can Be Quantified with the Substrate Radiotracer 11C-N-Desmethyl-Loperamide

(2010) W. C. Kreisl et al.   JOURNAL OF NUCLEAR MEDICINE

Biodistribution and Uptake of 3'-Deoxy-3'-Fluorothymidine in ENT1-Knockout Mice and in an ENT1-Knockdown Tumor Model

(2010) R. J. Paproski et al.   JOURNAL OF NUCLEAR MEDICINE

Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone

(2010) H. Kodaira et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Imaging the Function of P-Glycoprotein With Radiotracers: Pharmacokinetics and In Vivo Applications

(2009) P Kannan et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Breast Cancer Resistance Protein Interacts with Various Compounds in Vitro, but Plays a Minor Role in Substrate Efflux at the Blood-Brain Barrier

(2009) R. Zhao et al.   DRUG METABOLISM AND DISPOSITION

Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier

(2009) A. Ose et al.   DRUG METABOLISM AND DISPOSITION

Drug interactions at the blood-brain barrier: Fact or fantasy?☆

(2009) Sara Eyal et al.   PHARMACOLOGY & THERAPEUTICS

An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N- -6-[5-( methyl)-2-furyl]-4-quinazolinamine; GW572016)

(2008) J. W. Polli et al.   DRUG METABOLISM AND DISPOSITION

Relationship between Drug/Metabolite Exposure and Impairment of Excretory Transport Function

(2008) M. J. Zamek-Gliszczynski et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2

(2008) Eva M. del Amo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of P‐Glycoprotein Expression Levels on the Concentration‐Dependent Permeability of Drugs to the Cell Membrane

(2007) Yoshiyuki Shirasaka et al.   JOURNAL OF PHARMACEUTICAL SCIENCES