Article
Materials Science, Multidisciplinary
Yi Shan, Nilofer Sayed, Kok Chan Chong, Hui Jun Ting, Xianglong Liu, Bowen Li, Jingjing Liu, Min Wu, Jiong-Wei Wang, Bin Liu
Summary: Nonalcoholic steatohepatitis (NASH) is a common disease worldwide, with potential progression to fibrosis, cirrhosis, and hepatocellular carcinoma. This study developed an activatable imaging probe TPAH to monitor fibrosis progression in NASH, showing promising specificity.
ACS MATERIALS LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Sandra Ferreira, Nuno Saraiva, Patricia Rijo, Ana S. Fernandes
Summary: LOX and LOXL2 are amine oxidases that catalyze cross-linking reactions of elastin and collagen in connective tissue, with LOXL2 showing high expression in certain tumors. Inhibition of LOX and LOXL2 is considered a promising strategy for preventing metastasis and invasion of breast cancer. Novel synthetic compounds acting as selective inhibitors for LOX/LOXL2 or dual LOX/LOXL inhibitors have been developed, showing potential for effective therapeutic approaches in breast cancer treatment.
Article
Biochemistry & Molecular Biology
Ji-Wei Jiao, Xiu-Hui Zhan, Juan-Juan Wang, Li-Xia He, Zhen-Chang Guo, Xiu-E Xu, Lian-Di Liao, Xin Huang, Bing Wen, Yi-Wei Xu, Hai Hu, Gera Neufeld, Zhi-Jie Chang, Kai Zhang, Li-Yan Xu, En-Min Li
Summary: The study reveals that LOXL2 and its L2A13 variant can enhance glucose metabolism, cell proliferation, and tumor development in esophageal cancer. Additionally, LOXL2 and L2A13 directly activate glycolytic enzymes, leading to metabolic reprogramming and tumor progression.
Article
Chemistry, Multidisciplinary
Gokhan Bahcecioglu, Xiaoshan Yue, Erin Howe, Ian Guldner, M. Sharon Stack, Harikrishna Nakshatri, Siyuan Zhang, Pinar Zorlutuna
Summary: The study reveals that aging ECM can drive normal mammary epithelial cells to a more invasive and cancer-like phenotype, and enhance motility and invasiveness in breast cancer cells. Different responses of cells to young and aged ECMs may lead to the identification of new targets for cancer treatment and prevention.
Article
Multidisciplinary Sciences
Qixin Wang, Isaac Kirubakaran Sundar, Joseph H. Lucas, Jun-Gyu Park, Aitor Nogales, Luis Martinez-Sobrido, Irfan Rahman
Summary: The molecular clock REV-ERB alpha plays a central role in regulating lung injuries and its decreased abundance exacerbates fibrotic progression. This study reveals that REV-ERB alpha interacts with the lysyl oxidase-collagen axis during fibrogenesis and demonstrates the therapeutic potential of Rev-erb alpha agonist against lung fibrosis.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Xuanrong Chen, Yi Shao, Wanqing Wei, Haishan Shen, Yang Li, Yutong Chen, Qianwang Ma, Hanlin Li, Zhao Yang, Yuanjie Niu, Zhiqun Shang
Summary: The role of lysyl oxidase (LOX) in prostate cancer is controversial, but low LOX expression contributes to the progression of CRPC by upregulating IGFBP3. Restoring LOX expression may inhibit the progression of CRPC, suggesting LOX as a promising therapeutic target in PCa.
Article
Pharmacology & Pharmacy
Sofia Ramos, Sandra Ferreira, Ana S. Fernandes, Nuno Saraiva
Summary: LOX and LOXL1-4 are enzymes that catalyze the cross-linking of elastin and collagen, potentially facilitating breast cancer metastasis. This study explores the role of each LOX in breast cancer and finds that LOXL2 is an important biomarker and therapeutic target, while LOXL3 and LOXL4 have different expression profiles compared to LOX, LOXL1, and LOXL2.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alfonso Bolado-Carrancio, Martin Lee, Ailith Ewing, Morwenna Muir, Kenneth G. Macleod, William M. Gallagher, Lan K. Nguyen, Neil O. Carragher, Colin A. Semple, Valerie G. Brunton, Patrick T. Caswell, Alex von Kriegsheim
Summary: ISG15 modifies GDI2 through ISGylation to alter EGFR trafficking, enhance Akt signaling, and drive more aggressive tumor behavior in human breast cancer.
Article
Oncology
Lumin Wang, Yi Gao, Dongdong Tong, Xiaofei Wang, Chen Guo, Bo Guo, Yang Yang, Lingyu Zhao, Jing Zhang, Juan Yang, Yannan Qin, Liying Liu, Chen Huang
Summary: The study revealed the function of the MeCP2/HOXD3/HB-EGF regulatory axis in HCC, providing insights for the development of targeted therapeutics and potential biomarkers. The expression of HOXD3 gene is regulated by the cooperative action of MeCP2 and CREB1, leading to promotion of HCC metastasis, invasion, and angiogenesis.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Sylvain D. Vallet, Coline Berthollier, Romain Salza, Laurent Muller, Sylvie Ricard-Blum
Summary: The study aimed to build and analyze the interaction network of the LOX family members, identifying rewiring in cancer. Computational analyses revealed the network's involvement in various cellular processes and its functional switch in colorectal carcinoma.
Article
Oncology
Ni Luh Gede Yoni Komalasari, Nahoko Tomonobu, Rie Kinoshita, Youyi Chen, Yoshihiko Sakaguchi, Yuma Gohara, Fan Jiang, Ken-ich Yamamoto, Hitoshi Murata, I. Made Winarsa Ruma, I. Wayan Sumardika, Jin Zhou, Akira Yamauchi, Futoshi Kuribayashi, Yusuke Inoue, Shinichi Toyooka, Masakiyo Sakaguchi
Summary: LOXL4 is upregulated in breast cancer cells and interacts with annexin A2 and integrin beta-1 to promote breast cancer progression.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yibo Fan, Yuan Li, Xiaodan Yao, Jiangkang Jin, Ailing Scott, Bovey Liu, Shan Wang, Longfei Huo, Ying Wang, Ruiping Wang, Melissa Pool Pizzi, Lang Ma, Shan Shao, Matheus Sewastjanow-Silva, Rebecca Waters, Deyali Chatterjee, Bin Liu, Namita Shanbhag, Guang Peng, George Adrian Calin, Pawel Karol Mazur, Samir M. Hanash, Jo Ishizawa, Yuki Hirata, Osamu Nagano, Zhenning Wang, Linghua Wang, Wa Xian, Frank McKeon, Jaffer A. Ajani, Shumei Song
Summary: SOX9 plays a critical role in suppressing CD8(+) T cell responses and modifying macrophage function in GAC through the paracrine factor LIF. Targeting both LIF/LIFR and CSF1R has potential for combination therapy against advanced GAC, targeting SOX9-mediated cancer stemness, T cell immunosuppression, and metastasis.
Article
Oncology
Seung-Mo Kim, Eun-Jung Lim, Ki-Chun Yoo, Yi Zhao, Jae-Hyeok Kang, Eun-Ji Lim, Incheol Shin, Seok-Gu Kang, Han Woong Lim, Su-Jae Lee
Summary: This study investigates the molecular mechanisms of ECM remodeling and the interaction between GBM-educated MSLCs and GBMs in tumor progression. The findings provide mechanistic insights into the pro-infiltrative tumor microenvironment and highlight a potential therapeutic target for suppressing GBM infiltration.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jia-Yi Zhang, Wei-Wen Zhu, Meng-Yao Wang, Run-Dong Zhai, Qiong Wang, Wei-Li Shen, Lai-Kui Liu
Summary: Our study reveals that the high expression of LOX in CAFs can affect proliferation, migration, invasion, and EMT process of tumor cells, promoting the development of OSCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Kathrin Hedegger, Andreas Blutke, Theresa Hommel, Kerstin E. E. Auer, Nishanth B. B. Nataraj, Moshit Lindzen, Yosef Yarden, Maik Dahlhoff
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly deadly cancer, and targeted therapies for PDAC are still under development. This study shows that simultaneously blocking the entire ERBB receptor family, using a molecular decoy called TRAP-F-C, can effectively reduce pancreatic tumor burden and RAS activity in a mouse model of PDAC.
MOLECULAR ONCOLOGY
(2023)
Article
Chemistry, Medicinal
Deborah A. Smithen, Leo M. H. Leung, Mairi Challinor, Rae Lawrence, HaoRan Tang, Dan Niculescu-Duvaz, Simon P. Pearce, Robert Mcleary, Filipa Lopes, Mohammed Aljarah, Michael Brown, Louise Johnson, Graeme Thomson, Richard Marais, Caroline Springer
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Dermatology
M. Lotz, T. Budden, S. J. Furney, A. Viros
Summary: This study establishes a mathematical approach using melanoma mutational data to analyze how sex and age shape the tumor genome. The results show that melanoma is primarily driven by cell-intrinsic age-related mutations and extrinsic ultraviolet radiation-induced mutations, with differences in magnitude and chronology by sex in distinct molecular subtypes. Sex and age play a role in determining the final mutational composition of melanoma.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Chemistry, Applied
Michael Brown, Mohammed Aljarah, Hannah Asiki, Leo M. H. Leung, Deborah A. Smithen, Natalie Miller, Gabor Nemeth, Lawrence Davies, Dan Niculescu-Duvaz, Alfonso Zambon, Caroline Springer
Summary: The scale-up of a chiral bicyclic homopiperazine of pharmaceutical interest was improved using continuous-flow chemistry, with enhancements in outcome and safety profile of a key batch ring-expansion step. The selectivity of nitrogen insertion for the ring expansion was enhanced via an alternative photochemical oxaziridine rearrangement under mild conditions, leading to the first photochemical scale-up of a homopiperazine in a simple and efficient flow reactor.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Oncology
Rebecca Jane Lee, Garima Khandelwal, Franziska Baenke, Alessio Cannistraci, Kenneth Macleod, Piyushkumar Mundra, Garry Ashton, Amit Mandal, Amaya Viros, Gabriela Gremel, Elena Galvani, Matthew Smith, Neil Carragher, Nathalie Dhomen, Crispin Miller, Paul Lorigan, Richard Marais
Article
Oncology
G. Saturno, F. Lopes, I Niculescu-Duvaz, D. Niculescu-Duvaz, A. Zambon, L. Davies, L. Johnson, N. Preece, R. Lee, A. Viros, D. Holovanchuk, M. Pedersen, R. McLeary, P. Lorigan, N. Dhomen, C. Fisher, U. Banerji, E. Dean, M. G. Krebs, M. Gore, J. Larkin, R. Marais, C. Springer
Summary: KRAS mutations are common in various cancers, and the new drug CCT3833 has shown promising preclinical therapeutic efficacy in targeting these mutations, indicating a potential treatment option for KRAS-mutant tumors.
ANNALS OF ONCOLOGY
(2021)
Article
Oncology
Barrie Peck, Philip Bland, Ioanna Mavrommati, Gareth Muirhead, Hannah Cottom, Patty T. Wai, Sarah L. Maguire, Holly E. Barker, Eamonn Morrison, Divya Kriplani, Lu Yu, Amy Gibson, Giulia Falgari, Keith Brennan, Gillian Farnie, Richard Buus, Rebecca Marlow, Daniela Novo, Eleanor Knight, Naomi Guppy, Daniela Kolarevic, Snezana Susnjar, Natasa Medic Milijic, Kalnisha Naidoo, Patrycja Gazinska, Ioannis Roxanis, Sunil Pancholi, Lesley-Ann Martin, Erle M. Holgersen, Maggie C. U. Cheang, Farzana Noor, Sophie Postel-Vinay, Gerard Quinn, Simon McDade, Lukas Krasny, Paul Huang, Frances Daley, Fredrik Wallberg, Jyoti S. Choudhary, Syed Haider, Andrew N. Tutt, Rachael Natrajan
Summary: This study highlights the identification of CREBBP as a novel driver in aggressive TNBC, with associated genetic vulnerability in tumor cells with alterations in CREBBP, and provides a preclinical rationale for assessing CREBBP alterations as a biomarker of CDK4/6 inhibitor response in a new patient population. Targeting CREBBP alterations with clinical CDK4/6 inhibitors selectively impairs growth in spheroids, cell line xenografts, and patient-derived models from multiple tumor types.
Article
Oncology
Timothy Budden, Caroline Gaudy-Marqueste, Sarah Craig, Yuan Hu, Charles H. Earnshaw, Shilpa Gurung, Amelle Ra, Victoria Akhras, Patrick Shenjere, Ruth Green, Lynne Jamieson, John Lear, Luisa Motta, Carlos Caulin, Deemesh Oudit, Simon J. Furney, Amaya Viros
Summary: This study demonstrates that cSCC is more aggressive in men, while immunocompetent women develop mild cSCC later in life. The research also shows that female immunity offers greater protection than male immunity against cSCC.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Timothy Budden, Caroline Gaudy-Marqueste, Andrew Porter, Emily Kay, Shilpa Gurung, Charles H. Earnshaw, Katharina Roeck, Sarah Craig, Victor Traves, Jean Krutmann, Patricia Muller, Luisa Motta, Sara Zanivan, Angeliki Malliri, Simon J. Furney, Eduardo Nagore, Amaya Viros
Summary: Ultraviolet radiation (UVR) damages dermal fibroblasts, leading to reduced melanoma invasion; aged primary melanomas in skin with degraded collagen have a better prognosis; while new collagen synthesis restores melanoma invasion and leads to worsened outcome.
NATURE COMMUNICATIONS
(2021)
Article
Dermatology
Caroline Gaudy-Marqueste, Nicolas Macagno, Anderson Loundou, Eric Pellegrino, L'houcine Ouafik, Timothy Budden, Piyushkumar Mundra, Gabriela Gremel, Victoria Akhras, Lijing Lin, Martin Cook, Rajiv Kumar, Jean-Jacques Grob, Eduardo Nagore, Richard Marais, Amaya Viros
Summary: This study investigates the stratification of primary cutaneous melanomas with a thickness >= 1 mm based on their rate of growth, and comprehensively explores their epidemiologic, clinical, and mutational profiles. The results indicate that fast-growing melanomas are associated with specific tumor biology and environmental factors.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
David Millan-Esteban, Zaida Garcia-Casado, Esperanza Manrique-Silva, Amaya Viros, Rajiv Kumar, Simon Furney, Jose Antonio Lopez-Guerrero, Celia Requena, Jose Banuls, Victor Traves, Eduardo Nagore
Summary: KIT mutations are more frequent in acral and mucosal melanomas compared to non-acral cutaneous melanomas. These mutations are associated with aggressive melanomas characterized by ulceration, vascular invasiveness, and increased Breslow thickness, but not necessarily related to the development of nevi or chronic sun damage.
EUROPEAN JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
C. C. Darmawan, J. Ohn, J. -H. Mun, S. Kim, Y. Lim, S. J. Jo, Y. -G. Kim, B. Kim, M. -W. Seong, B. J. Kim, C. Lee, Y. Kwak, H. J. Chung, A. Viros, D. Y. Lee
Summary: Nail melanoma (NM) is a challenging differential diagnosis for patients with longitudinal melanonychia. Clinical and histopathological analyses are essential for accurate diagnosis, and surgery is the primary treatment. Targeted therapy and immunotherapy may be considered for advanced stages of NM.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Oncology
David Millan-Esteban, Maria Pena-Chilet, Zaida Garcia-Casado, Esperanza Manrique-Silva, Celia Requena, Jose Banuls, Jose Antonio Lopez-Guerrero, Aranzazu Rodriguez-Hernandez, Victor Traves, Joaquin Dopazo, Amaya Viros, Rajiv Kumar, Eduardo Nagore
Summary: The divergent pathway model suggests that cutaneous melanoma can be divided into two groups - one with a propensity for melanocyte proliferation and the other associated with cumulative solar damage. Molecular profiling using sequencing and bioinformatics tools revealed that nevogenic melanomas had mutations in BRAF, while CSD melanomas had mutations in NF1, ROS1, GNA11, and RAC1. This study concludes that nevogenic and CSD melanomas are distinct biological entities with implications for targeted therapies.
Review
Oncology
Samantha Fernandes, Cian Vyas, Peggy Lim, Ruben F. Pereira, Amaya Viros, Paulo Bartolo
Summary: Melanoma, a potentially fatal cancer, has been increasing in incidence over the past 50 years due to excessive sun exposure and ultraviolet radiation. With the highest incidence in people of European descent and the aging population, melanoma is influenced by various clinical and epidemiological factors such as sex, ethnicity, UV exposure, anatomic site, and age. Although improvements in targeted and immunotherapies have led to better survival rates, advancing our understanding of melanoma biology and disease progression is crucial for improving clinical outcomes. The development of three-dimensional human skin equivalents using biofabrication techniques, like bioprinting, offers a promising approach to unravel the complexity of melanoma and associated risk factors. These 3D skin models can serve as a platform for personalized and therapeutic testing.
Article
Oncology
Sara Valpione, Elena Galvani, Joshua Tweedy, Piyushkumar A. Mundra, Antonia Banyard, Philippa Middlehurst, Jeff Barry, Sarah Mills, Zena Salih, John Weightman, Avinash Gupta, Gabriela Gremel, Franziska Baenke, Nathalie Dhomen, Paul C. Lorigan, Richard Marais