Determinants of amyloid fibril degradation by the PDZ protease HTRA1

The Autolysis of Human HtrA1 Is Governed by the Redox State of Its N-Terminal Domain

(2014) Michael W. Risør et al.   BIOCHEMISTRY

Impact of Age on the Cerebrovascular Proteomes of Wild-Type and Tg-SwDI Mice

(2014) James L. Searcy et al.   PLoS One

The Emerging Roles of HTRA1 in Musculoskeletal Disease

(2013) André Nicki Tiaden et al.   AMERICAN JOURNAL OF PATHOLOGY

Aggregation of amyloids in a cellular context: modelling and experiment

(2013) Ran Friedman   BIOCHEMICAL JOURNAL

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Nonamyloid Clients

(2012) Morgan E. DeSantis et al.   CELL

Human High Temperature Requirement Serine Protease A1 (HTRA1) Degrades Tau Protein Aggregates

(2012) Annette Tennstaedt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ

(2012) Hélène Malet et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Spread of Neurodegenerative Disease

(2012) John Hardy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural and Functional Analysis of HtrA1 and Its Subdomains

(2012) Charles Eigenbrot et al.   STRUCTURE

The Dynamic Structure of Filamentous Tau

(2011) Stefan Bibow et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene

(2011) Henrik Karring et al.   EXPERIMENTAL EYE RESEARCH

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies

(2011) Yoshinari Miyata et al.   Future Medicinal Chemistry

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultra High Resolution Linear Ion Trap Orbitrap Mass Spectrometer (Orbitrap Elite) Facilitates Top Down LC MS/MS and Versatile Peptide Fragmentation Modes

(2011) Annette Michalski et al.   MOLECULAR & CELLULAR PROTEOMICS

HTRA proteases: regulated proteolysis in protein quality control

(2011) Tim Clausen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Substrate-induced remodeling of the active site regulates human HTRA1 activity

(2011) Linda Truebestein et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Overexpression of HTRA1 Leads to Ultrastructural Changes in the Elastic Layer of Bruch's Membrane via Cleavage of Extracellular Matrix Components

(2011) Sarah Vierkotten et al.   PLoS One

Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice

(2011) A. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of ubiquitin–proteasome-mediated proteolysis in nervous system disease

(2010) Ashok N. Hegde et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

The Serine Protease HtrA1 Specifically Interacts and Degrades the Tuberous Sclerosis Complex 2 Protein

(2010) M. Campioni et al.   MOLECULAR CANCER RESEARCH

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit

(2010) Peera Jaru-Ampornpan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Determinants of structural and functional plasticity of a widely conserved protease chaperone complex

(2010) Melisa Merdanovic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Towards revealing the structure of bacterial inclusion bodies

(2010) Lei Wang   Prion

HtrA Serine Proteases as Potential Therapeutic Targets in Cancer

(2009) Jeremy Chien et al.   CURRENT CANCER DRUG TARGETS

Identification of a Novel HtrA1-susceptible Cleavage Site in Human Aggrecan

(2009) Angela Chamberland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening

(2009) Jeremy Chien et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Serine Protease HtrA1 Associates with Microtubules and Inhibits Cell Migration

(2009) J. Chien et al.   MOLECULAR AND CELLULAR BIOLOGY

Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease

(2009) Kenju Hara et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

Allosteric Activation of HtrA Protease DegP by Stress Signals during Bacterial Protein Quality Control

(2008) Michael Meltzer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Emerging roles of serine proteinases in tissue turnover in arthritis

(2008) J. M. Milner et al.   ARTHRITIS AND RHEUMATISM

Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins

(2008) Gary A. Clawson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Structural basis for the regulated protease and chaperone function of DegP

(2008) Tobias Krojer et al.   NATURE

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

(2008) T. Krojer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA