Review: Targeting the Transforming Growth Factor-Beta Pathway in Ovarian Cancer

Phase I trial of Vigil® personalized engineered autologous tumor cells (EATC) in ovarian cancer

(2018) R.P. Rocconi et al.   GYNECOLOGIC ONCOLOGY

Distinct DNA Methylation Profiles in Ovarian Tumors: Opportunities for Novel Biomarkers

(2018) Lorena Losi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

(2018) Yan Lan et al.   Science Translational Medicine

Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy

(2018) Rajani Ravi et al.   Nature Communications

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

(2018) Rikke B. Holmgaard et al.   Journal for ImmunoTherapy of Cancer

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

LY2157299 Monohydrate, a TGF-βR1 Inhibitor, Suppresses Tumor Growth and Ascites Development in Ovarian Cancer

(2018) Qing Zhang et al.   Cancers

Blockade of TGF-β signaling with novel synthetic antibodies limits immune exclusion and improves chemotherapy response in metastatic ovarian cancer models

(2018) Daniel Newsted et al.   OncoImmunology

Transforming growth factor-β: A therapeutic target for cancer

(2017) Sulsal Haque et al.   Human Vaccines & Immunotherapeutics

TGF-β Inhibition Improves Oncolytic Herpes Viroimmunotherapy in Murine Models of Rhabdomyosarcoma

(2017) Brian Hutzen et al.   Molecular Therapy-Oncolytics

Immune checkpoint inhibition in ovarian cancer

(2016) Junzo Hamanishi et al.   INTERNATIONAL IMMUNOLOGY

CD4 + CD25 + regulatory T cells in tumor immunity

(2016) Xin Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels

(2016) Elisenda Alsina-Sanchis et al.   INTERNATIONAL JOURNAL OF CANCER

T-regulatory cells as part of strategy of immune evasion by pathogens

(2015) F. Yu. Garib et al.   BIOCHEMISTRY-MOSCOW

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

(2015) Claire Vanpouille-Box et al.   CANCER RESEARCH

Targeting the TGFβ pathway for cancer therapy

(2015) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

TGF-beta Signaling in Cancer Treatment

(2014) Isabel Fabregat et al.   CURRENT PHARMACEUTICAL DESIGN

Risk Prediction for Late-Stage Ovarian Cancer by Meta-analysis of 1525 Patient Samples

(2014) Markus Riester et al.   JNCI-Journal of the National Cancer Institute

Summary of bi-shRNAfurin/GM-CSF Augmented Autologous Tumor Cell Immunotherapy (FANG™) in Advanced Cancer of the Liver

(2014) John Nemunaitis et al.   ONCOLOGY

FOXL2, GATA4, and SMAD3 Co-Operatively Modulate Gene Expression, Cell Viability and Apoptosis in Ovarian Granulosa Cell Tumor Cells

(2014) Mikko Anttonen et al.   PLoS One

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy

(2013) Yhun Yhong Sheen et al.   Biomolecules & Therapeutics

TGF-  Modulates Ovarian Cancer Invasion by Upregulating CAF-Derived Versican in the Tumor Microenvironment

(2013) T.-L. Yeung et al.   CANCER RESEARCH

A Collagen-Remodeling Gene Signature Regulated by TGF-β Signaling Is Associated with Metastasis and Poor Survival in Serous Ovarian Cancer

(2013) Dong-Joo Cheon et al.   CLINICAL CANCER RESEARCH

Essential but differential role of FOXL2wt and FOXL2C134W in GDF-9 stimulation of follistatin transcription in co-operation with Smad3 in the human granulosa cell line COV434

(2013) David Nonis et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

TGF-β signalling and its role in cancer progression and metastasis

(2012) Yvette Drabsch et al.   CANCER AND METASTASIS REVIEWS

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor

(2012) Long Zhang et al.   NATURE CELL BIOLOGY

Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

(2012) Jason Park et al.   NATURE MATERIALS

The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis

(2011) Kendra Garrison et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Outgrowth of Drug-Resistant Carcinomas Expressing Markers of Tumor Aggression after Long-term T RI/II Kinase Inhibition with LY2109761

(2011) E. C. Connolly et al.   CANCER RESEARCH

Phase I Trial of TGF- 2 Antisense GM-CSF Gene-Modified Autologous Tumor Cell (TAG) Vaccine

(2011) J. Olivares et al.   CLINICAL CANCER RESEARCH

TGF-β Blockade Controls Ascites by Preventing Abnormalization of Lymphatic Vessels in Orthotopic Human Ovarian Carcinoma Models

(2011) Shan Liao et al.   CLINICAL CANCER RESEARCH

The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer

(2011) Shogo Yamamura et al.   INTERNATIONAL JOURNAL OF CANCER

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

(2011) Yabing Mu et al.   Nature Communications

The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory

(2010) Robert J. Kurman et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Transforming growth factor-β and the hallmarks of cancer

(2010) Maozhen Tian et al.   CELLULAR SIGNALLING

Anti-Transforming Growth Factor   Receptor II Antibody Has Therapeutic Efficacy against Primary Tumor Growth and Metastasis through Multieffects on Cancer, Stroma, and Immune Cells

(2010) Z. Zhong et al.   CLINICAL CANCER RESEARCH

Ovarian cancer creates a suppressive microenvironment to escape immune elimination

(2010) Refika Yigit et al.   GYNECOLOGIC ONCOLOGY

Changing the Paradigm in the Treatment of Platinum-Sensitive Recurrent Ovarian Cancer

(2010) Bradley J. Monk et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasis

(2010) Vidya Ganapathy et al.   Molecular Cancer

Targeted therapy for high-grade glioma with the TGF- 2 inhibitor trabedersen: results of a randomized and controlled phase IIb study

(2010) U. Bogdahn et al.   NEURO-ONCOLOGY

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

(2010) Li Yang et al.   TRENDS IN IMMUNOLOGY

Epithelial–mesenchymal transition in ovarian cancer

(2009) Daniele Vergara et al.   CANCER LETTERS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Synergistic Enhancement of CD8+ T Cell-Mediated Tumor Vaccine Efficacy by an Anti-Transforming Growth Factor-  Monoclonal Antibody

(2009) M. Terabe et al.   CLINICAL CANCER RESEARCH

Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition

(2009) Carl-Henrik Heldin et al.   CURRENT OPINION IN CELL BIOLOGY

TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

(2009) Mary Y. Wu et al.   DEVELOPMENTAL CELL

Smad1-Smad5Ovarian Conditional Knockout Mice Develop a Disease Profile Similar to the Juvenile Form of Human Granulosa Cell Tumors

(2009) Brooke S. Middlebrook et al.   ENDOCRINOLOGY

Changes in expression, and/or mutations in TGF-β receptors (TGF-β RI and TGF-β RII) and Smad 4 in human ovarian tumors

(2009) Marie Lue Antony et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Ovarian cancer cytoreduction induces changes in T cell population subsets reducing immunosuppression

(2009) Chiara Napoletano et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mutation ofFOXL2in Granulosa-Cell Tumors of the Ovary

(2009) Sohrab P. Shah et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Role of transforming growth factor-β superfamily signaling pathways in human disease

(2008) Kelly J. Gordon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer

(2008) Ninke Leffers et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

An Anti-Transforming Growth Factor   Antibody Suppresses Metastasis via Cooperative Effects on Multiple Cell Compartments

(2008) J.-S. Nam et al.   CANCER RESEARCH

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

Early Events in the Pathogenesis of Epithelial Ovarian Cancer

(2008) Charles N. Landen et al.   JOURNAL OF CLINICAL ONCOLOGY