Epidermal ROCK2 induces AKT1/GSK3β/β-catenin, NFκB and dermal tenascin C; but enhanced differentiation and p53/p21 inhibit papilloma

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

(2018) Mathieu Unbekandt et al.   CANCER RESEARCH

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

(2017) Thiviyani Maruthappu et al.   Nature Communications

SnapShot: Mechanosensing Matrix

(2016) Jerome Irianto et al.   CELL

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein

(2016) Michael S. Samuel et al.   GENESIS

ROCK2/ras Ha co-operation induces malignant conversion via p53 loss, elevated NF-κB and tenascin C-associated rigidity, but p21 inhibits ROCK2/NF-κB-mediated progression

(2016) S F Masre et al.   ONCOGENE

Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

(2016) Beate M. Lichtenberger et al.   Nature Communications

Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

(2016) Sandra Kümper et al.   eLife

Tenascin-C induces resistance to apoptosis in pancreatic cancer cell through activation of ERK/NF-κB pathway

(2015) Meiyan Shi et al.   APOPTOSIS

p21 Ablation in Liver Enhances DNA Damage, Cholestasis, and Carcinogenesis

(2015) H. Ehedego et al.   CANCER RESEARCH

Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression

(2015) V. R. Mittapalli et al.   CANCER RESEARCH

Tenascin-C Protects Cancer Stem-like Cells from Immune Surveillance by Arresting T-cell Activation

(2015) E. Jachetti et al.   CANCER RESEARCH

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis

(2015) Jasreen Kular et al.   DEVELOPMENTAL CELL

Human keratinocytes have two interconvertible modes of proliferation

(2015) Amit Roshan et al.   NATURE CELL BIOLOGY

Tenascin C in metastasis: A view from the invasive front

(2015) Camille M Lowy et al.   Cell Adhesion & Migration

PTEN ablation in Ras Ha /Fos skin carcinogenesis invokes p53-dependent p21 to delay conversion while p53-independent p21 limits progression via cyclin D1/E2 inhibition

(2013) F H Macdonald et al.   ONCOGENE

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins

(2013) J. Seong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

(2012) Nicola Rath et al.   EMBO REPORTS

Differential Regulation of Adhesion Complex Turnover by ROCK1 and ROCK2

(2012) Frances E. Lock et al.   PLoS One

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Reprogramming adult dermis to a neonatal state through epidermal activation of  -catenin

(2011) C. A. Collins et al.   DEVELOPMENT

Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis

(2011) Cory L. Simpson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FAK Deletion Promotes p53-Mediated Induction of p21, DNA-Damage Responses and Radio-Resistance in Advanced Squamous Cancer Cells

(2011) Kathryn Graham et al.   PLoS One

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

(2010) Gabrielle H. Ashton et al.   DEVELOPMENTAL CELL

Distinct Roles for ROCK1 and ROCK2 in the Regulation of Keratinocyte Differentiation

(2009) Frances E. Lock et al.   PLoS One