MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer

CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT/GSK-3β/β-catenin pathway

(2019) Jiaomeng Pan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation

(2019) Ina Katrine Nitschke Pettersen et al.   MITOCHONDRION

Feasibility of Classification of Triple Negative Breast Cancer by Immunohistochemical Surrogate Markers

(2018) Sewha Kim et al.   Clinical Breast Cancer

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis

(2018) Andras Ladanyi et al.   ONCOGENE

MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state

(2018) Vittoria Poli et al.   Nature Communications

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations

(2018) Roddy S. O’Connor et al.   Scientific Reports

Calcium signalling links MYC to NUAK1

(2017) T Monteverde et al.   ONCOGENE

Claudin-Low Breast Cancer; Clinical & Pathological Characteristics

(2017) Kay Dias et al.   PLoS One

CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation

(2017) Heather J. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Turnover and flow of the cell membrane for cell migration

(2017) Masahito Tanaka et al.   Scientific Reports

GZD856, a novel potent PDGFRα/β inhibitor, suppresses the growth and migration of lung cancer cells in vitro and in vivo

(2016) Zhang Zhang et al.   CANCER LETTERS

The transition of smooth muscle cells from a contractile to a migratory, phagocytic phenotype: direct demonstration of phenotypic modulation

(2016) Mairi E. Sandison et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exogenous FABP4 increases breast cancer cell proliferation and activates the expression of fatty acid transport proteins

(2016) Sandra Guaita-Esteruelas et al.   MOLECULAR CARCINOGENESIS

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

(2016) Bernard Pereira et al.   Nature Communications

Carnitine palmitoyl transferase-1A (CPT1A): a new tumor specific target in human breast cancer

(2016) Sabina Pucci et al.   Oncotarget

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

FOXF2 suppresses the FOXC2-mediated epithelial–mesenchymal transition and multidrug resistance of basal-like breast cancer

(2015) Jun Cai et al.   CANCER LETTERS

Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise

(2015) Sarah E. Seiler et al.   Cell Metabolism

Down-Regulation of SLC8A1 as a Putative Apoptosis Evasion Mechanism by Modulation of Calcium Levels in Penile Carcinoma

(2015) Juan J. Muñoz et al.   JOURNAL OF UROLOGY

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

MYC and metabolism on the path to cancer

(2015) Annie L. Hsieh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Interaction of CDCP1 with HER2 Enhances HER2-Driven Tumorigenesis and Promotes Trastuzumab Resistance in Breast Cancer

(2015) Abdullah Alajati et al.   Cell Reports

Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

(2015) Aritro Nath et al.   Scientific Reports

c-Myc Programs Fatty Acid Metabolism and Dictates Acetyl-CoA Abundance and Fate

(2014) Lia R. Edmunds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

(2014) Susanne Walz et al.   NATURE

An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer

(2014) Michael L Gatza et al.   NATURE GENETICS

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility

(2014) Shuai Zhang et al.   Nutrition & Metabolism

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

(2013) H. Zirath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells

(2012) D. S. Spassov et al.   CANCER RESEARCH

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

(2012) Deborah M. Muoio et al.   Cell Metabolism

Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity

(2012) Y. Kim et al.   GENES & DEVELOPMENT

A Regulatory Feedback Loop Between Ca2+/Calmodulin-dependent Protein Kinase Kinase 2 (CaMKK2) and the Androgen Receptor in Prostate Cancer Progression

(2012) Loukia G. Karacosta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A metabolic prosurvival role for PML in breast cancer

(2012) Arkaitz Carracedo et al.   JOURNAL OF CLINICAL INVESTIGATION

Deregulated MYC expression induces dependence upon AMPK-related kinase 5

(2012) Lidan Liu et al.   NATURE

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

(2011) Charles E Massie et al.   EMBO JOURNAL

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Heterogeneity in MYC-induced mammary tumors contributes to escape from oncogene dependence

(2011) J Y Leung et al.   ONCOGENE

CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells

(2010) Daniel E. Frigo et al.   CANCER RESEARCH

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

(2010) E. Rysman et al.   CANCER RESEARCH

MYC Overexpression Induces Prostatic Intraepithelial Neoplasia and Loss of Nkx3.1 in Mouse Luminal Epithelial Cells

(2010) Tsuyoshi Iwata et al.   PLoS One

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Meta-Analysis and Gene Set Enrichment Relative to ER Status Reveal Elevated Activity of MYC and E2F in the “Basal” Breast Cancer Subgroup

(2009) M. Chehani Alles et al.   PLoS One

A Core MYC Gene Expression Signature Is Prominent in Basal-Like Breast Cancer but Only Partially Overlaps the Core Serum Response

(2009) Sanjay Chandriani et al.   PLoS One

Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential

(2009) E. R. Andrechek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of Hepatic Mitochondrial Injury Induced by Fatty Acid Oxidation Inhibitors

(2009) Alison E.M. Vickers   TOXICOLOGIC PATHOLOGY

Immortalization and transformation of human mammary epithelial cells by a tumor-derived Myc mutant

(2008) Clare A. Thibodeaux et al.   BREAST CANCER RESEARCH AND TREATMENT

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

CD36-dependent Regulation of Muscle FoxO1 and PDK4 in the PPARδ/β-mediated Adaptation to Metabolic Stress

(2008) Zaher Nahlé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY