Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau

PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3β

(2017) Wei Qian et al.   JOURNAL OF ALZHEIMERS DISEASE

Metabolic crisis occurs with seizures and periodic discharges after brain trauma

(2016) Paul Vespa et al.   ANNALS OF NEUROLOGY

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

(2015) Sandy R. Shultz et al.   BRAIN

Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model

(2015) Pablo Miguel Casillas-Espinosa et al.   PLoS One

Granulocyte-Macrophage Colony-Stimulating Factor Is Neuroprotective in Experimental Traumatic Brain Injury

(2014) Sandy R. Shultz et al.   JOURNAL OF NEUROTRAUMA

The challenge and promise of anti-epileptic therapy development in animal models

(2014) Michele Simonato et al.   LANCET NEUROLOGY

Can structural or functional changes following traumatic brain injury in the rat predict epileptic outcome?

(2013) Sandy R. Shultz et al.   EPILEPSIA

Evaluating Alzheimer’s Disease Progression Using Rate of Regional Hippocampal Atrophy

(2013) Edit Frankó et al.   PLoS One

DNA Methylation Mediates Persistent Epileptiform Activity In Vitro and In Vivo

(2013) Ziv M. Machnes et al.   PLoS One

Hypometabolism precedes limbic atrophy and spontaneous recurrent seizures in a rat model of TLE

(2012) Bianca Jupp et al.   EPILEPSIA

Identification of new epilepsy treatments: Issues in preclinical methodology

(2012) Aristea S. Galanopoulou et al.   EPILEPSIA

T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures

(2012) E. Tringham et al.   Science Translational Medicine

An experimental rat model of sporadic Alzheimer’s disease and rescue of cognitive impairment with a neurotrophic peptide

(2011) Silvia Bolognin et al.   ACTA NEUROPATHOLOGICA

Amyloid-β associated volume loss occurs only in the presence of phospho-tau

(2011) Rahul S. Desikan et al.   ANNALS OF NEUROLOGY

Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study

(2011) Maria Thom et al.   BRAIN

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

Targeting hyperphosphorylated tau with sodium selenate suppresses seizures in rodent models

(2011) Nigel C. Jones et al.   NEUROBIOLOGY OF DISEASE

The time course of acquired epilepsy: Implications for therapeutic intervention to suppress epileptogenesis

(2011) F. Edward Dudek et al.   NEUROSCIENCE LETTERS

Open-label, phase I dose-escalation study of sodium selenate, a novel activator of PP2A, in patients with castration-resistant prostate cancer

(2010) N M Corcoran et al.   BRITISH JOURNAL OF CANCER

Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer’s disease model

(2010) Niall M. Corcoran et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research

(2010) W. Loscher et al.   PHARMACOLOGICAL REVIEWS

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models

(2010) J. van Eersel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy

(2009) Norbert Zilka et al.   JOURNAL OF NEUROIMMUNOLOGY

Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats

(2008) Kim L. Powell et al.   EPILEPSIA

Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy

(2008) Vassiliki Aroniadou-Anderjaska et al.   EPILEPSY RESEARCH

Folate Deficiency Induces In Vitro and Mouse Brain Region-Specific Downregulation of Leucine Carboxyl Methyltransferase-1 and Protein Phosphatase 2A B  Subunit Expression That Correlate with Enhanced Tau Phosphorylation

(2008) J.-M. Sontag et al.   JOURNAL OF NEUROSCIENCE

Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

(2008) Yanhui Xu et al.   MOLECULAR CELL

PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail)

(2008) Veerle Janssens et al.   TRENDS IN BIOCHEMICAL SCIENCES