Transcriptional and post-transcriptional regulation of β-secretase

Mitochondrial Alterations, Oxidative Stress and Neuroinflammation in Alzheimer's Disease

(2017) M. Verri et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Inflammation and NF-κB in Alzheimer's Disease and Diabetes

(2017) Ivica Granic et al.   JOURNAL OF ALZHEIMERS DISEASE

Increases in β-amyloid protein in the hippocampus caused by diabetic metabolic disorder are blocked by minocycline through inhibition of NF-κB pathway activation

(2014) Zhiyou Cai et al.   Pharmacological Reports

Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation

(2012) Michela Guglielmotto et al.   AGING CELL

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

Mechanisms Involved in BACE Upregulation Associated to Stress

(2012) Eva Martisova et al.   Current Alzheimer Research

Nuclear Factor-κB Regulates βAPP and β- and γ-Secretases Differently at Physiological and Supraphysiological Aβ Concentrations

(2012) Linda Chami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Amyloid 1-42 induces physiological transcriptional regulation of BACE1

(2012) Alessandra Piccini et al.   JOURNAL OF NEUROCHEMISTRY

Aβ42 production in brain capillary endothelial cells after oxygen and glucose deprivation

(2012) Alessandra Bulbarelli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Transcriptional regulation of βsecretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments

(2011) Jin Chu et al.   ANNALS OF NEUROLOGY

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

(2011) Dun-Sheng Yang et al.   Autophagy

Autophagy in neurodegeneration: two sides of the same coin

(2011) Jin-A Lee   BMB Reports

Vascular signaling abnormalities in Alzheimer disease

(2011) P. GRAMMAS et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Tolfenamic Acid Interrupts the De Novo Synthesis of the β-Amyloid Precursor Protein and Lowers Amyloid Beta Via a Transcriptional Pathway

(2011) L. I. Adwan et al.   Current Alzheimer Research

Anatabine lowers Alzheimer's Aβ production in vitro and in vivo

(2011) Daniel Paris et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

NF-κB signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression

(2011) Ruitao Wang et al.   JOURNAL OF NEUROCHEMISTRY

Sphingosylphosphorylcholine Attenuated β–Amyloid Production by Reducing BACE1 Expression and Catalysis in PC12 Cells

(2011) Hyoseok Yi et al.   NEUROCHEMICAL RESEARCH

Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease

(2011) Zhiyou Cai et al.   NEUROMOLECULAR MEDICINE

Microarray Analysis on Human Neuroblastoma Cells Exposed to Aluminum, β1–42-Amyloid or the β1–42-Amyloid Aluminum Complex

(2011) Valentina Gatta et al.   PLoS One

Ubiquitin Regulates GGA3-mediated Degradation of BACE1

(2010) Eugene L. Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

(2010) Michela Guglielmotto et al.   NEUROBIOLOGY OF AGING

Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice

(2010) E. Masliah et al.   NEUROSCIENCE

Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells

(2010) Qing-Yun Li et al.   NEUROSCIENCE LETTERS

Attenuation of oxidative stress, inflammation and apoptosis by minocycline prevents retrovirus-induced neurodegeneration in mice

(2009) Xianghong Kuang et al.   BRAIN RESEARCH

Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease

(2009) S.M. Cardoso et al.   EXPERIMENTAL NEUROLOGY

Mutant Presenilin 1 Increases the Expression and Activity of BACE1

(2009) Luca Giliberto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gga2 Mediates Sequential Ubiquitin-independent and Ubiquitin-dependent Steps in the Trafficking of ARN1 from thetrans-Golgi Network to the Vacuole

(2009) Yi Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promotion of BACE1 mRNA Alternative Splicing Reduces Amyloid β-Peptide Production

(2008) Karen R. Mowrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NFκB-dependent Control ofBACE1Promoter Transactivation by Aβ42

(2008) Virginie Buggia-Prevot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

(2008) Michela Guglielmotto et al.   JOURNAL OF NEUROCHEMISTRY

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

(2008) Mohammad Ali Faghihi et al.   NATURE MEDICINE

JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1

(2008) Elena Tamagno et al.   NEUROBIOLOGY OF AGING

Evidence that γ-secretase mediates oxidative stress-induced β-secretase expression in Alzheimer's disease

(2008) Dong-Gyu Jo et al.   NEUROBIOLOGY OF AGING

Translational Control of BACE1 May Go Awry in Alzheimer's Disease

(2008) Philip C. Wong   NEURON

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON