The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression

Enhancement of BDNF expression and memory by HDAC inhibition requires BET bromodomain reader proteins

(2018) GC Sartor et al.   JOURNAL OF NEUROSCIENCE

Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model

(2018) Karolina J. Janczura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular genetics of eye diseases

(2017) Jonathan L. Haines et al.   HUMAN MOLECULAR GENETICS

Reduced Expression of Foxp1 as a Contributing Factor in Huntington's Disease

(2017) Anto Sam Crosslee Louis Sam Titus et al.   JOURNAL OF NEUROSCIENCE

Neurotrophin signalling: novel insights into mechanisms and pathophysiology

(2016) M. Mitre et al.   CLINICAL SCIENCE

Inhibition of Histone Deacetylase 3 Restores Amyloid-β Oligomer-Induced Plasticity Deficit in Hippocampal CA1 Pyramidal Neurons

(2016) Kumar Krishna et al.   JOURNAL OF ALZHEIMERS DISEASE

Transcriptional Regulation of Brain-derived Neurotrophic Factor Coding Exon IX

(2016) Bindu Nair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Synaptotagmin 10 as Effector of NPAS4-Mediated Protection from Excitotoxic Neurodegeneration

(2016) Anne M.H. Woitecki et al.   JOURNAL OF NEUROSCIENCE

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior

(2016) Alexi Nott et al.   NATURE NEUROSCIENCE

Npas4: Linking Neuronal Activity to Memory

(2016) Xiaochen Sun et al.   TRENDS IN NEUROSCIENCES

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

Effects of Npas4 deficiency on anxiety, depression-like, cognition and sociability behaviour

(2015) Emily J. Jaehne et al.   BEHAVIOURAL BRAIN RESEARCH

Regulation of hippocampal synaptic plasticity by BDNF

(2015) Graciano Leal et al.   BRAIN RESEARCH

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia

(2015) Fong Choy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Featured Article: Transcriptome profiling of expression changes during neuronal death by RNA-Seq

(2014) Dharmendra Sharma et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Histone Deacetylase 3 Is Necessary for Proper Brain Development

(2014) Jordan Norwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HSF1 Protects Neurons through a Novel Trimerization- and HSP-Independent Mechanism

(2014) P. Verma et al.   JOURNAL OF NEUROSCIENCE

Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury

(2014) Heather M Schmitt et al.   Molecular Neurodegeneration

HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation

(2014) Haiqun Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HDAC3 Is a Negative Regulator of Cocaine-Context-Associated Memory Formation

(2013) G. A. Rogge et al.   JOURNAL OF NEUROSCIENCE

Disassociation of Histone Deacetylase-3 from Normal Huntingtin Underlies Mutant Huntingtin Neurotoxicity

(2013) F. H. Bardai et al.   JOURNAL OF NEUROSCIENCE

Role of BDNF in Central Motor Structures and Motor Diseases

(2013) Yan-Yan He et al.   MOLECULAR NEUROBIOLOGY

The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition

(2013) Brenda L. Bloodgood et al.   NATURE

Activity-dependent neuronal signalling and autism spectrum disorder

(2013) Daniel H. Ebert et al.   NATURE

Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction

(2013) Andrii Rudenko et al.   NEURON

BDNF and memory processing

(2013) Pedro Bekinschtein et al.   NEUROPHARMACOLOGY

HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner

(2013) M. Malvaez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-DependentNPAS4Expression and the Regulation of Gene Programs Underlying Plasticity in the Central Nervous System

(2013) José Fernando Maya-Vetencourt   NEURAL PLASTICITY

A 1 Mb de novo deletion within 11q13.1q13.2 in a boy with mild intellectual disability and minor dysmorphic features

(2012) Karijn Floor et al.   European Journal of Medical Genetics

Histone Deacetylase-1 (HDAC1) Is a Molecular Switch between Neuronal Survival and Death

(2012) Farah H. Bardai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease

(2012) Haiqun Jia et al.   NEUROBIOLOGY OF DISEASE

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

(2011) S. E. Mullican et al.   GENES & DEVELOPMENT

HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

(2011) S. C. McQuown et al.   JOURNAL OF NEUROSCIENCE

Identification of cis-Elements and Transcription Factors Regulating Neuronal Activity-Dependent Transcription of Human BDNF Gene

(2011) P. Pruunsild et al.   JOURNAL OF NEUROSCIENCE

Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3 

(2011) F. H. Bardai et al.   JOURNAL OF NEUROSCIENCE

Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II

(2011) Ramendra N Saha et al.   NATURE NEUROSCIENCE

HDAC3 and the molecular brake pad hypothesis

(2011) Susan C. McQuown et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation

(2011) K. Ramamoorthi et al.   SCIENCE

Histone deacetylases as targets for the treatment of human neurodegenerative diseases

(2010) S.R. D'Mello   DRUG NEWS & PERSPECTIVES

Neuroprotection by Histone Deacetylase-7 (HDAC7) Occurs by Inhibition of c-junExpression through a Deacetylase-independent Mechanism

(2010) Chi Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interaction between Nuclear Receptor Corepressor and Histone Deacetylase 3 Regulates Both Positive and Negative Thyroid Hormone Actionin Vivo

(2010) Seo-Hee You et al.   MOLECULAR ENDOCRINOLOGY

Putting the ‘HAT’ back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions

(2009) Sama F Sleiman et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Focal Nature of Neurological Disorders Necessitates Isotype-Selective Histone Deacetylase (HDAC) Inhibitors

(2009) Elizabeth A. Thomas   MOLECULAR NEUROBIOLOGY

ChIP-seq accurately predicts tissue-specific activity of enhancers

(2009) Axel Visel et al.   NATURE

Insights from genomic profiling of transcription factors

(2009) Peggy J. Farnham   NATURE REVIEWS GENETICS

Brain-derived neurotrophic factor in neurodegenerative diseases

(2009) Chiara Zuccato et al.   Nature Reviews Neurology

Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity

(2009) Sheng-Jia Zhang et al.   PLoS Genetics

Biological and Potential Therapeutic Roles of Sirtuin Deacetylases

(2008) D. M. Taylor et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

HDAC4 inhibits cell-cycle progression and protects neurons from cell death

(2008) Nazanin Majdzadeh et al.   Developmental Neurobiology

Functional Characterization of Basic Helix-Loop-Helix-PAS Type Transcription Factor NXFin Vivo

(2008) Norihisa Ooe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-dependent regulation of inhibitory synapse development by Npas4

(2008) Yingxi Lin et al.   NATURE

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HDAC Inhibitors Correct Frataxin Deficiency in a Friedreich Ataxia Mouse Model

(2008) Myriam Rai et al.   PLoS One

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

(2008) E. A. Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA