Putting the ‘HAT’ back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions

A preliminary report on spinal muscular atrophy lymphoblastoid cell lines: Are they an appropriate tool for drug screening?

(2008) Didem Dayangaç-Erden et al.   ADVANCES IN THERAPY

Histone deacetylase inhibitors: Mechanisms of cell death and promise in combination cancer therapy

(2008) Jennifer S. Carew et al.   CANCER LETTERS

A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy

(2008) Tetsuro Ago et al.   CELL

Histone Deacetylase Inhibitors: Therapeutic Agents and Research Tools for Deciphering Motor Neuron Diseases

(2008) A. Echaniz-Laguna et al.   CURRENT MEDICINAL CHEMISTRY

Histone Deacetylase Inhibitors in Cancer Therapy: New Compounds and Clinical Update of Benzamide-Type Agents

(2008) Oscar Moradei et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Histone deacetylase inhibitors: possible implications for neurodegenerative disorders

(2008) Eric Hahnen et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice

(2008) Anne Granger et al.   FASEB JOURNAL

BM88/Cend1 is involved in histone deacetylase inhibition-mediated growth arrest and differentiation of neuroblastoma cells

(2008) Panagiotis K. Politis et al.   FEBS LETTERS

Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition

(2008) Jan Hauke et al.   HUMAN MOLECULAR GENETICS

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

(2008) Judit Pallos et al.   HUMAN MOLECULAR GENETICS

Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons

(2008) Xuefei Wu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

DNA Damage and Repair

(2008) Lee J. Martin   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Synergistic Neuroprotective Effects of Lithium and Valproic Acid or Other Histone Deacetylase Inhibitors in Neurons: Roles of Glycogen Synthase Kinase-3 Inhibition

(2008) Y. Leng et al.   JOURNAL OF NEUROSCIENCE

Histone Deacetylase Inhibitors Decrease Cocaine But Not Sucrose Self-Administration in Rats

(2008) P. Romieu et al.   JOURNAL OF NEUROSCIENCE

Pulse Inhibition of Histone Deacetylases Induces Complete Resistance to Oxidative Death in Cortical Neurons without Toxicity and Reveals a Role for Cytoplasmic p21waf1/cip1 in Cell Cycle-Independent Neuroprotection

(2008) B. Langley et al.   JOURNAL OF NEUROSCIENCE

Brain Chromatin Remodeling: A Novel Mechanism of Alcoholism

(2008) S. C. Pandey et al.   JOURNAL OF NEUROSCIENCE

S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

(2008) Alexi Nott et al.   NATURE

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

(2008) Aleksey G. Kazantsev et al.   NATURE REVIEWS DRUG DISCOVERY

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON

HDAC Inhibitors Correct Frataxin Deficiency in a Friedreich Ataxia Mouse Model

(2008) Myriam Rai et al.   PLoS One

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

(2008) E. A. Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced baseline acetylated histone 3 levels, and a blunted response to HDAC inhibition in lymphocyte cultures from schizophrenia subjects

(2008) David P. Gavin et al.   SCHIZOPHRENIA RESEARCH

SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome

(2008) Rea Biacsi et al.   PLoS Genetics

Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection

(2007) Rajiv P. Sharma et al.   SCHIZOPHRENIA RESEARCH