Analysis of chemometric models applied to Raman spectroscopy for monitoring key metabolites of cell culture

Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing

(2016) Karen A. Esmonde-White et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

(2016) Thomas E. Matthews et al.   BIOTECHNOLOGY AND BIOENGINEERING

In-line and real-time prediction of recombinant antibody titer by in situ Raman spectroscopy

(2015) Silvère André et al.   ANALYTICA CHIMICA ACTA

Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture

(2015) Brandon N. Berry et al.   BIOTECHNOLOGY PROGRESS

Generic Raman-based calibration models enabling real-time monitoring of cell culture bioreactors

(2015) Hamidreza Mehdizadeh et al.   BIOTECHNOLOGY PROGRESS

Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

(2015) Julián López-Meza et al.   CYTOTECHNOLOGY

Inhibitory Effect of Excessive Glucose on Its Biochemical Pathway and the Growth of Chinese Hamster Ovary (CHO) Cells

(2015) Tsung-Yih Lee et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Raman spectroscopy of complex defined media: biopharmaceutical applications

(2015) Gajendra P. Singh et al.   JOURNAL OF RAMAN SPECTROSCOPY

Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis

(2014) Brandon Berry et al.   BIOTECHNOLOGY PROGRESS

Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller

(2014) Stephen Craven et al.   JOURNAL OF PROCESS CONTROL

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

Bioreactor monitoring with spectroscopy and chemometrics: a review

(2012) N. D. Lourenço et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors

(2012) Jessica Whelan et al.   BIOTECHNOLOGY PROGRESS

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

(2012) Francesca Zagari et al.   New Biotechnology

In situ sensor techniques in modern bioprocess monitoring

(2011) Sascha Beutel et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Comparative metabolic analysis of lactate for CHO cells in glucose and galactose

(2011) Camila A. Wilkens et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry

(2011) Woo Suk Ahn et al.   METABOLIC ENGINEERING

Process analytical technology (PAT) for biopharmaceutical products

(2010) A. S. Rathore et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Rapid characterization and quality control of complex cell culture media solutions using raman spectroscopy and chemometrics

(2010) Boyan Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY