Comparison of Modeling Methods for DoE‐Based Holistic Upstream Process Characterization

Model-assisted Design of Experiments as a concept for knowledge-based bioprocess development

(2019) Johannes Möller et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

The impact of technical failures during cultivation of an inclusion body process

(2019) Alexander Pekarsky et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

The shortcomings of accurate rate estimations in cultivation processes and a solution for precise and robust process modeling

(2019) B. Bayer et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Soft sensor based on 2D‐fluorescence and process data enabling real‐time estimation of biomass in Escherichia coli cultivations

(2019) Benjamin Bayer et al.   ENGINEERING IN LIFE SCIENCES

Quality by design (QbD) approaches in current pharmaceutical set-up

(2018) Vijay Mishra et al.   Expert Opinion on Drug Delivery

Hybrid modeling as a QbD/PAT tool in process development: an industrial E. coli case study

(2016) Moritz von Stosch et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Toward intensifying design of experiments in upstream bioprocess development: An industrialEscherichia colifeasibility study

(2016) Moritz von Stosch et al.   BIOTECHNOLOGY PROGRESS

Intensified design of experiments for upstream bioreactors

(2016) Moritz von Stosch et al.   ENGINEERING IN LIFE SCIENCES

The potential of random forest and neural networks for biomass and recombinant protein modeling inEscherichia colifed-batch fermentations

(2015) Michael Melcher et al.   Biotechnology Journal

Progress toward forecasting product quality and quantity of mammalian cell culture processes by performance-based modeling

(2015) Timo Schmidberger et al.   BIOTECHNOLOGY PROGRESS

An efficient method for the numerical integration of measured variable dependent ordinary differential equations

(2015) C. Rodrigues de Azevedo et al.   ENGINEERING APPLICATIONS OF ARTIFICIAL INTELLIGENCE

Fluorescence Spectroscopy and Chemometric Modeling for Bioprocess Monitoring

(2015) Saskia Faassen et al.   SENSORS

The potential of random forest and neural networks for biomass and recombinant protein modeling inEscherichia colifed-batch fermentations

(2015) Michael Melcher et al.   Biotechnology Journal

Designed Amino Acid Feed in Improvement of Production and Quality Targets of a Therapeutic Monoclonal Antibody

(2015) Fatemeh Torkashvand et al.   PLoS One

Fluorescence-based soft sensor for at situ monitoring of chinese hamster ovary cell cultures

(2014) Kaveh Ohadi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Development of a soft-sensor based on multi-wavelength fluorescence spectroscopy and a dynamic metabolic model for monitoring mammalian cell cultures

(2014) Kaveh Ohadi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Hybrid modeling for quality by design and PAT-benefits and challenges of applications in biopharmaceutical industry

(2014) Moritz von Stosch et al.   Biotechnology Journal

Online prediction of product titer and solubility of recombinant proteins in Escherichia colifed-batch cultivations

(2014) Markus Luchner et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Chemometrics application in biotech processes: assessing comparability across processes and scales

(2014) Anurag S. Rathore et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

QbD/PAT for bioprocessing: moving from theory to implementation

(2014) Anurag S Rathore   Current Opinion in Chemical Engineering

Design of experiments applications in bioprocessing: Concepts and approach

(2013) Vijesh Kumar et al.   BIOTECHNOLOGY PROGRESS

Hybrid semi-parametric modeling in process systems engineering: Past, present and future

(2013) Moritz von Stosch et al.   COMPUTERS & CHEMICAL ENGINEERING

Evaluation of three industrial Escherichia coli strains in fed-batch cultivations during high-level SOD protein production

(2013) Karoline Marisch et al.   Microbial Cell Factories

Real-time estimation of biomass and specific growth rate in physiologically variable recombinant fed-batch processes

(2012) Patrick Wechselberger et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Quality by Design and Process Analytical Technology for Sterile Products—Where Are We Now?

(2010) Bryan S. Riley et al.   AAPS PHARMSCITECH

An Example of Utilizing Mechanistic and Empirical Modeling in Quality by Design

(2010) Daniel M. Hallow et al.   Journal of Pharmaceutical Innovation

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY

Bioprocess optimization using design-of-experiments methodology

(2008) Carl-Fredrik Mandenius et al.   BIOTECHNOLOGY PROGRESS