Model-assisted Design of Experiments as a concept for knowledge-based bioprocess development
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Model-assisted Design of Experiments as a concept for knowledge-based bioprocess development
Authors
Keywords
Chinese hamster ovary, Feeding profile, Response surface, Modeling
Journal
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2019-02-26
DOI
10.1007/s00449-019-02089-7
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mechanisms driving the lactate switch in Chinese hamster ovary cells
- (2018) Fiona Hartley et al. BIOTECHNOLOGY AND BIOENGINEERING
- Model-Based Identification of Cell-Cycle Dependent Metabolism and Putative Autocrine Effects in Antibody Producing CHO Cell Culture
- (2018) Johannes Möller et al. BIOTECHNOLOGY AND BIOENGINEERING
- Process and metabolic engineering perspectives of lactate production in mammalian cell cultures
- (2018) Mauro Torres et al. Current Opinion in Chemical Engineering
- Model-based tools for optimal experiments in bioprocess engineering
- (2018) Vinzenz Abt et al. Current Opinion in Chemical Engineering
- Workflow to set up substantial target-oriented mechanistic process models in bioprocess engineering
- (2017) Paul Kroll et al. PROCESS BIOCHEMISTRY
- Workflow for Target-Oriented Parametrization of an Enhanced Mechanistic Cell Culture Model
- (2017) Sophia Ulonska et al. Biotechnology Journal
- Regulation of cell growth and apoptosis through lactate dehydrogenase C over-expression in Chinese hamster ovary cells
- (2016) Tuo Fu et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Reduction of ammonia and lactate through the coupling of glutamine synthetase selection and downregulation of lactate dehydrogenase-A in CHO cells
- (2016) Soo Min Noh et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Hybrid modeling as a QbD/PAT tool in process development: an industrial E. coli case study
- (2016) Moritz von Stosch et al. BIOPROCESS AND BIOSYSTEMS ENGINEERING
- Understanding of alteredN-glycosylation-related gene expression in recombinant Chinese hamster ovary cells subjected to elevated ammonium concentration by digital mRNA counting
- (2015) Tae Kwang Ha et al. BIOTECHNOLOGY AND BIOENGINEERING
- Glycoprofiling effects of media additives on IgG produced by CHO cells in fed-batch bioreactors
- (2015) Helene Faustrup Kildegaard et al. BIOTECHNOLOGY AND BIOENGINEERING
- Development and manufacturability assessment of chemically-defined medium for the production of protein therapeutics in CHO cells
- (2015) Wai Lam W. Ling et al. BIOTECHNOLOGY PROGRESS
- Model-based strategy for cell culture seed train layout verified at lab scale
- (2015) Simon Kern et al. CYTOTECHNOLOGY
- Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells
- (2015) Julián López-Meza et al. CYTOTECHNOLOGY
- Growth kinetics and validation of near-physiologically synchronized HEK293S Cultures
- (2015) Alan Eduardo Castillo Salvador et al. ENGINEERING IN LIFE SCIENCES
- Quantification of cell lysis during CHO bioprocesses: Impact on cell count, growth kinetics and productivity
- (2015) Tobias Klein et al. JOURNAL OF BIOTECHNOLOGY
- The DNA methylation landscape of Chinese hamster ovary (CHO) DP-12 cells
- (2015) Anna Wippermann et al. JOURNAL OF BIOTECHNOLOGY
- Designed Amino Acid Feed in Improvement of Production and Quality Targets of a Therapeutic Monoclonal Antibody
- (2015) Fatemeh Torkashvand et al. PLoS One
- Modulation of mAb quality attributes using microliter scale fed-batch cultures
- (2014) Yolande Rouiller et al. BIOTECHNOLOGY PROGRESS
- Experimental design and multiple response optimization. Using the desirability function in analytical methods development
- (2014) Luciana Vera Candioti et al. TALANTA
- Design of experiments applications in bioprocessing: Concepts and approach
- (2013) Vijesh Kumar et al. BIOTECHNOLOGY PROGRESS
- Development and design of bio-pharmaceutical processes
- (2013) Cleo Kontoravdi et al. Current Opinion in Chemical Engineering
- Effects of high passage cultivation on CHO cells: a global analysis
- (2012) T. F. Beckmann et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Macroscopic modelling of overflow metabolism and model based optimization of hybridoma cell fed-batch cultures
- (2012) Zakaria Amribt et al. BIOCHEMICAL ENGINEERING JOURNAL
- Automated dynamic fed-batch process and media optimization for high productivity cell culture process development
- (2012) Franklin Lu et al. BIOTECHNOLOGY AND BIOENGINEERING
- Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture
- (2012) Suresh Selvarasu et al. BIOTECHNOLOGY AND BIOENGINEERING
- How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?
- (2012) Manuel J. T. Carrondo et al. Biotechnology Journal
- Optimal experiment design for dynamic bioprocesses: A multi-objective approach
- (2012) D. Telen et al. CHEMICAL ENGINEERING SCIENCE
- Rational development of a serum-free medium and fed-batch process for a GS-CHO cell line expressing recombinant antibody
- (2012) Huifeng Zhang et al. CYTOTECHNOLOGY
- Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance
- (2011) Jincai Li et al. BIOTECHNOLOGY AND BIOENGINEERING
- High-End pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed-batch cultures
- (2011) Matthew Gagnon et al. BIOTECHNOLOGY AND BIOENGINEERING
- Process analytical technology (PAT) for biopharmaceuticals
- (2011) Jarka Glassey et al. Biotechnology Journal
- Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases
- (2011) Meixia Zhou et al. JOURNAL OF BIOTECHNOLOGY
- Novel micro-bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed-batch CHO cultures
- (2010) Ashraf Amanullah et al. BIOTECHNOLOGY AND BIOENGINEERING
- Dynamic model of CHO cell metabolism
- (2010) Ryan P. Nolan et al. METABOLIC ENGINEERING
- Development of serum-free medium supplemented with hydrolysates for the production of therapeutic antibodies in CHO cell cultures using design of experiments
- (2009) Sung Hyun Kim et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- A predictive high-throughput scale-down model of monoclonal antibody production in CHO cells
- (2009) Rachel Legmann et al. BIOTECHNOLOGY AND BIOENGINEERING
- Quality-by-Design for biotechnology-related pharmaceuticals
- (2009) Carl-Fredrik Mandenius et al. Biotechnology Journal
- Use of response surface methodology in a fed-batch process for optimization of tricarboxylic acid cycle intermediates to achieve high levels of canthaxanthin from Dietzia natronolimnaea HS-1
- (2009) Mohammad Reza Nasri Nasrabadi et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Bioprocess optimization using design-of-experiments methodology
- (2008) Carl-Fredrik Mandenius et al. BIOTECHNOLOGY PROGRESS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now