The cGMP system: components and function

Endothelial C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodeling

(2019) Kristen J. Bubb et al.   CIRCULATION

Evaluation of the efficacy, safety and tolerability of orally administered BI 409306, a novel phosphodiesterase type 9 inhibitor, in two randomised controlled phase II studies in patients with prodromal and mild Alzheimer’s disease

(2019) Lutz Frölich et al.   Alzheimers Research & Therapy

Determination of basal phosphodiesterase activity in mouse rod photoreceptors with cGMP clamp

(2019) Teemu T. Turunen et al.   Scientific Reports

The pseudokinase domains of guanylyl cyclase–A and –B allosterically increase the affinity of their catalytic domains for substrate

(2019) Aaron B. Edmund et al.   Science Signaling

Self-regulation and theforaginggene (PRKG1) in humans

(2019) Andriy A. Struk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD)

(2019) Pacific Huynh et al.   CLINICAL SCIENCE

Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention

(2019) Thorsten Kessler et al.   CARDIOVASCULAR RESEARCH

CRRL269

(2019) Yang Chen et al.   CIRCULATION RESEARCH

Active PKG II inhibited the growth and migration of ovarian cancer cells through blocking Raf/ MEK and PI3K/Akt signaling pathways

(2019) Yan Wu et al.   BIOSCIENCE REPORTS

C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia

(2019) Ravi Savarirayan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation

(2019) Majida El Bakkouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sildenafil Reduces Neointimal Hyperplasia after Angioplasty and Inhibits Platelet Aggregation via Activation of cGMP-dependent Protein Kinase

(2019) Han-Mo Yang et al.   Scientific Reports

High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites

(2019) Maria Penzo et al.   Scientific Reports

Protein Kinase G Is Involved in Acute but Not in Long-Term Regulation of Renin Secretion

(2019) Andrea Schramm et al.   Frontiers in Pharmacology

Signaling Cascades Governing Entry into and Exit from Host Cells by Toxoplasma gondii

(2019) Hugo Bisio et al.   Annual Review of Microbiology

Structural insights into the mechanism of human soluble guanylate cyclase

(2019) Yunlu Kang et al.   NATURE

Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy

(2019) Benjamin G Horst et al.   eLife

CRRL269: a novel designer and renal-enhancing pGC-A peptide activator

(2018) Yang Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators

(2018) Alexandru-Emil Matei et al.   ANNALS OF THE RHEUMATIC DISEASES

A concise discussion of the regulatory role of cGMP kinase I in cardiac physiology and pathology

(2018) Franz Hofmann   BASIC RESEARCH IN CARDIOLOGY

From molecules to patients: exploring the therapeutic role of soluble guanylate cyclase stimulators

(2018) Peter Sandner   BIOLOGICAL CHEMISTRY

Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase

(2018) Sandra Frankenreiter et al.   CARDIOVASCULAR RESEARCH

Molecular Analysis of Sensory Axon Branching Unraveled a cGMP-Dependent Signaling Cascade

(2018) Alexandre Dumoulin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets

(2018) Stephanie Makhoul et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Physiological activation and deactivation of soluble guanylate cyclase

(2018) Benjamin G. Horst et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Genetic alterations in the NO-cGMP pathway and cardiovascular risk

(2018) Jana Wobst et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Oxidation of cysteine 117 stimulates constitutive activation of the type Iα cGMP-dependent protein kinase

(2018) Jessica L Sheehe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Guanylate Cyclase C—cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia

(2018) Jeffrey A. Rappaport et al.   Frontiers in Oncology

Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery

(2018) Michael A. Hollas et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis

(2018) Lai Wen et al.   Nature Communications

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells

(2017) Motohiro Nishida et al.   FREE RADICAL BIOLOGY AND MEDICINE

The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43

(2017) Hema Kalyanaraman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

(2017) Hadi Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus

(2017) R Polimanti et al.   MOLECULAR PSYCHIATRY

Anti-fibrotic effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence

(2017) Peter Sandner et al.   RESPIRATORY MEDICINE

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

(2017) David A. Baker et al.   Nature Communications

Cyclic nucleotide signalling in malaria parasites

(2017) David A. Baker et al.   Open Biology

Inhibition of the TGFβ signalling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis

(2017) Elisabeth Schinner et al.   FEBS Open Bio

cGMP Binding Domain D Mediates a Unique Activation Mechanism in Plasmodium falciparum PKG

(2017) Eugen Franz et al.   ACS Infectious Diseases

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling

(2017) Connor A. Emdin et al.   CIRCULATION

Physiological Functions of NO-Sensitive Guanylyl Cyclase Isoforms

(2016) Doris Koesling et al.   CURRENT MEDICINAL CHEMISTRY

Feeding-Related Traits Are Affected by Dosage of the foraging Gene in Drosophila melanogaster

(2016) Aaron M. Allen et al.   GENETICS

Iron deficiency anemia in cyclic GMP kinase knockout mice

(2016) E. Angermeier et al.   HAEMATOLOGICA

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Molecular Physiology of Membrane Guanylyl Cyclase Receptors

(2016) Michaela Kuhn   PHYSIOLOGICAL REVIEWS

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels

(2016) K. Khavandi et al.   Science Signaling

Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease

(2016) Tao Su et al.   Scientific Reports

Feeding-Related Traits Are Affected by Dosage of the foraging Gene in Drosophila melanogaster

(2016) Aaron M. Allen et al.   GENETICS

Iron deficiency anemia in cyclic GMP kinase knockout mice

(2016) E. Angermeier et al.   HAEMATOLOGICA

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels

(2016) K. Khavandi et al.   Science Signaling

Cyclic GMP in Vascular RelaxationSignificance

(2015) Christian Krawutschke et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The cGMP/PKG pathway as a common mediator of cardioprotection: translatability and mechanism

(2015) Javier Inserte et al.   BRITISH JOURNAL OF PHARMACOLOGY

Renal effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence

(2015) Johannes-Peter Stasch et al.   CURRENT OPINION IN PHARMACOLOGY

The soluble guanylate cyclase stimulator riociguat and the soluble guanylate cyclase activator cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats

(2015) Yvonne Reinke et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Carperitide Is Associated With Increased In-Hospital Mortality in Acute Heart Failure: A Propensity Score–Matched Analysis

(2015) Yuya Matsue et al.   JOURNAL OF CARDIAC FAILURE

Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors

(2015) Seonil Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

(2015) Mahmood M. Alam et al.   Nature Communications

The Emperor's New Clothes: PDE5 and the Heart

(2015) Chantal V. Degen et al.   PLoS One

Transgenic Mice for Real-Time Visualization of cGMP in Intact Adult Cardiomyocytes

(2014) Konrad R. Götz et al.   CIRCULATION RESEARCH

Cardiomyocyte-Specific Transforming Growth Factor β Suppression Blocks Neutrophil Infiltration, Augments Multiple Cytoprotective Cascades, and Reduces Early Mortality After Myocardial Infarction

(2014) Peter P. Rainer et al.   CIRCULATION RESEARCH

Cyclic GMP Kinase II (cGKII) Inhibits NHE3 by Altering Its Trafficking and Phosphorylating NHE3 at Three Required Sites

(2014) Tiane Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial C-type natriuretic peptide maintains vascular homeostasis

(2014) Amie J. Moyes et al.   JOURNAL OF CLINICAL INVESTIGATION

cGMP-dependent protein kinase type II knockout mice exhibit working memory impairments, decreased repetitive behavior, and increased anxiety-like traits

(2014) Charlotte M. Wincott et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

(2014) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

NO regulates the strength of synaptic inputs onto hippocampal CA1 neurons via NO-GC1/cGMP signalling

(2014) A. Neitz et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Riociguat Reduces Infarct Size and Post-Infarct Heart Failure in Mouse Hearts: Insights from MRI/PET Imaging

(2014) Carmen Methner et al.   PLoS One

Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis

(2014) E. Patrucco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond

(2014) Robert Lukowski et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections

(2013) Dong-chuan Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Atrial Natriuretic Peptide–Mediated Inhibition of Microcirculatory Endothelial Ca 2+ and Permeability Response to Histamine Involves cGMP-Dependent Protein Kinase I and TRPC6 Channels

(2013) Wen Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thrombocytosis as a Response to High Interleukin-6 Levels in cGMP-Dependent Protein Kinase I Mutant Mice

(2013) Lin Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size

(2013) Justin S. Bice et al.   CARDIOVASCULAR RESEARCH

Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium

(2013) R Wang et al.   CELL DEATH AND DIFFERENTIATION

Postsynaptic NO/cGMP Increases NMDA Receptor Currents via Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in the Hippocampus

(2013) Angela Neitz et al.   CEREBRAL CORTEX

Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction in Patients With Preserved Ejection Fraction

(2013) Mads J. Andersen et al.   CIRCULATION

Transgenic Mice for cGMP Imaging

(2013) Martin Thunemann et al.   CIRCULATION RESEARCH

Linaclotide: a novel compound for the treatment of irritable bowel syndrome with constipation

(2013) Robin D Rothstein et al.   EXPERT OPINION ON PHARMACOTHERAPY

Cell-Specific Deletion of Nitric Oxide–Sensitive Guanylyl Cyclase Reveals a Dual Pathway for Nitrergic Neuromuscular Transmission in the Murine Fundus

(2013) Dieter Groneberg et al.   GASTROENTEROLOGY

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction

(2013) Margaret M. Redfield et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Gene replacement therapy for retinal CNG channelopathies

(2013) Christian Schön et al.   MOLECULAR GENETICS AND GENOMICS

Dysfunctional nitric oxide signalling increases risk of myocardial infarction

(2013) Jeanette Erdmann et al.   NATURE

Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Riociguat for the Treatment of Pulmonary Arterial Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protein kinases of Toxoplasma gondii: functions and drug targets

(2013) Feng Wei et al.   PARASITOLOGY RESEARCH

Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa

(2012) Rui Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cyclic GMP-Dependent Signaling in Cardiac Myocytes

(2012) Eiki Takimoto   CIRCULATION JOURNAL

Neuronal cGMP kinase I is essential for stimulation of duodenal bicarbonate secretion by luminal acid

(2012) Anurag Kumar Singh et al.   FASEB JOURNAL

cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function

(2012) Mirko Jaumann et al.   NATURE MEDICINE

Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension

(2012) Oleksandra Prysyazhna et al.   NATURE MEDICINE

The Soluble Guanylyl Cyclase Activator Bay 58-2667 Selectively Limits Cardiomyocyte Hypertrophy

(2012) Jennifer C. Irvine et al.   PLoS One

Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity

(2012) Ceng Luo et al.   PLOS BIOLOGY

sGCα1 mediates the negative inotropic effects of NO in cardiac myocytes independent of changes in calcium handling

(2011) Sharon M. Cawley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Guanylyl cyclase structure, function and regulation

(2011) Lincoln R. Potter   CELLULAR SIGNALLING

Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus

(2011) Angela Neitz et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

cGMP Inhibits TGF-β Signaling by Sequestering Smad3 with Cytosolic β2-Tubulin in Pulmonary Artery Smooth Muscle Cells

(2011) Kaizheng Gong et al.   MOLECULAR ENDOCRINOLOGY

Mechanisms of disease: pulmonary arterial hypertension

(2011) Ralph T. Schermuly et al.   Nature Reviews Cardiology

Two Randomized Trials of Linaclotide for Chronic Constipation

(2011) Anthony J. Lembo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Nesiritide in Patients with Acute Decompensated Heart Failure

(2011) C.M. O'Connor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication

(2011) Brent W. Osborne et al.   STRUCTURE

Phosphodiesterase (PDE) inhibitors in the treatment of lower urinary tract dysfunction

(2010) Stefan Ückert et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias

(2010) Akihiro Yasoda et al.   ENDOCRINE JOURNAL

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

(2010) Alexander P. Bryant et al.   LIFE SCIENCES

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes

(2010) R. Lukowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGMP-dependent protein kinases as potential targets for colon cancer prevention and treatment

(2009) Darren D Browning et al.   Future Medicinal Chemistry

cGMP-Dependent Protein Kinase I Is Crucial for Angiogenesis and Postnatal Vasculogenesis

(2009) Alexandra Aicher et al.   PLoS One

C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons

(2009) H. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing

(2009) Achim Schmidtko et al.   TRENDS IN NEUROSCIENCES

Genetic Basis of Thoracic Aortic Aneurysms and Dissections: Focus on Smooth Muscle Cell Contractile Dysfunction

(2008) Dianna M. Milewicz et al.   Annual Review of Genomics and Human Genetics

Role of Smooth Muscle cGMP/cGKI Signaling in Murine Vascular Restenosis

(2008) Robert Lukowski et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Cyclic GMP/Protein Kinase G Phosphorylation of Smad3 Blocks Transforming Growth Factor-β–Induced Nuclear Smad Translocation

(2008) Iain L.O. Buxton et al.   CIRCULATION RESEARCH