A concise discussion of the regulatory role of cGMP kinase I in cardiac physiology and pathology

Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators

(2018) Alexandru-Emil Matei et al.   ANNALS OF THE RHEUMATIC DISEASES

Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase

(2018) Sandra Frankenreiter et al.   CARDIOVASCULAR RESEARCH

Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED EF (SOCRATES-PRESERVED) study

(2017) Burkert Pieske et al.   EUROPEAN HEART JOURNAL

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

(2017) Hadi Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-fibrotic effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence

(2017) Peter Sandner et al.   RESPIRATORY MEDICINE

Review: Frontiers of Antifibrotic Therapy in Systemic Sclerosis

(2017) Jörg H. W. Distler et al.   Arthritis & Rheumatology

Inhibition of the TGFβ signalling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis

(2017) Elisabeth Schinner et al.   FEBS Open Bio

Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice

(2017) Mark C. Blaser et al.   CIRCULATION RESEARCH

The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge

(2016) Gerd Heusch et al.   EUROPEAN HEART JOURNAL

Hydrogen sulfide mediates the cardioprotective effects of gene therapy with PKG-Iα

(2015) Anindita Das et al.   BASIC RESEARCH IN CARDIOLOGY

Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway

(2015) Sofia-Iris Bibli et al.   CARDIOVASCULAR RESEARCH

Molecular Basis of Cardioprotection: Signal Transduction in Ischemic Pre-, Post-, and Remote Conditioning

(2015) G. Heusch   CIRCULATION RESEARCH

A Molecular Screen Identifies Cardiac Myosin Binding Protein-C as a Protein Kinase G I Alpha Substrate

(2015) Robrecht Thoonen et al.   Circulation-Heart Failure

A background Ca2+entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling

(2015) Juan E. Camacho Londoño et al.   EUROPEAN HEART JOURNAL

The soluble guanylate cyclase stimulator riociguat and the soluble guanylate cyclase activator cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats

(2015) Yvonne Reinke et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction

(2015) Mihai Gheorghiade et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prevention of PKG1α oxidation augments cardioprotection in the stressed heart

(2015) Taishi Nakamura et al.   JOURNAL OF CLINICAL INVESTIGATION

GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia

(2015) Shera Lilyanna et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

(2015) Dong I. Lee et al.   NATURE

Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling

(2014) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Hyperactive Adverse Mechanical Stress Responses in Dystrophic Heart Are Coupled to Transient Receptor Potential Canonical 6 and Blocked by cGMP–Protein Kinase G Modulation

(2014) Kinya Seo et al.   CIRCULATION RESEARCH

Cardiomyocyte-Specific Transforming Growth Factor β Suppression Blocks Neutrophil Infiltration, Augments Multiple Cytoprotective Cascades, and Reduces Early Mortality After Myocardial Infarction

(2014) Peter P. Rainer et al.   CIRCULATION RESEARCH

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Murine cardiac growth, TRPC channels, and cGMP kinase I

(2014) Katrin Domes et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis

(2014) E. Patrucco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust, and beyond

(2014) Robert Lukowski et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G

(2013) Carmen Methner et al.   BASIC RESEARCH IN CARDIOLOGY

The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone

(2013) Florian Loga et al.   CARDIOVASCULAR RESEARCH

PKG Primes the Proteasome

(2013) Thomas G. Gillette et al.   CIRCULATION

Protein Kinase G Positively Regulates Proteasome-Mediated Degradation of Misfolded Proteins

(2013) Mark J. Ranek et al.   CIRCULATION

Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction in Patients With Preserved Ejection Fraction

(2013) Mads J. Andersen et al.   CIRCULATION

Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction

(2013) Margaret M. Redfield et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mutation of the Protein Kinase I Alpha Leucine Zipper Domain Produces Hypertension and Progressive Left Ventricular Hypertrophy: A Novel Mouse Model of Age-Dependent Hypertensive Heart Disease

(2013) Robert M. Blanton et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Protein Kinase G Iα Inhibits Pressure Overload–Induced Cardiac Remodeling and Is Required for the Cardioprotective Effect of Sildenafil In Vivo

(2013) Robert M. Blanton et al.   Journal of the American Heart Association

Nitric Oxide Synthases in Heart Failure

(2012) Ricardo Carnicer et al.   ANTIOXIDANTS & REDOX SIGNALING

A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo

(2012) Jennifer Davis et al.   DEVELOPMENTAL CELL

Direct Binding and Regulation of RhoA Protein by Cyclic GMP-dependent Protein Kinase Iα

(2012) Mikio Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myofibroblast-mediated mechanisms of pathological remodelling of the heart

(2012) Karl T. Weber et al.   Nature Reviews Cardiology

The Soluble Guanylyl Cyclase Activator Bay 58-2667 Selectively Limits Cardiomyocyte Hypertrophy

(2012) Jennifer C. Irvine et al.   PLoS One

Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity

(2012) Ceng Luo et al.   PLOS BIOLOGY

Soluble Guanylate Cyclase as an Emerging Therapeutic Target in Cardiopulmonary Disease

(2011) Johannes-Peter Stasch et al.   CIRCULATION

Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I

(2011) Stefan Frantz et al.   EUROPEAN HEART JOURNAL

cGMP/PKG pathway mediates myocardial postconditioning protection in rat hearts by delaying normalization of intracellular acidosis during reperfusion

(2011) Javier Inserte et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Effect of Nesiritide in Patients with Acute Decompensated Heart Failure

(2011) C.M. O'Connor et al.   NEW ENGLAND JOURNAL OF MEDICINE

A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide

(2011) M. Klaiber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditional Overexpression of Neuronal Nitric Oxide Synthase Is Cardioprotective in Ischemia/Reperfusion

(2010) Natalie Burkard et al.   CIRCULATION

Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart

(2010) Hideyuki Kinoshita et al.   CIRCULATION RESEARCH

Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias

(2010) Akihiro Yasoda et al.   ENDOCRINE JOURNAL

Phosphorylation of TRPC6 Channels at Thr69Is Required for Anti-hypertrophic Effects of Phosphodiesterase 5 Inhibition

(2010) Motohiro Nishida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes

(2010) R. Lukowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphodiesterase-5 Inhibitor, Tadalafil, Protects Against Myocardial Ischemia/Reperfusion Through Protein-Kinase G-Dependent Generation of Hydrogen Sulfide

(2009) F. N. Salloum et al.   CIRCULATION

Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart

(2009) Hiroyuki Masuyama et al.   HYPERTENSION RESEARCH

Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice

(2009) Eiki Takimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation

(2009) Norimichi Koitabashi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Intramitochondrial signaling: interactions among mitoKATP, PKCε, ROS, and MPT

(2008) Alexandre D. T. Costa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac Myocyte–Specific Expression of Inducible Nitric Oxide Synthase Protects Against Ischemia/Reperfusion Injury by Preventing Mitochondrial Permeability Transition

(2008) Matthew B. West et al.   CIRCULATION

Regulator of G-Protein Signaling Subtype 4 Mediates Antihypertrophic Effect of Locally Secreted Natriuretic Peptides in the Heart

(2008) Takeshi Tokudome et al.   CIRCULATION

Cyclic GMP/Protein Kinase G Phosphorylation of Smad3 Blocks Transforming Growth Factor-β–Induced Nuclear Smad Translocation

(2008) Iain L.O. Buxton et al.   CIRCULATION RESEARCH

Probing the Interaction between the Coiled Coil Leucine Zipper of cGMP-dependent Protein Kinase Iα and the C Terminus of the Myosin Binding Subunit of the Myosin Light Chain Phosphatase

(2008) Alok K. Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase G-dependent Cardioprotective Mechanism of Phosphodiesterase-5 Inhibition Involves Phosphorylation of ERK and GSK3β

(2008) Anindita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric oxide-cGMP-protein kinase G pathway negatively regulates vascular transient receptor potential channel TRPC6

(2008) Shinichi Takahashi et al.   JOURNAL OF PHYSIOLOGY-LONDON

High blood pressure arising from a defect in vascular function

(2008) S. K. Michael et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atrial Natriuretic Peptide Inhibits Transforming Growth Factor β–Induced Smad Signaling and Myofibroblast Transformation in Mouse Cardiac Fibroblasts

(2007) Peng Li et al.   CIRCULATION RESEARCH