Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD)

Diabetes Reduces Severity of Aortic Aneurysms Depending on the Presence of Cell Division Autoantigen 1 (CDA1)

(2018) Jiaze Li et al.   DIABETES

The relaxin receptor as a therapeutic target – perspectives from evolution and drug targeting

(2018) Ross A.D. Bathgate et al.   PHARMACOLOGY & THERAPEUTICS

Targeting the CDA1/CDA1BP1 Axis Retards Renal Fibrosis in Experimental Diabetic Nephropathy

(2018) Zhonglin Chai et al.   DIABETES

Selective activation of epidermal growth factor receptor in renal proximal tubule induces tubulointerstitial fibrosis

(2017) Jessica M. Overstreet et al.   FASEB JOURNAL

Association Between Diabetes and Cause-Specific Mortality in Rural and Urban Areas of China

(2017) Fiona Bragg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Perioperative THR-184 and AKI after Cardiac Surgery

(2017) Jonathan Himmelfarb et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Blocking TGF-βandβ-Catenin Epithelial Crosstalk Exacerbates CKD

(2017) Stellor Nlandu-Khodo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

(2017) Ying-Ying Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Recombinant α-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy

(2017) Ming Chang Hu et al.   KIDNEY INTERNATIONAL

Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice

(2017) Malte Kölling et al.   MOLECULAR THERAPY

Pirfenidone suppresses MAPK signalling pathway to reverse epithelial-mesenchymal transition and renal fibrosis

(2017) Zhenzhen Li et al.   NEPHROLOGY

Novel Anti-fibrotic Therapies

(2017) Benita L. McVicker et al.   Frontiers in Pharmacology

Usefulness of the Hepatocyte Growth Factor as a Predictor of Mortality in Patients Hospitalized With Acute Heart Failure Regardless of Ejection Fraction

(2016) Juan-Ignacio Pérez-Calvo et al.   AMERICAN JOURNAL OF CARDIOLOGY

Epidermal Growth Factor Receptor Transactivation: Mechanisms, Pathophysiology, and Potential Therapies in the Cardiovascular System

(2016) Steven J. Forrester et al.   Annual Review of Pharmacology and Toxicology

Matrix metalloproteinase 9 induces endothelial-mesenchymal transition via Notch activation in human kidney glomerular endothelial cells

(2016) Ye Zhao et al.   BMC CELL BIOLOGY

Decreased plasma α-Klotho predict progression of nephropathy with type 2 diabetic patients

(2016) Sang Soo Kim et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Anti–TGF-β1 Antibody Therapy in Patients with Diabetic Nephropathy

(2016) James Voelker et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The epidermal growth factor receptor pathway in chronic kidney diseases

(2016) Laura R. Harskamp et al.   Nature Reviews Nephrology

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria

(2016) Xiaoyan Liang et al.   PLoS One

Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways

(2016) Kunxin Luo   Cold Spring Harbor Perspectives in Biology

Structural Biology and Evolution of the TGF-β Family

(2016) Andrew P. Hinck et al.   Cold Spring Harbor Perspectives in Biology

Non-Smad Signaling Pathways of the TGF-β Family

(2016) Ying E. Zhang   Cold Spring Harbor Perspectives in Biology

The Discovery and Early Days of TGF-β: A Historical Perspective

(2016) Harold L. Moses et al.   Cold Spring Harbor Perspectives in Biology

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis

(2016) Xiao-Ming Meng et al.   Cell Death & Disease

Relationship between Estimated Glomerular Filtration Rate and Cardiovascular Mortality in a Japanese Cohort with Long-Term Follow-Up

(2016) Kei Nagai et al.   PLoS One

TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions

(2016) Xiaofeng Chen et al.   PLoS One

Klotho attenuates renal hypertrophy and glomerular injury in Ins2Akita diabetic mice

(2015) Hiroyuki Kadoya et al.   Clinical and Experimental Nephrology

BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy

(2015) Rui Xi Li et al.   CLINICAL SCIENCE

50 years forward: mechanisms of hyperglycaemia-driven diabetic complications

(2015) Nicholas D. F. Russell et al.   DIABETOLOGIA

Expression of bone morphogenetic proteins 4, 6 and 7 is downregulated in kidney allografts with interstitial fibrosis and tubular atrophy

(2015) Vesna Furic-Cunko et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

(2015) M. A. Venkatachalam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Relaxin-2 Does Not Ameliorate Nephropathy in an Experimental Model of Type-1 Diabetes

(2015) Thomas Bernd Dschietzig et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells

(2015) Surekha Neelisetty et al.   KIDNEY INTERNATIONAL

Origin of myofibroblasts and cellular events triggering fibrosis

(2015) Matthias Mack et al.   KIDNEY INTERNATIONAL

Diverse origins of the myofibroblast—implications for kidney fibrosis

(2015) Lucas L. Falke et al.   Nature Reviews Nephrology

Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease

(2015) Merlin C. Thomas et al.   Nature Reviews Nephrology

Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice

(2015) Catherine K. Hathaway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smad7 protects against chronic aristolochic acid nephropathy in mice

(2015) Xiao-Yu Dai et al.   Oncotarget

Role of bone morphogenetic protein-7 in renal fibrosis

(2015) Rui Xi Li et al.   Frontiers in Physiology

Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in Endoplasmic Reticulum Stress and an Increase in Autophagy

(2014) Ming-Zhi Zhang et al.   DIABETES

Diabetic Kidney Disease: A Report From an ADA Consensus Conference

(2014) Katherine R. Tuttle et al.   DIABETES CARE

Antiproteinuric effect of pirfenidone in a rat model of anti-glomerular basement membrane glomerulonephritis

(2014) Koji Takakura et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma

(2014) Tatsuo Kido et al.   HUMAN PATHOLOGY

GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF- -Induced Smad3 Phosphorylation

(2014) J. Ai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Curtailing Endothelial TGF-  Signaling Is Sufficient to Reduce Endothelial-Mesenchymal Transition and Fibrosis in CKD

(2014) S. Xavier et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy Regulates TGF-  Expression and Suppresses Kidney Fibrosis Induced by Unilateral Ureteral Obstruction

(2014) Y. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

(2014) Bryna S. Man Chow et al.   KIDNEY INTERNATIONAL

Smad3 signaling activates bone marrow-derived fibroblasts in renal fibrosis

(2014) Jiyuan Chen et al.   LABORATORY INVESTIGATION

Inflammatory processes in renal fibrosis

(2014) Xiao-Ming Meng et al.   Nature Reviews Nephrology

Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury

(2014) G. Canaud et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Changes in Diabetes-Related Complications in the United States, 1990–2010

(2014) Edward W. Gregg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes

(2014) Lakhmir S. Chawla et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of Epithelial Repair and Regeneration After Acute Kidney Injury

(2014) Katja Berger et al.   SEMINARS IN NEPHROLOGY

Circulating α-Klotho Levels in CKD and Relationship to Progression

(2013) Hyoung Rae Kim et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia/reperfusion injury

(2013) Hee-Seong Jang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species

(2013) Rohan Samarakoon et al.   CELLULAR SIGNALLING

microRNA in the development of diabetic complications

(2013) Aaron D. McClelland et al.   CLINICAL SCIENCE

miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes

(2013) X. Zhong et al.   DIABETOLOGIA

Genetic Deficiency of Anti-Aging GeneKlothoExacerbates Early Nephropathy in STZ-Induced Diabetes in Male Mice

(2013) Yi Lin et al.   ENDOCRINOLOGY

Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury

(2013) Massimo Collino et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Genetic Deletion of Cell Division Autoantigen 1 Retards Diabetes-Associated Renal Injury

(2013) Z. Chai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epithelial Cell TGF  Signaling Induces Acute Tubular Injury and Interstitial Inflammation

(2013) M. E. Gentle et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kidney Disease and Increased Mortality Risk in Type 2 Diabetes

(2013) M. Afkarian et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MicroRNA-214 Antagonism Protects against Renal Fibrosis

(2013) L. Denby et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling

(2013) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of epidermal growth factor receptor in acute and chronic kidney injury

(2013) Jinhua Tang et al.   KIDNEY INTERNATIONAL

Chronic kidney disease: global dimension and perspectives

(2013) Vivekanand Jha et al.   LANCET

Evolving importance of kidney disease: from subspecialty to global health burden

(2013) Kai-Uwe Eckardt et al.   LANCET

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

The effect of RAAS blockade on the progression of diabetic nephropathy

(2013) Sara S. Roscioni et al.   Nature Reviews Nephrology

Remnant nephron physiology and the progression of chronic kidney disease

(2013) H. William Schnaper   PEDIATRIC NEPHROLOGY

Relaxin Family Peptides and Their Receptors

(2013) R. A. D. Bathgate et al.   PHYSIOLOGICAL REVIEWS

The Anti-fibrotic Hormone Relaxin is not Reno-protective, Despite Being Active, in an Experimental Model of Type 1 Diabetes

(2013) Su Wong et al.   PROTEIN AND PEPTIDE LETTERS

Renal and Extrarenal Actions of Klotho

(2013) Ming Chang Hu et al.   SEMINARS IN NEPHROLOGY

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

(2012) Ching-Fang Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of the TGF-β/BMP-7/Smad pathways in renal diseases

(2012) Xiao-Ming Meng et al.   CLINICAL SCIENCE

Inflammation and the pathogenesis of diabetic nephropathy

(2012) Jun Wada et al.   CLINICAL SCIENCE

Telmisartan Exerts Renoprotective Actions via Peroxisome Proliferator-Activated Receptor-γ/Hepatocyte Growth Factor Pathway Independent of Angiotensin II Type 1 Receptor Blockade

(2012) Hiroshi Kusunoki et al.   HYPERTENSION

Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation

(2012) Hui Yao Lan   International Journal of Biological Sciences

Deleting the TGF-  Receptor Attenuates Acute Proximal Tubule Injury

(2012) L. Gewin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genetic or Pharmacologic Blockade of EGFR Inhibits Renal Fibrosis

(2012) N. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion

(2012) Osamu Asai et al.   KIDNEY INTERNATIONAL

Prevalence of chronic kidney disease in China: a cross-sectional survey

(2012) Luxia Zhang et al.   LANCET

Smad7 suppresses renal fibrosis via altering expression of TGF-β/Smad3-regulated microRNAs

(2012) Arthur C.K. Chung et al.   MOLECULAR THERAPY

Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

(2012) Hikaru Sugimoto et al.   NATURE MEDICINE

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways

(2012) B. N. Chau et al.   Science Translational Medicine

How Many Ways Can a Podocyte Die?

(2012) Pierre-Louis Tharaux et al.   SEMINARS IN NEPHROLOGY

Can We Target Tubular Damage to Prevent Renal Function Decline in Diabetes?

(2012) Joseph V. Bonventre   SEMINARS IN NEPHROLOGY

Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2

(2011) Christine E. Eyler et al.   CELL

Role of TGF-β in chronic kidney disease: an integration of tubular, glomerular and vascular effects

(2011) Francisco J. López-Hernández et al.   CELL AND TISSUE RESEARCH

Mechanisms of fibrosis: the role of the pericyte

(2011) Claudia Schrimpf et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Diabetes Complications: The MicroRNA Perspective

(2011) P. Kantharidis et al.   DIABETES

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Hepatocyte Growth Factor Attenuates Transforming Growth Factor-β-Angiotensin II Crosstalk Through Inhibition of the PTEN/Akt Pathway

(2011) Kazuma Iekushi et al.   HYPERTENSION

Fibroblasts and myofibroblasts in renal fibrosis

(2011) Soma Meran et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

(2011) Shigehiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro

(2011) Xiao-Ming Meng et al.   JOURNAL OF PATHOLOGY

EGFR Signaling Promotes TGF -Dependent Renal Fibrosis

(2011) J. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pirfenidone for Diabetic Nephropathy

(2011) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis

(2011) X. Zhong et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Scar wars: mapping the fate of epithelial–mesenchymal–myofibroblast transition

(2011) Susan E. Quaggin et al.   KIDNEY INTERNATIONAL

A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis

(2011) Howard Trachtman et al.   KIDNEY INTERNATIONAL

Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro

(2011) Xiao-Ming Meng et al.   KIDNEY INTERNATIONAL

Targeted Deletion of CASK-Interacting Nucleosome Assembly Protein Causes Higher Locomotor and Exploratory Activities

(2011) Wen-Chuan Chung et al.   NEUROSIGNALS

Investigating mechanisms of chronic kidney disease in mouse models

(2011) Allison A. Eddy et al.   PEDIATRIC NEPHROLOGY

TSPYL2 Is Important for G1 Checkpoint Maintenance upon DNA Damage

(2011) Kin Pong Tao et al.   PLoS One

Preservation of Kidney Function with Combined Inhibition of NADPH Oxidase and Angiotensin-Converting Enzyme in Diabetic Nephropathy

(2010) Vicki Thallas-Bonke et al.   AMERICAN JOURNAL OF NEPHROLOGY

Transforming Growth Factor-β1 Induces Smad3-Dependent β1 Integrin Gene Expression in Epithelial-to-Mesenchymal Transition during Chronic Tubulointerstitial Fibrosis

(2010) Yi-Chun Yeh et al.   AMERICAN JOURNAL OF PATHOLOGY

Bone Morphogenetic Protein-7 Inhibits Proximal Tubular Epithelial Cell Smad3 Signaling via Increased SnoN Expression

(2010) Dong Dong Luo et al.   AMERICAN JOURNAL OF PATHOLOGY

Tubular Overexpression of Transforming Growth Factor-β1 Induces Autophagy and Fibrosis but Not Mesenchymal Transition of Renal Epithelial Cells

(2010) Robert Koesters et al.   AMERICAN JOURNAL OF PATHOLOGY

Glycation in diabetic nephropathy

(2010) Josephine M. Forbes et al.   AMINO ACIDS

Cellular Maintenance and Repair of the Kidney

(2010) Jian-Kan Guo et al.   Annual Review of Physiology

E-Cadherin Expression Is Regulated by miR-192/215 by a Mechanism That Is Independent of the Profibrotic Effects of Transforming Growth Factor- 

(2010) B. Wang et al.   DIABETES

Blockade of Endothelial-Mesenchymal Transition by a Smad3 Inhibitor Delays the Early Development of Streptozotocin-Induced Diabetic Nephropathy

(2010) J. Li et al.   DIABETES

In the absence of renal disease, 20 year mortality risk in type 1 diabetes is comparable to that of the general population: a report from the Pittsburgh Epidemiology of Diabetes Complications Study

(2010) T. J. Orchard et al.   DIABETOLOGIA

Antifibrotic Properties of Relaxin:In VivoMechanism of Action in Experimental Renal Tubulointerstitial Fibrosis

(2010) Tim D. Hewitson et al.   ENDOCRINOLOGY

Cellular and molecular basis for the regulation of inflammation by TGF- 

(2010) A. Yoshimura et al.   JOURNAL OF BIOCHEMISTRY

Role of inflammation in túbulo-interstitial damage associated to obstructive nephropathy

(2010) María T Grande et al.   Journal of Inflammation-London

Mechanisms of Tubulointerstitial Fibrosis

(2010) M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Smad2 Protects against TGF- /Smad3-Mediated Renal Fibrosis

(2010) X. M. Meng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of ion channels by secreted Klotho: mechanisms and implications

(2010) Chou-Long Huang   KIDNEY INTERNATIONAL

An integrative view on the role of TGF-β in the progressive tubular deletion associated with chronic kidney disease

(2010) Omar García-Sánchez et al.   KIDNEY INTERNATIONAL

A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy

(2010) Maoyin Pang et al.   KIDNEY INTERNATIONAL

Cell division autoantigen 1 enhances signaling and the profibrotic effects of transforming growth factor-β in diabetic nephropathy

(2010) Yugang Tu et al.   KIDNEY INTERNATIONAL

Early recognition and prevention of chronic kidney disease

(2010) Matthew T James et al.   LANCET

Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha

(2010) Brandi N. Davis et al.   MOLECULAR CELL

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Expression of Transforming Growth Factor-β1 Limits Renal Ischemia-Reperfusion Injury

(2010) Qiunong Guan et al.   TRANSPLANTATION

Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis

(2010) Carsten P Bramlage et al.   BMC Nephrology

Relaxin Family Peptide Receptor 1 Activation Stimulates Peroxisome Proliferator-Activated Receptor Gamma

(2009) Sudhir Singh et al.   Annals of the New York Academy of Sciences

The Presence and Severity of Chronic Kidney Disease Predicts All-Cause Mortality in Type 1 Diabetes

(2009) P.-H. Groop et al.   DIABETES

Cell division autoantigen 1 plays a profibrotic role by modulating downstream signalling of TGF-β in a murine diabetic model of atherosclerosis

(2009) Y. Pham et al.   DIABETOLOGIA

Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression via Transforming Growth Factor–β–Dependent and –Independent Smad Pathways

(2009) Fuye Yang et al.   HYPERTENSION

Association Between Renal Function and Cardiovascular Disease in Patients With Left Ventricular Hypertrophy. VIIDA Study

(2009) Lorenzo Fácila et al.   Journal of Clinical Hypertension

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Pirfenidone Is Renoprotective in Diabetic Kidney Disease

(2009) S. P. RamachandraRao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Circulating transforming growth factor-β1 levels and the risk for kidney disease in African Americans

(2009) Manikkam Suthanthiran et al.   KIDNEY INTERNATIONAL

Fibroblast activation and myofibroblast generation in obstructive nephropathy

(2009) María T. Grande et al.   Nature Reviews Nephrology

Mechanical forces and TGF 1 reduce podocyte adhesion through  3 1 integrin downregulation

(2009) C. Dessapt et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Connective Tissue Growth Factor-(CTGF, CCN2) – A Marker, Mediator and Therapeutic Target for Renal Fibrosis

(2009) Mysore K. Phanish et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Role of transforming growth factor-β superfamily signaling pathways in human disease

(2008) Kelly J. Gordon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Differentially expressed nucleolar transforming growth factor-β1 target (DENTT) exhibits an inhibitory role on tumorigenesis

(2008) Lana E. Kandalaft et al.   CARCINOGENESIS

Ski and SnoN, potent negative regulators of TGF-β signaling

(2008) Julien Deheuninck et al.   CELL RESEARCH

TGF-β signaling in vascular biology and dysfunction

(2008) Marie-José Goumans et al.   CELL RESEARCH

The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology

(2008) Fenghua Zeng et al.   EXPERIMENTAL CELL RESEARCH

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

(2008) Ishanee Mookerjee et al.   FASEB JOURNAL

Latent TGF- 1 Protects Against Crescentic Glomerulonephritis

(2008) X. R. Huang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

(2008) E. M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation

(2008) Gisselle Carvajal et al.   KIDNEY INTERNATIONAL

Activation of Erk1/2 and Akt following unilateral ureteral obstruction

(2008) Ana B. Rodríguez-Peña et al.   KIDNEY INTERNATIONAL

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

BMP-7 fails to attenuate TGF- 1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells

(2008) P. L. Dudas et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice

(2008) A. C. K. Chung et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

BMP-7 and Proximal Tubule Epithelial Cells: Activation of Multiple Signaling Pathways Reveals a Novel Anti-fibrotic Mechanism

(2008) Reza Motazed et al.   PHARMACEUTICAL RESEARCH

A New Look at Platelet-Derived Growth Factor in Renal Disease

(2007) J. Floege et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oral administration of GW788388, an inhibitor of TGF-β type I and II receptor kinases, decreases renal fibrosis

(2007) M. Petersen et al.   KIDNEY INTERNATIONAL