ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

(2019) Amer Alam et al.   SCIENCE

Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors

(2019) Reza Dastvan et al.   SCIENCE

Large-scale purification of functional human P-glycoprotein (ABCB1)

(2019) Krishnamachary Nandigama et al.   PROTEIN EXPRESSION AND PURIFICATION

Conformational dynamics of P-glycoprotein in lipid nanodiscs and detergent micelles reveal complex motions on a wide time scale

(2018) Mavis Jiarong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

(2018) Amer Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation

(2018) Youngjin Kim et al.   SCIENCE

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1)

(2018) Andaleeb Sajid et al.   PLoS One

Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies

(2018) Jack Wright et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer–associated P-glycoprotein during ATP hydrolysis

(2017) Maria E. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions

(2017) Suneet Shukla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

(2017) Brandy Verhalen et al.   NATURE

ATP-binding Cassette Exporters: Structure and Mechanism with a Focus on P-glycoprotein and MRP1

(2017) Maite Rocío Arana et al.   CURRENT MEDICINAL CHEMISTRY

Drug–protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein

(2016) Eduardo E. Chufan et al.   BIOCHEMICAL PHARMACOLOGY

ABC transporters as mediators of drug resistance and contributors to cancer cell biology

(2016) Jamie I. Fletcher et al.   DRUG RESISTANCE UPDATES

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity

(2016) Lothar Esser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter

(2016) Michael L. Oldham et al.   NATURE

Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein

(2015) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function

(2014) Frances Jane Sharom   Frontiers in Oncology

Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids

(2013) Naomi L. Pollock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Thermal Denaturation Assays in Chemical Biology

(2011) Guillermo Senisterra et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Simple screening method for improving membrane protein thermostability

(2011) Romina Mancusso et al.   METHODS

A Gene Optimization Strategy that Enhances Production of Fully Functional P-Glycoprotein in Pichia pastoris

(2011) Jiangping Bai et al.   PLoS One

Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1

(2010) Irina Protasevich et al.   PROTEIN SCIENCE