Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation

The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy

(2019) Subhash Mehto et al.   MOLECULAR CELL

Cis-khellactone inhibited the proinflammatory macrophages via promoting autophagy to ameliorate imiquimod-induced psoriasis

(2019) Lili Feng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autophagy balances inflammation in innate immunity

(2018) Vojo Deretic et al.   Autophagy

PI3K/AKT/mTOR activation and autophagy inhibition plays a key role in increased cholesterol during IL-17A mediated inflammatory response in psoriasis

(2018) Pallavi Varshney et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review

(2018) Domenico Plantone et al.   CLINICAL DRUG INVESTIGATION

GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion

(2018) Xiaoyan Zhang et al.   DEVELOPMENTAL CELL

Lysosomes Support the Degradation, Signaling, and Mitochondrial Metabolism Necessary for Human Epidermal Differentiation

(2018) Christine L. Monteleon et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

A new hypothesis for Parkinson’s disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomics

(2018) Julia Obergasteiger et al.   Molecular Neurodegeneration

The Therapeutic and Pathogenic Role of Autophagy in Autoimmune Diseases

(2018) Heng Yin et al.   Frontiers in Immunology

Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease

(2016) Sung Min Son et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88

(2016) Fenli Shao et al.   BIOCHEMICAL PHARMACOLOGY

Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy

(2016) Tomonori Kimura et al.   EMBO JOURNAL

Constitutive Autophagy and Nucleophagy during Epidermal Differentiation

(2016) Olufolake Akinduro et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production

(2016) Satveer K. Mahil et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Proinflammatory effect of high-mobility group protein B1 on keratinocytes: an autocrine mechanism underlying psoriasis development

(2016) Weigang Zhang et al.   JOURNAL OF PATHOLOGY

High mobility group box 1 is increased in the sera of psoriatic patients with disease progression

(2016) C. Bergmann et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Lycorine Downregulates HMGB1 to Inhibit Autophagy and Enhances Bortezomib Activity in Multiple Myeloma

(2016) Mridul Roy et al.   Theranostics

Inhibition of MEK/ERK activation attenuates autophagy and potentiates pemetrexed-induced activity against HepG2 hepatocellular carcinoma cells

(2015) Yongxi Tong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

N-linked glycosylation plays a crucial role in the secretion of HMGB1

(2015) Young Hun Kim et al.   JOURNAL OF CELL SCIENCE

Autophagy and autophagy-related proteins in the immune system

(2015) Shusaku T Shibutani et al.   NATURE IMMUNOLOGY

Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation

(2015) Katja Derkow et al.   PLoS One

Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity

(2015) Masashi Kanayama et al.   Nature Communications

Adiponectin regulates psoriasiform skin inflammation by suppressing IL-17 production from γδ-T cells

(2015) Sayaka Shibata et al.   Nature Communications

Immunology of Psoriasis

(2014) Michelle A. Lowes et al.   Annual Review of Immunology

The significant role of autophagy in the granular layer in normal skin differentiation and hair growth

(2014) Nagisa Yoshihara et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

iASPP is a novel autophagy inhibitor in keratinocytes

(2014) A. Chikh et al.   JOURNAL OF CELL SCIENCE

IL-37 Ameliorates the Inflammatory Process in Psoriasis by Suppressing Proinflammatory Cytokine Production

(2014) X. Teng et al.   JOURNAL OF IMMUNOLOGY

Skin-Resident T Cells Sense Ultraviolet Radiation-Induced Injury and Contribute to DNA Repair

(2014) A. S. MacLeod et al.   JOURNAL OF IMMUNOLOGY

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Increased HMGB1 serum levels and altered HMGB1 expression in patients with psoriasis vulgaris

(2013) Tao Chen et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

IL-23-Independent Induction of IL-17 from   T Cells and Innate Lymphoid Cells Promotes Experimental Intraocular Neovascularization

(2013) E. Hasegawa et al.   JOURNAL OF IMMUNOLOGY

The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics

(2013) R Kang et al.   ONCOGENE

Polymorphisms in the ATG16L1 Gene are Associated with Psoriasis Vulgaris

(2012) K Douroudis et al.   ACTA DERMATO-VENEREOLOGICA

Autophagy and the Immune System

(2012) Petric Kuballa et al.   Annual Review of Immunology

Selective Autophagy of the Adaptor Protein Bcl10 Modulates T Cell Receptor Activation of NF-κB

(2012) Suman Paul et al.   IMMUNITY

Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice

(2012) Stanislav Pantelyushin et al.   JOURNAL OF CLINICAL INVESTIGATION

Critical role of the interleukin-23//T-helper 17 cell axis in the pathogenesis of psoriasis

(2012) Kimiko NAKAJIMA   JOURNAL OF DERMATOLOGY

An Alternative Pathway of Imiquimod-Induced Psoriasis-Like Skin Inflammation in the Absence of Interleukin-17 Receptor A Signaling

(2012) Khalifa El Malki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation

(2012) Vojo Deretic et al.   TRENDS IN CELL BIOLOGY

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

(2011) J R Kovacs et al.   CELL DEATH AND DIFFERENTIATION

Functions of skin-resident γδ T cells

(2011) Amanda S. MacLeod et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy and cytokines

(2011) James Harris   CYTOKINE

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

(2011) Yihua Cai et al.   IMMUNITY

HMGB1 release by inflammasomes

(2011) Lieselotte Vande Walle et al.   Virulence

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation

(2010) Reto Huggenberger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy Negatively Regulates Keratinocyte Inflammatory Responses via Scaffolding Protein p62/SQSTM1

(2010) H.-M. Lee et al.   JOURNAL OF IMMUNOLOGY

Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1 , and TNF-  Recapitulates Some Features of Psoriasis

(2010) K. Guilloteau et al.   JOURNAL OF IMMUNOLOGY

Pro-autophagic signal induction by bacterial pore-forming toxins

(2010) Nicole Kloft et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells

(2010) Trond Aasen et al.   Nature Protocols

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice

(2008) Ulrike Lichti et al.   Nature Protocols