Proinflammatory effect of high-mobility group protein B1 on keratinocytes: an autocrine mechanism underlying psoriasis development

The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome

(2016) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

The Inflammatory Response in Psoriasis: a Comprehensive Review

(2016) Yaxiong Deng et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

IL-18/IL-1/IL-17A axis: A novel therapeutic target for neonatal sepsis?

(2016) Alan S. Cross   CYTOKINE

CD4+T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm

(2016) Kiyoshi Hirahara et al.   INTERNATIONAL IMMUNOLOGY

HMGB1Modulates the Treg/Th17 Ratio in Atherosclerotic Patients

(2016) Jia-wang Ding et al.   Journal of Atherosclerosis and Thrombosis

RAC1 activation drives pathologic interactions between the epidermis and immune cells

(2016) Mårten C.G. Winge et al.   JOURNAL OF CLINICAL INVESTIGATION

High mobility group box 1 is increased in the sera of psoriatic patients with disease progression

(2016) C. Bergmann et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

The protective effect of neutralizing high-mobility group box1 against chronic cyclosporine nephrotoxicity in mice

(2016) Hoon Suk Park et al.   TRANSPLANT IMMUNOLOGY

HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development

(2016) Zhaoliang Su et al.   Scientific Reports

In vivorelative quantitative proteomics reveals HMGB1 as a downstream mediator of oestrogen-stimulated keratinocyte migration

(2015) Jung U Shin et al.   EXPERIMENTAL DERMATOLOGY

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

(2015) José A. García et al.   FASEB JOURNAL

Interleukin 18 augments growth ability via NF-κB and p38/ATF2 pathways by targeting cyclin B1, cyclin B2, cyclin A2, and Bcl-2 in BRL-3A rat liver cells

(2015) Jihong Zhang et al.   GENE

Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions

(2015) Dhavalkumar D. Patel et al.   IMMUNITY

Helicobacter urease–induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma

(2015) Katrin N. Koch et al.   JOURNAL OF CLINICAL INVESTIGATION

Simiao pill ameliorates renal glomerular injury via increasing Sirt1 expression and suppressing NF-κB/NLRP3 inflammasome activation in high fructose-fed rats

(2015) Chun-Hua Ma et al.   JOURNAL OF ETHNOPHARMACOLOGY

Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes

(2015) Yuan Zhang et al.   Journal of Neuroinflammation

HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

(2015) Wei Chi et al.   Journal of Neuroinflammation

Psoriasis

(2015) Wolf-Henning Boehncke et al.   LANCET

Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3+ Treg cell function in the intestine

(2015) O J Harrison et al.   Mucosal Immunology

IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells

(2015) Emmanuella Guenova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1β signaling

(2015) M Zhang et al.   Cell Death & Disease

NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis

(2015) Sha Yan et al.   Nature Communications

High mobility group box 1 contributes to wound healing induced by inhibition of dipeptidylpeptidase 4 in cultured keratinocytes

(2015) Tiziana Sinagra et al.   Frontiers in Pharmacology

Immunology of Psoriasis

(2014) Michelle A. Lowes et al.   Annual Review of Immunology

Interleukin-18 directly protects cortical neurons by activating PI3K/AKT/NF-κB/CREB pathways

(2014) Jia Zhou et al.   CYTOKINE

The functions of HMGB1 depend on molecular localization and post-translational modifications

(2014) U. Andersson et al.   JOURNAL OF INTERNAL MEDICINE

High-mobility group box-1 in sterile inflammation

(2014) A. Tsung et al.   JOURNAL OF INTERNAL MEDICINE

Role of ROS and HMGB1 in Contact Allergen–Induced IL-18 Production in Human Keratinocytes

(2014) Valentina Galbiati et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

UVB Radiation Illuminates the Role of TLR3 in the Epidermis

(2014) Andrew W. Borkowski et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MiR-146a Negatively Regulates TLR2-Induced Inflammatory Responses in Keratinocytes

(2014) Florian Meisgen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

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(2014) Fleur Schaper et al.   MOLECULAR MEDICINE

Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

(2014) Lorena Riol-Blanco et al.   NATURE

HMGB1–LPS complex promotes transformation of osteoarthritis synovial fibroblasts to a rheumatoid arthritis synovial fibroblast-like phenotype

(2014) Y Qin et al.   Cell Death & Disease

Increased HMGB1 serum levels and altered HMGB1 expression in patients with psoriasis vulgaris

(2013) Tao Chen et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3-Ser727 phosphorylation as a modulator of transcriptional activity

(2013) Rosa M. Andrés et al.   EXPERIMENTAL DERMATOLOGY

Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis

(2013) Andrew Johnston et al.   HUMAN MOLECULAR GENETICS

High-mobility group box 1 protein (HMGB1) neutralization ameliorates experimental autoimmune encephalomyelitis

(2013) Andrew P. Robinson et al.   JOURNAL OF AUTOIMMUNITY

Interleukin-18, more than a Th1 cytokine

(2013) Daniela Novick et al.   SEMINARS IN IMMUNOLOGY

Aldara activates TLR7-independent immune defence

(2013) Anne Walter et al.   Nature Communications

HMGB1 Promotes the Synthesis of Pro-IL-1β and Pro-IL-18 by Activation of p38 MAPK and NF-κB Through Receptors for Advanced Glycation End-products in Macrophages

(2012) Qiang He et al.   Asian Pacific Journal of Cancer Prevention

ALK+ALCLs induce cutaneous, HMGB-1-dependent IL-8/CXCL8 production by keratinocytes through NF- B activation

(2012) E. Dejean et al.   BLOOD

STAT1 expression and activation is increased in lesional psoriatic skin

(2012) A. Hald et al.   BRITISH JOURNAL OF DERMATOLOGY

Interleukin-18 augments growth ability of primary human melanocytes by PTEN inactivation through the AKT/NF-κB pathway

(2012) Jia Zhou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

IL-1 Family Members IL-18 and IL-33 Upregulate the Inflammatory Potential of Differentiated Human Th1 and Th2 Cultures

(2012) Lars Blom et al.   JOURNAL OF IMMUNOLOGY

IL-18 activation is dependent on Toll-like receptor 4 during renal obstruction

(2012) Audrey C. Rhee et al.   JOURNAL OF SURGICAL RESEARCH

The high mobility group box: the ultimate utility player of a cell

(2012) Christopher S. Malarkey et al.   TRENDS IN BIOCHEMICAL SCIENCES

High-mobility group box family of proteins: ligand and sensor for innate immunity

(2012) Hideyuki Yanai et al.   TRENDS IN IMMUNOLOGY

Psoriasis

(2011) Gayathri K. Perera et al.   Annual Review of Pathology-Mechanisms of Disease

IL-17A Upregulates Keratin 17 Expression in Keratinocytes through STAT1- and STAT3-Dependent Mechanisms

(2011) Xiaowei Shi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

The role of innate immunity activation in house dust mite allergy

(2011) Alain Jacquet   TRENDS IN MOLECULAR MEDICINE