The Hallmarks of Severe Pulmonary Arterial Hypertension: The Cancer Hypothesis - Ten years later

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance

(2019) Jonathan Cooper et al.   CANCER CELL

Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence.

(2019) Diederik E van der Feen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Epigenetic Inheritance Underlying Pulmonary Arterial Hypertension

(2019) Claudio Napoli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

(2019) Maisa C. Takenaka et al.   NATURE NEUROSCIENCE

Role of the Aryl Hydrocarbon Receptor/ARNT/Cytochrome P450 System in Pulmonary Vascular Diseases

(2019) Grazyna Kwapiszewska et al.   CIRCULATION RESEARCH

Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation

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A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

(2019) Swati Dabral et al.   Nature Communications

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

(2019) Astrid Weiss et al.   Nature Communications

Obesity and Breast Cancer: Role of Leptin

(2019) Flora Sánchez-Jiménez et al.   Frontiers in Oncology

Systemic Lupus Erythematosus and DNA Degradation and Elimination Defects

(2019) Borros Arneth   Frontiers in Immunology

The Light at the End of the Long Pulmonary Hypertension Tunnel Brightens

(2018) Norbert F Voelkel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Potential Role for Exosomal TCTP Export in Vascular Remodeling in Pulmonary Arterial Hypertension

(2018) Elisabet Ferrer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming

(2018) Angelo D'Alessandro et al.   ANTIOXIDANTS & REDOX SIGNALING

Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodeling unaltered in experimental pulmonary hypertension

(2018) Nina Rol et al.   CARDIOVASCULAR RESEARCH

Classical IL-6 signaling: a promising therapeutic target for pulmonary arterial hypertension

(2018) Soni Savai Pullamsetti et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidative stress increases M1dG, a major peroxidation-derived DNA adduct, in mitochondrial DNA

(2018) Orrette R Wauchope et al.   NUCLEIC ACIDS RESEARCH

Pulmonary arterial hypertension: pathogenesis and clinical management

(2018) Thenappan Thenappan et al.   BMJ-British Medical Journal

Pulmonary arterial hypertension: pathogenesis and clinical management

(2018) Thenappan Thenappan et al.   BMJ-British Medical Journal

RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade

(2018) Shanthi Ganesh et al.   MOLECULAR THERAPY

Circulating Endothelial Progenitor Cells Biology and Regenerative Medicine in Pulmonary Vascular Diseases

(2018) Germano Guerra et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

STAT3 mediates resistance to anoikis and promotes invasiveness of nasopharyngeal cancer cells

(2017) Chien-Hung Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway

(2017) Gillian Moore et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases

(2017) Evangelia Pardali et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of stem-cell divisions in cancer risk

(2017) Cristian Tomasetti et al.   NATURE

Lung cancer–associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell–immune cell cross-talk

(2017) Soni Savai Pullamsetti et al.   Science Translational Medicine

Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension

(2017) Robert A. Egnatchik et al.   Pulmonary Circulation

Intrapulmonary Bronchopulmonary Anastomoses and Plexiform Lesions in Idiopathic Pulmonary Arterial Hypertension

(2016) Csaba Galambos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bone Marrow–derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension

(2016) Ling Yan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Enhanced autophagy in pulmonary endothelial cells on exposure to HIV-Tat and morphine: Role in HIV-related pulmonary arterial hypertension

(2016) Pranjali Dalvi et al.   Autophagy

Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2αCLINICAL PERSPECTIVE

(2016) Zhiyu Dai et al.   CIRCULATION

DNA Damage and Pulmonary Hypertension

(2016) Benoît Ranchoux et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

(2016) Thomas Bertero et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-223 reverses experimental pulmonary arterial hypertension

(2015) Jolyane Meloche et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An oxidative DNA “damage” and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression

(2015) Viktor Pastukh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Serum Endostatin Is a Genetically Determined Predictor of Survival in Pulmonary Arterial Hypertension

(2015) Rachel Damico et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Occlusive Lung Arterial Lesions in Endothelial-Targeted, Fas-Induced Apoptosis Transgenic Mice

(2015) Heather Goldthorpe et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II–Associated Pulmonary Arterial Hypertension Through MicroRNA-29–Mediated Modulation of Cellular MetabolismCLINICAL PERSPECTIVE

(2015) Xinping Chen et al.   CIRCULATION

The contribution of tumour-derived exosomes to the hallmarks of cancer

(2015) Katie Meehan et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

High-mobility group box-1 induces vascular remodelling processesviac-Jun activation

(2015) Diana Zabini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases

(2015) J Ngo et al.   Cell Death & Disease

Pulmonary Hypertension after Hematopoietic Stem Cell Transplantation

(2013) Christopher E. Dandoy et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Role for DNA Damage Signaling in Pulmonary Arterial Hypertension

(2013) Jolyane Meloche et al.   CIRCULATION

The Role of Estrogens in Control of Energy Balance and Glucose Homeostasis

(2013) Franck Mauvais-Jarvis et al.   ENDOCRINE REVIEWS

Telomerase: central regulator of all of the hallmarks of cancer

(2013) Kee Chung Low et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pathobiology of pulmonary arterial hypertension and right ventricular failure

(2012) Norbert F. Voelkel et al.   EUROPEAN RESPIRATORY JOURNAL

New Models of Pulmonary Hypertension Based on VEGF Receptor Blockade-Induced Endothelial Cell Apoptosis

(2012) Mark R. Nicolls et al.   Pulmonary Circulation

Cross Talk between Autophagy and Apoptosis in Pulmonary Hypertension

(2012) Yang Jin et al.   Pulmonary Circulation

Copper Dependence of Angioproliferation in Pulmonary Arterial Hypertension in Rats and Humans

(2011) Harm J. Bogaard et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Pulmonary Artery Smooth Muscle Cell Senescence Is a Pathogenic Mechanism for Pulmonary Hypertension in Chronic Lung Disease

(2011) Hibo Noureddine et al.   CIRCULATION RESEARCH

Cellular senescence and tumor suppressor gene p16

(2011) Hani Rayess et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice

(2011) Yannis Hara et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagic Protein LC3B Confers Resistance against Hypoxia-induced Pulmonary Hypertension

(2010) Seon-Jin Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evidence of Dysfunction of Endothelial Progenitors in Pulmonary Arterial Hypertension

(2009) Mark Toshner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE