Mitochondrial function in skeletal myofibers is controlled by a TRF2‐SIRT3 axis over lifetime

PRDX1 and MTH1 cooperate to prevent ROS-mediated inhibition of telomerase

(2018) Wareed Ahmed et al.   GENES & DEVELOPMENT

Telomere shortening is a hallmark of genetic cardiomyopathies

(2018) Alex C. Y. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Trafficking and Processing of Telomerase RNA TERC

(2018) Ying Cheng et al.   Cell Reports

Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging

(2017) Marta Murgia et al.   Cell Reports

Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells

(2017) Hyeung Kim et al.   Cell Discovery

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

(2016) Aneesa Ansari et al.   AGING CELL

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Exercise-induced oxidative stress: past, present and future

(2016) Scott K. Powers et al.   JOURNAL OF PHYSIOLOGY-LONDON

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Oxidative guanine base damage regulates human telomerase activity

(2016) Elise Fouquerel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy

(2016) Alex Chia Yu Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative guanine base damage regulates human telomerase activity

(2016) Elise Fouquerel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase

(2016) Eric Aeby et al.   Cell Reports

Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer

(2016) Wanil Kim et al.   PLOS BIOLOGY

Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish

(2016) Madalena C. Carneiro et al.   PLoS Genetics

SORBS2transcription is activated by telomere position effect–over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy

(2015) Jérôme D. Robin et al.   GENOME RESEARCH

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

(2015) Giulia Milan et al.   Nature Communications

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances

(2014) Jérôme D. Robin et al.   GENES & DEVELOPMENT

Skeletal muscle satellite cells: Mediators of muscle growth during development and implications for developmental disorders

(2014) Sudarshan Dayanidhi et al.   MUSCLE & NERVE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

(2014) Michael M. Mueller et al.   NATURE CELL BIOLOGY

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

(2014) Christopher S Fry et al.   NATURE MEDICINE

Transcriptional outcome of telomere signalling

(2014) Jing Ye et al.   NATURE REVIEWS GENETICS

More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny

(2014) Leyla Vahidi Ferdousi et al.   Stem Cell Research

TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

(2014) Ashley M. Wood et al.   Nature Communications

Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study “Treviso Longeva (TRELONG)”

(2013) Diego Albani et al.   AGE

Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health

(2013) Vassilios N. Kotiadis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

(2013) Georgios Karamanlidis et al.   Cell Metabolism

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

(2013) Irmina Diala et al.   EMBO REPORTS

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

(2013) Annamaria Biroccio et al.   NATURE CELL BIOLOGY

Telomeres shorten at equivalent rates in somatic tissues of adults

(2013) Lily Daniali et al.   Nature Communications

RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression

(2013) Paula Martínez et al.   Cell Reports

Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration

(2013) Brad Kincaid et al.   Frontiers in Aging Neuroscience

Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage

(2012) F. Relaix et al.   DEVELOPMENT

Mitochondrial Localization of Telomeric Protein TIN2 Links Telomere Regulation to Metabolic Control

(2012) Liuh-Yow Chen et al.   MOLECULAR CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

(2011) E C Ferber et al.   CELL DEATH AND DIFFERENTIATION

The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats

(2011) Thomas Simonet et al.   CELL RESEARCH

Human telomeric proteins occupy selective interstitial sites

(2011) Dong Yang et al.   CELL RESEARCH

Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration

(2011) M. M. Murphy et al.   DEVELOPMENT

The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging

(2011) Michael N. Sack   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Mitochondrial Oxidative Phosphorylation Compensation May Preserve Vision in Patients with OPA1-Linked Autosomal Dominant Optic Atrophy

(2011) Nicole J. Van Bergen et al.   PLoS One

Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements

(2009) Christoph Lepper et al.   NATURE

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The longest telomeres: a general signature of adult stem cell compartments

(2008) I. Flores et al.   GENES & DEVELOPMENT

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

(2008) S. Ahmed et al.   JOURNAL OF CELL SCIENCE

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA