Transcriptional outcome of telomere signalling

Telomere length regulates ISG15 expression in human cells

(2016) Zhenjun Lou et al.   Aging-US

Methylated TRF2 associates with the nuclear matrix and serves as a potential biomarker for cellular senescence

(2016) Taylor R. H Mitchell et al.   Aging-US

Rif1 Maintains Telomere Length Homeostasis of ESCs by Mediating Heterochromatin Silencing

(2014) Jiameng Dan et al.   DEVELOPMENTAL CELL

Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex

(2014) S.-i. Hiraga et al.   GENES & DEVELOPMENT

Protein Phosphatase 1 Recruitment by Rif1 Regulates DNA Replication Origin Firing by Counteracting DDK Activity

(2014) Anoushka Davé et al.   Cell Reports

Rif1 Controls DNA Replication Timing in Yeast through the PP1 Phosphatase Glc7

(2014) Stefano Mattarocci et al.   Cell Reports

SIR Proteins and the Assembly of Silent Chromatin in Budding Yeast

(2013) Stephanie Kueng et al.   Annual Review of Genetics

The Major Reverse Transcriptase-Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis

(2013) I. Listerman et al.   CANCER RESEARCH

Rif1 and Rif2 Shape Telomere Function and Architecture through Multivalent Rap1 Interactions

(2013) Tianlai Shi et al.   CELL

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

(2013) Irmina Diala et al.   EMBO REPORTS

Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription

(2013) Deqiang Ding et al.   FASEB JOURNAL

Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence

(2013) J. M. Platt et al.   GENES & DEVELOPMENT

An Investigation of the Effects of the Core Protein Telomerase Reverse Transcriptase on Wnt Signaling in Breast Cancer Cells

(2013) I. Listerman et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomere Length Influences Cancer Cell Differentiation In Vivo

(2013) K. Hirashima et al.   MOLECULAR AND CELLULAR BIOLOGY

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

(2013) Annamaria Biroccio et al.   NATURE CELL BIOLOGY

Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy

(2013) Guido Stadler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

p300-mediated acetylation of TRF2 is required for maintaining functional telomeres

(2013) Yoon Ra Her et al.   NUCLEIC ACIDS RESEARCH

Highly expressed loci are vulnerable to misleading ChIP localization of multiple unrelated proteins

(2013) L. Teytelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Telomerase: central regulator of all of the hallmarks of cancer

(2013) Kee Chung Low et al.   TRENDS IN BIOCHEMICAL SCIENCES

FOXO3 Shares Common Targets with ASCL1 Genome-wide and Inhibits ASCL1-Dependent Neurogenesis

(2013) Ashley E. Webb et al.   Cell Reports

Nontelomeric Role for Rap1 in Regulating Metabolism and Protecting against Obesity

(2013) Frank Yeung et al.   Cell Reports

RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression

(2013) Paula Martínez et al.   Cell Reports

Environmental Stresses Disrupt Telomere Length Homeostasis

(2013) Gal Hagit Romano et al.   PLoS Genetics

Telomeres, A Busy Platform for Cell Signaling

(2013) Laura Gardano et al.   Frontiers in Oncology

One Identity or More for Telomeres?

(2013) Marie-Josèphe Giraud-Panis et al.   Frontiers in Oncology

PRL-3 activates NF-κB signaling pathway by interacting with RAP1

(2012) Shenyi Lian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells

(2012) Daniela Cornacchia et al.   EMBO JOURNAL

Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast

(2012) A. Tazumi et al.   GENES & DEVELOPMENT

Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the Telomere

(2012) N. Özlem Arat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational modifications of TRF1 and TRF2 and their roles in telomere maintenance

(2012) John R. Walker et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Alternatively Spliced Telomerase Reverse Transcriptase Variants Lacking Telomerase Activity Stimulate Cell Proliferation

(2012) R. Hrdlickova et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial Localization of Telomeric Protein TIN2 Links Telomere Regulation to Metabolic Control

(2012) Liuh-Yow Chen et al.   MOLECULAR CELL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Telomerase directly regulates NF-κB-dependent transcription

(2012) Arkasubhra Ghosh et al.   NATURE CELL BIOLOGY

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

(2012) Makoto T Hayashi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α

(2012) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRF2 Controls Telomeric Nucleosome Organization in a Cell Cycle Phase-Dependent Manner

(2012) Alessandra Galati et al.   PLoS One

Telomere length in early life predicts lifespan

(2012) B. J. Heidinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly

(2012) Laure Crabbe et al.   Cell Reports

Regulating Repression: Roles for the Sir4 N-Terminus in Linker DNA Protection and Stabilization of Epigenetic States

(2012) Stephanie Kueng et al.   PLoS Genetics

Telomere length and type 2 diabetes in males, a premature aging syndrome

(2011) Blanca Murillo-Ortiz et al.   Aging Male

The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats

(2011) Thomas Simonet et al.   CELL RESEARCH

Human telomeric proteins occupy selective interstitial sites

(2011) Dong Yang et al.   CELL RESEARCH

Dynamics of Sir3 spreading in budding yeast: secondary recruitment sites and euchromatic localization

(2011) Marta Radman-Livaja et al.   EMBO JOURNAL

Clustering heterochromatin: Sir3 promotes telomere clustering independently of silencing in yeast

(2011) Myriam Ruault et al.   JOURNAL OF CELL BIOLOGY

Phenotypes in mTERT+/- and mTERT-/- Mice Are Due to Short Telomeres, Not Telomere-Independent Functions of Telomerase Reverse Transcriptase

(2011) M. A. Strong et al.   MOLECULAR AND CELLULAR BIOLOGY

Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions

(2011) Ci Chu et al.   MOLECULAR CELL

Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling

(2011) Marina Shkreli et al.   NATURE MEDICINE

The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNA

(2011) Anaïs Poulet et al.   NUCLEIC ACIDS RESEARCH

Short Telomeres Compromise β-Cell Signaling and Survival

(2011) Nini Guo et al.   PLoS One

Nontelomeric splice variant of telomere repeat-binding factor 2 maintains neuronal traits by sequestering repressor element 1-silencing transcription factor

(2011) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maintenance of tumor initiating cells of defined genetic composition by nucleostemin

(2011) N. Okamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT6 is required for maintenance of telomere position effect in human cells

(2011) Ruth I. Tennen et al.   Nature Communications

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

(2010) Jing Ye et al.   CELL

Role of TRF2 in the assembly of telomeric chromatin

(2010) Roberta Benetti et al.   CELL CYCLE

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence

(2010) Kaori Fujita et al.   NATURE CELL BIOLOGY

Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression

(2010) Hsiangling Teo et al.   NATURE CELL BIOLOGY

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

(2010) Paula Martinez et al.   NATURE CELL BIOLOGY

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

(2010) Roderick J O'Sullivan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Protein Network Surrounding the Human Telomere Repeat Binding Factors TRF1, TRF2, and POT1

(2010) Richard J. Giannone et al.   PLoS One

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

FoxO3 Regulates Neural Stem Cell Homeostasis

(2009) Valérie M. Renault et al.   Cell Stem Cell

TRF2 promotes, remodels and protects telomeric Holliday junctions

(2009) Anaïs Poulet et al.   EMBO JOURNAL

Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF

(2009) Alexandre Ottaviani et al.   EMBO JOURNAL

Telomeric RNAs Mark Sex Chromosomes in Stem Cells

(2009) L.-F. Zhang et al.   GENETICS

The functional importance of telomere clustering: Global changes in gene expression result from SIR factor dispersion

(2009) A. Taddei et al.   GENOME RESEARCH

In VivoStoichiometry of Shelterin Components

(2009) Kaori K. Takai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs

(2009) Hyeung Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase

(2009) Sofia L. Vidal-Cardenas et al.   NUCLEIC ACIDS RESEARCH

Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations

(2009) S. Schoeftner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERCC1/XPF Protects Short Telomeres from Homologous Recombination in Arabidopsis thaliana

(2009) Jean-Baptiste Vannier et al.   PLoS Genetics

Reduced telomerase activity in human T lymphocytes exposed to cortisol

(2008) Jenny Choi et al.   BRAIN BEHAVIOR AND IMMUNITY

Nontelomeric TRF2-REST Interaction Modulates Neuronal Gene Silencing and Fate of Tumor and Stem Cells

(2008) Peisu Zhang et al.   CURRENT BIOLOGY

TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program

(2008) Jinkuk Choi et al.   PLoS Genetics

The Identification of Zebrafish Mutants Showing Alterations in Senescence-Associated Biomarkers

(2008) Shuji Kishi et al.   PLoS Genetics

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

(2007) Antero Salminen et al.   AGEING RESEARCH REVIEWS