Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells

Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering

(2016) Addison V. Wright et al.   CELL

Integrative Pathway Analysis of Metabolic Signature in Bladder Cancer: A Linkage to The Cancer Genome Atlas Project and Prediction of Survival

(2016) Friedrich-Carl von Rundstedt et al.   JOURNAL OF UROLOGY

Adaptation in CRISPR-Cas Systems

(2016) Samuel H. Sternberg et al.   MOLECULAR CELL

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

CRISPR–Cas adaptation: insights into the mechanism of action

(2016) Gil Amitai et al.   NATURE REVIEWS MICROBIOLOGY

The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation

(2015) Quanyuan He et al.   Cell Stem Cell

Human telomerase: biogenesis, trafficking, recruitment, and activation

(2015) Jens C. Schmidt et al.   GENES & DEVELOPMENT

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

Molecular basis of telomere dysfunction in human genetic diseases

(2015) Grzegorz Sarek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Control of telomerase action at human telomeres

(2015) Dirk Hockemeyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

(2015) E. H. Blackburn et al.   SCIENCE

Molecular basis of telomere dysfunction in human genetic diseases

(2015) Grzegorz Sarek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Control of telomerase action at human telomeres

(2015) Dirk Hockemeyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

(2014) Alec N. Sexton et al.   GENES & DEVELOPMENT

Telomere-Regulating Genes and the Telomere Interactome in Familial Cancers

(2014) Carla Daniela Robles-Espinoza et al.   MOLECULAR CANCER RESEARCH

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation

(2014) Shaheen Kabir et al.   Cell Reports

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

BBS mutations modify phenotypic expression of CEP290-related ciliopathies

(2013) Yan Zhang et al.   HUMAN MOLECULAR GENETICS

Inhibition of Telomerase Recruitment and Cancer Cell Death

(2013) Mai Nakashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A popular engagement at the ends

(2013) Neal F. Lue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis

(2013) Chatchawan Singhapol et al.   PLoS One

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression

(2013) Paula Martínez et al.   Cell Reports

RNA-programmed genome editing in human cells

(2013) Martin Jinek et al.   eLife

TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends

(2012) Franklin L. Zhong et al.   CELL

Mitochondrial Localization of Telomeric Protein TIN2 Links Telomere Regulation to Metabolic Control

(2012) Liuh-Yow Chen et al.   MOLECULAR CELL

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

(2012) Jayakrishnan Nandakumar et al.   NATURE

RNA-guided genetic silencing systems in bacteria and archaea

(2012) Blake Wiedenheft et al.   NATURE

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Global Identification of Modular Cullin-RING Ligase Substrates

(2011) Michael J. Emanuele et al.   CELL

Human telomeric proteins occupy selective interstitial sites

(2011) Dong Yang et al.   CELL RESEARCH

Telomere Protection by TPP1/POT1 Requires Tethering to TIN2

(2011) Kaori K. Takai et al.   MOLECULAR CELL

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA

(2011) Rachel Litman Flynn et al.   NATURE

TPP1 Is Required for TERT Recruitment, Telomere Elongation during Nuclear Reprogramming, and Normal Skin Development in Mice

(2010) Agueda M. Tejera et al.   DEVELOPMENTAL CELL

Pot1 and telomere maintenance

(2010) Peter Baumann et al.   FEBS LETTERS

Telomeres avoid end detection by severing the checkpoint signal transduction pathway

(2010) Tiago Carneiro et al.   NATURE

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

(2010) Paula Martinez et al.   NATURE CELL BIOLOGY

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease

(2010) Rachel E. Haurwitz et al.   SCIENCE

Telomere Protection by TPP1 Is Mediated by POT1a and POT1b

(2009) T. Kibe et al.   MOLECULAR AND CELLULAR BIOLOGY

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs

(2009) Hyeung Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Functional Dissection of Human and Mouse POT1 Proteins

(2008) W. Palm et al.   MOLECULAR AND CELLULAR BIOLOGY

Pot1b Deletion and Telomerase Haploinsufficiency in Mice Initiate an ATR-Dependent DNA Damage Response and Elicit Phenotypes Resembling Dyskeratosis Congenita

(2008) H. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct Functions of POT1 at Telomeres

(2008) K. S. Barrientos et al.   MOLECULAR AND CELLULAR BIOLOGY

A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins

(2008) Y. Chen et al.   SCIENCE

The telosome/shelterin complex and its functions

(2008) Huawei Xin et al.   GENOME BIOLOGY