Fasting‐ and ghrelin‐induced food intake is regulated by NAMPT in the hypothalamus

ROS as Regulators of Mitochondrial Dynamics in Neurons

(2018) Carolina Cid-Castro et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

NAMPT-mediated NAD + biosynthesis is indispensable for adipose tissue plasticity and development of obesity

(2018) Karen Nørgaard Nielsen et al.   Molecular Metabolism

Hypothalamic Mitochondrial Dysfunction as a Target in Obesity and Metabolic Disease

(2018) Juan Cunarro et al.   Frontiers in Endocrinology

Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic connexin 43

(2018) Eun Roh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Blaming the Brain for Obesity: Integration of Hedonic and Homeostatic Mechanisms

(2017) Hans-Rudolf Berthoud et al.   GASTROENTEROLOGY

The Relevance of AgRP Neuron-Derived GABA Inputs to POMC Neurons Differs for Spontaneous and Evoked Release

(2017) Andrew R. Rau et al.   JOURNAL OF NEUROSCIENCE

NAMPT inhibitor protects ischemic neuronal injury in rat brain via anti-neuroinflammation

(2017) Chen-Xiang Chen et al.   NEUROSCIENCE

Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase

(2017) Li Q Zhang et al.   Cell Death & Disease

Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death

(2017) Xiaowan Wang et al.   Cell Reports

IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans -Signaling

(2017) Katharina Timper et al.   Cell Reports

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

(2016) David W. Frederick et al.   Cell Metabolism

Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery

(2016) Cecilia Ratner et al.   ENDOCRINOLOGY

Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration

(2016) Sarmistha Mukherjee et al.   HEPATOLOGY

Pre-B-cell colony-enhancing factor as a target for protecting against apoptotic neuronal death and mitochondrial damage in ischemia

(2016) Shinghua Ding et al.   Neural Regeneration Research

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

(2016) Samuel A. J. Trammell et al.   Nature Communications

NAMPT-Mediated NAD + Biosynthesis Is Essential for Vision In Mice

(2016) Jonathan B. Lin et al.   Cell Reports

NAMPT-Mediated NAD + Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice

(2016) Kelly L. Stromsdorfer et al.   Cell Reports

FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes

(2015) Alejandra P. Oyarzún et al.   BIOCHEMICAL PHARMACOLOGY

Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding

(2015) Michael J. Waterson et al.   Cell Metabolism

Central Sirt1 Regulates Body Weight and Energy Expenditure Along With the POMC-Derived Peptide α-MSH and the Processing Enzyme CPE Production in Diet-Induced Obese Male Rats

(2015) Nicole E. Cyr et al.   ENDOCRINOLOGY

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

Pleasure Systems in the Brain

(2015) Kent C. Berridge et al.   NEURON

NAMPT inhibitor and metabolite protect mouse brain from cryoinjury through distinct mechanisms

(2015) X.-Q. Zhang et al.   NEUROSCIENCE

NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone

(2015) Z Moore et al.   Cell Death & Disease

Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction

(2015) Antonio Zorzano et al.   Frontiers in Aging Neuroscience

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

(2015) Rafael Mayoral et al.   Molecular Metabolism

Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity

(2015) Tsutomu Sasaki   Frontiers in Endocrinology

On-Target Effect of FK866, a Nicotinamide Phosphoribosyl Transferase Inhibitor, by Apoptosis-Mediated Death in Chronic Lymphocytic Leukemia Cells

(2014) I. Gehrke et al.   CLINICAL CANCER RESEARCH

Cerebral Ischemia Is Exacerbated by Extracellular Nicotinamide Phosphoribosyltransferase via a Non-Enzymatic Mechanism

(2014) Bing Zhao et al.   PLoS One

Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors

(2013) C. C. S. Chini et al.   CLINICAL CANCER RESEARCH

Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice

(2013) Tsutomu Sasaki et al.   DIABETOLOGIA

Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues

(2013) Min Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle

(2013) Josef Brandauer et al.   JOURNAL OF PHYSIOLOGY-LONDON

TARGETED, LCMS-BASED METABOLOMICS FOR QUANTITATIVE MEASUREMENT OF NAD + METABOLITES

(2013) Samuel AJ Trammell et al.   Computational and Structural Biotechnology Journal

Oxidative Stress in the Hypothalamus: the Importance of Calcium Signaling and Mitochondrial ROS in Body Weight Regulation

(2012) Erika Gyengesi et al.   Current Neuropharmacology

Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity by Small Molecule GMX1778 Regulates Reactive Oxygen Species (ROS)-mediated Cytotoxicity in a p53- and Nicotinic Acid Phosphoribosyltransferase1 (NAPRT1)-dependent Manner

(2012) David Cerna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin

(2012) Luís Martins et al.   PLoS One

Arcuate AgRP neurons and the regulation of energy balance

(2012) Céline Cansell et al.   Frontiers in Endocrinology

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Setting the Tone: Reactive Oxygen Species and the Control of Appetitive Melanocortin Neurons

(2011) Justin J. Rochford et al.   Cell Metabolism

The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin

(2011) D. A. Velasquez et al.   DIABETES

Cellular Leptin Resistance Impairs the Leptin-Mediated Suppression of Neuropeptide Y Secretion in Hypothalamic Neurons

(2011) Sandeep S. Dhillon et al.   ENDOCRINOLOGY

Pre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models

(2011) Jing Bi et al.   JOURNAL OF NEUROCHEMISTRY

Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

(2011) Sabrina Diano et al.   NATURE MEDICINE

Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol

(2010) Stefanie Dietmair et al.   ANALYTICAL BIOCHEMISTRY

SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

(2010) Giorgio Ramadori et al.   Cell Metabolism

Inhibition of Nicotinamide Phosphoribosyltransferase

(2010) Maria Pittelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Protective Role of PBEF in a Mouse Model of Cerebral Ischemia

(2010) Weiping Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

(2010) M. O. Dietrich et al.   JOURNAL OF NEUROSCIENCE

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo

(2009) Laura Formentini et al.   BIOCHEMICAL PHARMACOLOGY

Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis

(2009) Jee-Young Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Female Urine Sniffing Test: A Novel Approach for Assessing Reward-Seeking Behavior in Rodents

(2009) Oz Malkesman et al.   BIOLOGICAL PSYCHIATRY

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Erratum: UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2009) Zane B. Andrews et al.   NATURE

Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System

(2009) Işin Çakir et al.   PLoS One

Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability

(2008) G. Ramadori et al.   JOURNAL OF NEUROSCIENCE