NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone

Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1-Deficient Tumor Models

(2015) Thomas O'Brien et al.   NEOPLASIA

Tumor-Selective, Futile Redox Cycle-Induced Bystander Effects Elicited by NQO1 Bioactivatable Radiosensitizing Drugs in Triple-Negative Breast Cancers

(2014) Lifen Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Synergy between the NAMPT Inhibitor GMX1777(8) and Pemetrexed in Non-Small Cell Lung Cancer Cells Is Mediated by PARP Activation and Enhanced NAD Consumption

(2014) M. Chan et al.   CANCER RESEARCH

253 Phase 1 correlative study of ARQ761, a β-lapachone analogue that promotes NQ01-mediated programmed cancer cell necrosis

(2014) D. Gerber et al.   EUROPEAN JOURNAL OF CANCER

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

(2014) S. A. Andrabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PARP-1 Hyperactivation and Reciprocal Elevations in Intracellular Ca2+ During ROS-Induced Nonapoptotic Cell Death

(2014) Fengjiao Zhang et al.   TOXICOLOGICAL SCIENCES

β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells

(2014) E J Park et al.   Cell Death & Disease

Nicotinamide preferentially protects glycolysis in dermal fibroblasts under oxidative stress conditions

(2013) H.A. Rovito et al.   BRITISH JOURNAL OF DERMATOLOGY

Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors

(2013) C. C. S. Chini et al.   CLINICAL CANCER RESEARCH

Poly(ADP-ribose) signaling in cell death

(2013) László Virág et al.   MOLECULAR ASPECTS OF MEDICINE

Catalase Abrogates  -Lapachone-Induced PARP1 Hyperactivation-Directed Programmed Necrosis in NQO1-Positive Breast Cancers

(2013) E. A. Bey et al.   MOLECULAR CANCER THERAPEUTICS

[18F]FLT and [18F]FDG PET for Non-invasive Treatment Monitoring of the Nicotinamide Phosphoribosyltransferase Inhibitor APO866 in Human Xenografts

(2013) Mette Munk Jensen et al.   PLoS One

An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

(2012) X. Huang et al.   CANCER RESEARCH

Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+Biosynthesis, in Human Cancer Cells

(2012) Bo Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas

(2011) UFFE HØGH OLESEN et al.   APMIS

Modulating Endogenous NQO1 Levels Identifies Key Regulatory Mechanisms of Action of  -Lapachone for Pancreatic Cancer Therapy

(2011) L. S. Li et al.   CLINICAL CANCER RESEARCH

β-Lapachone Significantly Increases the Effect of Ionizing Radiation to Cause Mitochondrial Apoptosis via JNK Activation in Cancer Cells

(2011) Moon-Taek Park et al.   PLoS One

Prostate Cancer Radiosensitization through Poly(ADP-Ribose) Polymerase-1 Hyperactivation

(2010) Y. Dong et al.   CANCER RESEARCH

Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions

(2009) Na Rae Hwang et al.   BIOCHEMICAL JOURNAL

The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies

(2009) A. Nahimana et al.   BLOOD

Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

(2009) Anne von Heideman et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Parthanatos, a messenger of death

(2009) Karen Kate David   Frontiers in Bioscience-Landmark

The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors

(2009) M. Watson et al.   MOLECULAR AND CELLULAR BIOLOGY

Development and validation of a liquid chromatography–tandem mass spectrometry method for the determination of ARQ 501 (β-lapachone) in plasma and tumors from nu/nu mouse xenografts

(2008) R.E. Savage et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES