Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy

Role of tau N-terminal motif in the secretion of human tau by End Binding proteins

(2019) C. Laura Sayas et al.   PLoS One

Tau exhibits unique seeding properties in globular glial tauopathy

(2019) Dah-eun Chloe Chung et al.   Acta Neuropathologica Communications

A cortical microvascular structure in vascular dementia, Alzheimer's disease, frontotemporal lobar degeneration and nondemented controls: a sign of angiogenesis due to brain ischaemia?

(2019) H. Ek Olofsson et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Involvement of Oligodendrocytes in Tau Seeding and Spreading in Tauopathies

(2019) Isidro Ferrer et al.   Frontiers in Aging Neuroscience

Cellular and regional vulnerability in frontotemporal tauopathies

(2019) Shelley L. Forrest et al.   ACTA NEUROPATHOLOGICA

Propagation of Protein Aggregation in Neurodegenerative Diseases

(2019) Jaime Vaquer-Alicea et al.   Annual Review of Biochemistry

Globular glial tauopathy caused by MAPT P301T mutation: clinical and neuropathological findings

(2019) M. E. Erro et al.   JOURNAL OF NEUROLOGY

The olfactory bulb proteotype differs across frontotemporal dementia spectrum

(2019) Mercedes Lachén-Montes et al.   Journal of Proteomics

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

(2019) Frank Koopmans et al.   NEURON

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Relevance of host tau in tau seeding and spreading in tauopathies

(2019) Isidro Ferrer et al.   BRAIN PATHOLOGY

Morphological characterisation of glial and neuronal tau pathology in globular glial tauopathy (Types II and III)

(2019) H. Tanaka et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Aging-related tau astrogliopathy (ARTAG): not only tau phosphorylation in astrocytes

(2018) Isidro Ferrer et al.   BRAIN PATHOLOGY

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

(2018) Francesc Guix et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene Expression Profile in Frontal Cortex in Sporadic Frontotemporal Lobar Degeneration-TDP

(2018) Pol Andrés-Benito et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Exosome-associated tau exacerbates brain functional impairments induced by traumatic brain injury in mice

(2018) Bo Wang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Altered expression of glutamate transporter-1 and water channel protein aquaporin-4 in human temporal cortex with Alzheimer's disease

(2018) A. Hoshi et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The multi-dimensional roles of astrocytes in ALS

(2018) Koji Yamanaka et al.   NEUROSCIENCE RESEARCH

Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies

(2018) Paula Garcia-Esparcia et al.   Frontiers in Aging Neuroscience

Phosphoproteomics of Alzheimer disease brain: Insights into altered brain protein regulation of critical neuronal functions and their contributions to subsequent cognitive loss

(2018) D. Allan Butterfield   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Endogenous Tau Aggregates in Oligodendrocytes of rTg4510 Mice Induced by Human P301L Tau

(2018) Yan Ren et al.   JOURNAL OF ALZHEIMERS DISEASE

Unveiling the olfactory proteostatic disarrangement in Parkinson’s disease by proteome-wide profiling

(2018) Mercedes Lachén-Montes et al.   NEUROBIOLOGY OF AGING

Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner

(2018) Isidro Ferrer   PROGRESS IN NEUROBIOLOGY

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The BioGRID interaction database: 2019 update

(2018) Rose Oughtred et al.   NUCLEIC ACIDS RESEARCH

Different tau species lead to heterogeneous tau pathology propagation and misfolding

(2018) Simon Dujardin et al.   Acta Neuropathologica Communications

Extracellular Vesicle Biology in Alzheimer’s Disease and Related Tauopathy

(2017) Annina M. DeLeo et al.   Journal of Neuroimmune Pharmacology

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

Understanding Alzheimer's disease by global quantification of protein phosphorylation and sialylated N-linked glycosylation profiles: A chance for new biomarkers in neuroproteomics?

(2017) Pernille S. Lassen et al.   Journal of Proteomics

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Clinicopathologic heterogeneity in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) due to microtubule-associated protein tau (MAPT) p.P301L mutation, including a patient with globular glial tauopathy

(2017) P. Tacik et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Connexin-43 and aquaporin-4 are markers of ageing-related tau astrogliopathy (ARTAG)-related astroglial response

(2017) G. G. Kovacs et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Propagation of Tau aggregates

(2017) Michel Goedert et al.   Molecular Brain

Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer’s disease progression

(2017) Mercedes Lachén-Montes et al.   Scientific Reports

High–Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo

(2016) Emilie Audouard et al.   AMERICAN JOURNAL OF PATHOLOGY

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

(2016) Lana M. Osborn et al.   PROGRESS IN NEUROBIOLOGY

Animal modeling an oligodendrogliopathy – multiple system atrophy

(2016) Jonathan M. Bleasel et al.   Acta Neuropathologica Communications

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

(2016) Meryem Tardivel et al.   Acta Neuropathologica Communications

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

(2015) Sayuri Taniguchi-Watanabe et al.   ACTA NEUROPATHOLOGICA

A novel tau mutation, p.K317N, causes globular glial tauopathy

(2015) Pawel Tacik et al.   ACTA NEUROPATHOLOGICA

Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

(2015) Jada Lewis et al.   ACTA NEUROPATHOLOGICA

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice

(2015) Ilie-Cosmin Stancu et al.   ACTA NEUROPATHOLOGICA

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

(2015) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome

(2015) Karina Hernández-Ortega et al.   BRAIN PATHOLOGY

Contributions of the Prion Protein Sequence, Strain, and Environment to the Species Barrier

(2015) Aditi Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Familial Behavioral Variant Frontotemporal Dementia Associated With Astrocyte-Predominant Tauopathy

(2015) Isidre Ferrer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroinflammatory Gene Regulation, Mitochondrial Function, Oxidative Stress, and Brain Lipid Modifications With Disease Progression in Tau P301S Transgenic Mice as a Model of Frontotemporal Lobar Degeneration-Tau

(2015) Irene López-González et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?

(2015) Benjamin Ettle et al.   MOLECULAR NEUROBIOLOGY

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Invited review: Frontotemporal dementia caused bymicrotubule-associated protein taugene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

(2015) Bernardino Ghetti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Invited review: Prion-like transmission and spreading of tau pathology

(2015) Florence Clavaguera et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The established and emerging roles of astrocytes and microglia in amyotrophic lateral sclerosis and frontotemporal dementia

(2015) Rowan A. Radford et al.   Frontiers in Cellular Neuroscience

Olfactory bulb proteome dynamics during the progression of sporadic Alzheimer’s disease: identification of common and distinct olfactory targets across Alzheimer-related co-pathologies

(2015) María Victoria Zelaya et al.   Oncotarget

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains

(2014) Susana Boluda et al.   ACTA NEUROPATHOLOGICA

Glia in the pathogenesis of neurodegenerative diseases

(2014) Alexei Verkhratsky et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain

(2014) Kazuhiko Tagawa et al.   HUMAN MOLECULAR GENETICS

Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model

(2014) Yiwen Cui et al.   Journal of Neuroinflammation

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

In silico prediction of physical protein interactions and characterization of interactome orphans

(2014) Max Kotlyar et al.   NATURE METHODS

αB-crystallin and HSP27 in glial cells in tauopathies

(2014) Irene López-González et al.   NEUROPATHOLOGY

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein

(2014) Simon Dujardin et al.   PLoS One

Refined phosphopeptide enrichment by phosphate additive and the analysis of human brain phosphoproteome

(2014) Haiyan Tan et al.   PROTEOMICS

Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins

(2014) Eric B. Dammer et al.   PROTEOMICS

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

(2014) Simon Dujardin et al.   Acta Neuropathologica Communications

Globular glial tauopathies (GGT): consensus recommendations

(2013) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Species-barrier phenomenon in prion transmissibility from a viewpoint of protein science

(2013) K. Hagiwara et al.   JOURNAL OF BIOCHEMISTRY

A Rapid Gene Delivery-Based Mouse Model for Early-Stage Alzheimer Disease-Type Tauopathy

(2013) Robert Siman et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Glial and Neuronal Tau Pathology in Tauopathies

(2013) Isidre Ferrer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Profiling Murine Tau with 0N, 1N and 2N Isoform-Specific Antibodies in Brain and Peripheral Organs Reveals Distinct Subcellular Localization, with the 1N Isoform Being Enriched in the Nucleus

(2013) Chang Liu et al.   PLoS One

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoproteome profiling of substantia nigra and cortex regions of Alzheimer’s disease patients

(2012) Saadia Zahid et al.   JOURNAL OF NEUROCHEMISTRY

Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription

(2012) Rong Cong et al.   NUCLEIC ACIDS RESEARCH

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia

(2012) Isidro Ferrer   PROGRESS IN NEUROBIOLOGY

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies

(2011) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts

(2011) Lisa Fellner et al.   ACTA NEUROPATHOLOGICA

In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

(2011) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects

(2011) Fabio Di Domenico et al.   Journal of Proteomics

Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, Parkinsonism, and motor neuron disease: a distinct clinicopathological and biochemical disease entity

(2010) Yong-Juan Fu et al.   ACTA NEUROPATHOLOGICA

Astroglial networks: a step further in neuroglial and gliovascular interactions

(2010) Christian Giaume et al.   NATURE REVIEWS NEUROSCIENCE

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice

(2010) X. Mei et al.   NEUROSCIENCE

Characteristics and consequences of muscarinic receptor activation by tau protein

(2009) Alberto Gómez-Ramos et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Multiple system atrophy: A primary oligodendrogliopathy

(2008) Gregor K. Wenning et al.   ANNALS OF NEUROLOGY

Tau isoform regulation is region- and cell-specific in mouse brain

(2008) Pamela McMillan et al.   JOURNAL OF COMPARATIVE NEUROLOGY

White Matter Tauopathy With Globular Glial Inclusions: A Distinct Sporadic Frontotemporal Lobar Degeneration

(2008) Gabor G. Kovacs et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

(2008) J.E. Simpson et al.   NEUROBIOLOGY OF AGING