Cellular and regional vulnerability in frontotemporal tauopathies

Astrocyte function from information processing to cognition and cognitive impairment

(2019) Mirko Santello et al.   NATURE NEUROSCIENCE

A walk through tau therapeutic strategies

(2019) Santosh Jadhav et al.   Acta Neuropathologica Communications

Association of MAPT Subhaplotypes With Risk of Progressive Supranuclear Palsy and Severity of Tau Pathology

(2019) Michael G. Heckman et al.   JAMA Neurology

Sensitivity and Specificity of Diagnostic Criteria for Progressive Supranuclear Palsy

(2019) Farwa Ali et al.   MOVEMENT DISORDERS

Functional connectivity associated with tau levels in ageing, Alzheimer’s, and small vessel disease

(2019) Nicolai Franzmeier et al.   BRAIN

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

(2018) Sarah K. Kaufman et al.   ACTA NEUROPATHOLOGICA

Preclinical, phase I, and phase II investigational clinical trials for treatment of progressive supranuclear palsy

(2018) Ali Shoeibi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Argyrophilic Grain Pathology in Frontotemporal Lobar Degeneration: Demographic, Clinical, Neuropathological, and Genetic Features

(2018) María José Gil et al.   JOURNAL OF ALZHEIMERS DISEASE

How the shapes of seeds can influence pathology

(2018) Ronald Melki   NEUROBIOLOGY OF DISEASE

Dendritic Tau in Alzheimer’s Disease

(2018) Arne Ittner et al.   NEURON

Familial tauopathy with P364S MAPT mutation: clinical course, neuropathology and ultrastructure of neuronal tau inclusions

(2018) P. Štrafela et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

(2018) Stephen D. Skaper et al.   Frontiers in Cellular Neuroscience

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

(2018) Iris Broce et al.   PLOS MEDICINE

CXCR4 involvement in neurodegenerative diseases

(2018) Luke W. Bonham et al.   Translational Psychiatry

Presymptomatic white matter integrity loss in familial frontotemporal dementia in the GENFI cohort: A cross-sectional diffusion tensor imaging study

(2018) Lize C. Jiskoot et al.   Annals of Clinical and Translational Neurology

Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain

(2018) Gabor G. Kovacs et al.   Acta Neuropathologica Communications

Different patterns of hippocampal tau pathology in Alzheimer’s disease and PART

(2018) Kurt A. Jellinger   ACTA NEUROPATHOLOGICA

Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy

(2018) Mariet Allen et al.   ACTA NEUROPATHOLOGICA

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Selective vulnerability in neurodegenerative diseases

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review

(2018) Maxime Montembeault et al.   Frontiers in Neurology

Argyrophilic grain disease presenting as behavioral frontotemporal dementia

(2018) María José Gil et al.   CLINICAL NEUROPATHOLOGY

Frontotemporal lobar degeneration: Study of a clinicopathological cohort

(2018) María José Gil et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Review: Fluid biomarkers for frontotemporal dementias

(2018) H. Zetterberg et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Diversity and Specificity of Astrocyte–neuron Communication

(2018) Caitlin A. Durkee et al.   NEUROSCIENCE

Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference

(2018) Alexandra L Young et al.   Nature Communications

Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials

(2018) Adam M Staffaroni et al.   BRAIN

Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons

(2017) Roberto Piacentini et al.   GLIA

YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies

(2017) Marta Querol-Vilaseca et al.   Journal of Neuroinflammation

Corticobasal degeneration: key emerging issues

(2017) F. Ali et al.   JOURNAL OF NEUROLOGY

Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases

(2017) Gabor G. Kovacs et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria

(2017) Günter U. Höglinger et al.   MOVEMENT DISORDERS

Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?

(2017) Jennifer L. Whitwell et al.   MOVEMENT DISORDERS

Imaging and fluid biomarkers in frontotemporal dementia

(2017) Lieke H. Meeter et al.   Nature Reviews Neurology

CSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration

(2017) Daniel Alcolea et al.   NEUROLOGY

Clinicopathologic heterogeneity in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) due to microtubule-associated protein tau (MAPT) p.P301L mutation, including a patient with globular glial tauopathy

(2017) P. Tacik et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Astrocytes locally translate transcripts in their peripheral processes

(2017) Kristina Sakers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

Meta-analysis of the association between variants in MAPT and neurodegenerative diseases

(2017) Cheng-Cheng Zhang et al.   Oncotarget

Widespread tau seeding activity at early Braak stages

(2016) Jennifer L. Furman et al.   ACTA NEUROPATHOLOGICA

Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci

(2016) Mariet Allen et al.   ACTA NEUROPATHOLOGICA

Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology

(2016) Helen Ling et al.   BRAIN

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology inMAPTmutation carriers

(2016) Ruben Smith et al.   BRAIN

Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study

(2016) Roberta Diehl Rodriguez et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration

(2016) Dominic M. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Incidental corticobasal degeneration

(2016) A. Martínez-Maldonado et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Classification of the primary progressive aphasias: principles and review of progress since 2011

(2016) Rik Vandenberghe   Alzheimers Research & Therapy

Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration

(2016) Kamalini G. Ranasinghe et al.   JAMA Neurology

Neuropathologic Associations of Learning and Memory in Primary Progressive Aphasia

(2016) Stephanie Kielb et al.   JAMA Neurology

Characterization of Movement Disorder Phenomenology in Genetically Proven, Familial Frontotemporal Lobar Degeneration: A Systematic Review and Meta-Analysis

(2016) Carmen Gasca-Salas et al.   PLoS One

Does the difference between PART and Alzheimer’s disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau?

(2015) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

A novel tau mutation, p.K317N, causes globular glial tauopathy

(2015) Pawel Tacik et al.   ACTA NEUROPATHOLOGICA

PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

(2015) Kurt A. Jellinger et al.   ACTA NEUROPATHOLOGICA

PART is part of Alzheimer disease

(2015) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

(2015) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

Antisense oligonucleotides in therapy for neurodegenerative disorders

(2015) Melvin M. Evers et al.   ADVANCED DRUG DELIVERY REVIEWS

Deep clinical and neuropathological phenotyping of Pick disease

(2015) David J. Irwin et al.   ANNALS OF NEUROLOGY

The Role of Neuroinflammation in Dementias

(2015) Giuseppe Pasqualetti et al.   Current Neurology and Neuroscience Reports

Frontotemporal lobar degeneration FTLD-tau: preclinical lesions, vascular, and Alzheimer-related co-pathologies

(2015) Dietmar Rudolf Thal et al.   JOURNAL OF NEURAL TRANSMISSION

Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis

(2015) Jonathan D Rohrer et al.   LANCET NEUROLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Could astrocytes be the primary target of an offending agent causing the primary degenerative diseases of the human central nervous system? A hypothesis

(2015) Roberto E. Sica   MEDICAL HYPOTHESES

The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome

(2015) C. Geeth Gunawardana et al.   MOLECULAR & CELLULAR PROTEOMICS

Slowly progressive behavioural presentation in two UK cases with the R406W MAPT mutation

(2015) R. Wood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Review: An update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations

(2015) Tammaryn Lashley et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Invited review: Frontotemporal dementia caused bymicrotubule-associated protein taugene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

(2015) Bernardino Ghetti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Three sib-pairs of autopsy-confirmed progressive supranuclear palsy

(2015) Shinsuke Fujioka et al.   PARKINSONISM & RELATED DISORDERS

Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy

(2015) Naomi Kouri et al.   Nature Communications

Early Stage of Progressive Supranuclear Palsy: A Neuropathological Study of 324 Consecutive Autopsy Cases

(2015) Akane Nogami et al.   JOURNAL OF NIPPON MEDICAL SCHOOL

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

A disease-specific metabolic brain network associated with corticobasal degeneration

(2014) Martin Niethammer et al.   BRAIN

FDG-PET in pathologically confirmed spontaneous 4R-tauopathy variants

(2014) Nicholas Zalewski et al.   JOURNAL OF NEUROLOGY

New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications

(2014) L. Chare et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cognition in corticobasal syndrome and progressive supranuclear palsy: A review

(2014) James R. Burrell et al.   MOVEMENT DISORDERS

The phenotypic spectrum of progressive supranuclear palsy: A retrospective multicenter study of 100 definite cases

(2014) Gesine Respondek et al.   MOVEMENT DISORDERS

Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy

(2014) Raffaele Ferrari et al.   NEUROBIOLOGY OF AGING

Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias

(2014) Melissa E Murray et al.   Alzheimers Research & Therapy

Antisense-mediated Exon Skipping Decreases Tau Protein Expression: A Potential Therapy For Tauopathies

(2014) Reeteka Sud et al.   Molecular Therapy-Nucleic Acids

Neuropathological characterization of two siblings carrying the MAPT S305S mutation demonstrates features resembling argyrophilic grain disease

(2013) Annica Rönnbäck et al.   ACTA NEUROPATHOLOGICA

Corticobasal degeneration with olivopontocerebellar atrophy and TDP-43 pathology: an unusual clinicopathologic variant of CBD

(2013) Naomi Kouri et al.   ACTA NEUROPATHOLOGICA

Globular glial tauopathies (GGT): consensus recommendations

(2013) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases

(2013) Steven E. Arnold et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Glial and Neuronal Tau Pathology in Tauopathies

(2013) Isidre Ferrer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Cervical spine manifestations in patients with inflammatory arthritides

(2013) Thomas D. Cha et al.   Nature Reviews Rheumatology

Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration

(2013) Corey T. McMillan et al.   NEUROBIOLOGY OF AGING

Criteria for the diagnosis of corticobasal degeneration

(2013) M. J. Armstrong et al.   NEUROLOGY

Characteristics of progressive supranuclear palsy presenting with corticobasal syndrome: a cortical variant

(2013) H. Ling et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Development and Validation of Pedigree Classification Criteria for Frontotemporal Lobar Degeneration

(2013) Elisabeth M. Wood et al.   JAMA Neurology

The MAPT H1 haplotype is associated with tangle-predominant dementia

(2012) Ismael Santa-Maria et al.   ACTA NEUROPATHOLOGICA

FTDP-17 Tau Mutations Induce Distinct Effects on Aggregation and Microtubule Interactions

(2012) Benjamin Combs et al.   BIOCHEMISTRY

Upcoming candidate cerebrospinal fluid biomarkers of Alzheimer’s disease

(2012) Anne M Fagan et al.   Biomarkers in Medicine

Incidental corticobasal degeneration in a 76-year-old woman

(2012) Ivan Milenkovic et al.   CLINICAL NEUROPATHOLOGY

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

(2012) Daniah Trabzuni et al.   HUMAN MOLECULAR GENETICS

Neuroimaging in frontotemporal lobar degeneration—predicting molecular pathology

(2012) Jennifer L. Whitwell et al.   Nature Reviews Neurology

Neuropathology of the hippocampus in FTLD-Tau with Pick bodies: a study of the BrainNet Europe Consortium

(2012) G. G. Kovacs et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Globular glial tauopathies (GGT) presenting with motor neuron disease or frontotemporal dementia: an emerging group of 4-repeat tauopathies

(2011) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Neuropathological background of phenotypical variability in frontotemporal dementia

(2011) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration

(2011) J. D. Rohrer et al.   BRAIN

Current concepts of neuropathological diagnostics in practice: neurodegenerative diseases

(2011) G.G. Kovacs et al.   CLINICAL NEUROPATHOLOGY

The frontotemporal dementia mutation R406W blocks tau’s interaction with the membrane in an annexin A2–dependent manner

(2011) Anne Gauthier-Kemper et al.   JOURNAL OF CELL BIOLOGY

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

(2011) Dennis W. Dickson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Blocking epidermal growth factor receptor attenuates reactive astrogliosis through inhibiting cell cycle progression and protects against ischemic brain injury in rats

(2011) Qin Yang et al.   JOURNAL OF NEUROCHEMISTRY

Diagnostic criteria for corticobasal syndrome: a comparative study

(2011) Robert Mathew et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

(2011) Günter U Höglinger et al.   NATURE GENETICS

Clinical phenotypes in autopsy-confirmed Pick disease

(2011) O. Piguet et al.   NEUROLOGY

Specific Detection of Pathological Three-repeat Tau after Pretreatment with Potassium Permanganate and Oxalic Acid in PSP/CBD Brains

(2010) Toshiki Uchihara et al.   BRAIN PATHOLOGY

Neuropathology of variants of progressive supranuclear palsy

(2010) Dennis W Dickson et al.   CURRENT OPINION IN NEUROLOGY

Clinicopathological characterization of Pick’s disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions

(2009) Osamu Yokota et al.   ACTA NEUROPATHOLOGICA

Semantic dementia: demography, familial factors and survival in a consecutive series of 100 cases

(2009) J. R. Hodges et al.   BRAIN

Prediction of pathology in primary progressive language and speech disorders

(2009) V. Deramecourt et al.   NEUROLOGY

Argyrophilic grain disease

(2008) I. Ferrer et al.   BRAIN

Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus

(2007) Tara M. Caffrey et al.   NEUROBIOLOGY OF AGING

Argyrophilic grains: A distinct disease or an additive pathology?

(2007) Keith A. Josephs et al.   NEUROBIOLOGY OF AGING