Cellular mechanisms underlying steroid-resistant asthma

Pulmonary group 2 innate lymphoid cells: surprises and challenges

(2019) Malcolm R. Starkey et al.   Mucosal Immunology

Severe asthma in children—a review of definitions, epidemiology, and treatment options in 2019

(2019) Husam Ahmed et al.   PEDIATRIC PULMONOLOGY

Severe Asthma in Childhood

(2019) Angela Marko et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Saturated fatty acids, obesity, and the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome in asthmatic patients

(2018) Lisa G. Wood et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

After asthma: redefining airways diseases

(2018) Ian D Pavord et al.   LANCET

Short-chain fatty acids increase TNFα-induced inflammation in primary human lung mesenchymal cells through the activation of p38 MAPK

(2018) Sandra Rutting et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Modeling TH 2 responses and airway inflammation to understand fundamental mechanisms regulating the pathogenesis of asthma

(2017) Paul S. Foster et al.   IMMUNOLOGICAL REVIEWS

Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma

(2017) Philip M. Hansbro et al.   IMMUNOLOGICAL REVIEWS

MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase–mediated suppression of histone deacetylase 2

(2017) Richard Y. Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c

(2017) Gang Liu et al.   JOURNAL OF PATHOLOGY

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial

(2017) Peter G Gibson et al.   LANCET

Inflammasomes in the lung

(2017) James W. Pinkerton et al.   MOLECULAR IMMUNOLOGY

Biologic Therapy and Novel Molecular Targets of Severe Asthma

(2017) Amber N. Pepper et al.   Journal of Allergy and Clinical Immunology-In Practice

STAT6 Regulates the Development of Eosinophilic versus Neutrophilic Asthma in Response toAlternaria alternata

(2016) Andrea C. Valladao et al.   JOURNAL OF IMMUNOLOGY

Targeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease

(2015) Alan Chen-Yu Hsu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Nucleotide-Binding Domain, Leucine-Rich Repeat Protein 3 Inflammasome/IL-1 Receptor I Axis Mediates Innate, but Not Adaptive, Immune Responses after Exposure to Particulate Matter under 10 μm

(2015) Jeremy A. Hirota et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33

(2015) Christina A. Christianson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization

(2015) M J Gold et al.   Mucosal Immunology

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma

(2015) Ama-Tawiah Essilfie et al.   THORAX

Inflammasomes in COPD and neutrophilic asthma

(2015) Richard Y Kim et al.   THORAX

MicroRNA Expression Is Altered in an Ovalbumin-Induced Asthma Model and Targeting miR-155 with Antagomirs Reveals Cellular Specificity

(2015) Maximilian W. Plank et al.   PLoS One

Chlamydia muridarum Infection Subverts Dendritic Cell Function to Promote Th2 Immunity and Airways Hyperreactivity

(2014) G. E. Kaiko et al.   JOURNAL OF IMMUNOLOGY

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

(2014) Elisabeth H. Bel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation

(2014) J. Beale et al.   Science Translational Medicine

Activity and expression of histone acetylases and deacetylases in inflammatory phenotypes of asthma

(2013) L. P. Gunawardhana et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Airway epithelial regulation of pulmonary immune homeostasis and inflammation

(2013) Teal S. Hallstrand et al.   CLINICAL IMMUNOLOGY

Murine models of infectious exacerbations of airway inflammation

(2013) Malcolm Ronald Starkey et al.   CURRENT OPINION IN PHARMACOLOGY

Elevated expression of the NLRP3 inflammasome in neutrophilic asthma

(2013) J. L. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

The emerging role of microRNAs in regulating immune and inflammatory responses in the lung

(2013) Paul S. Foster et al.   IMMUNOLOGICAL REVIEWS

Abr, a Negative Regulator of Rac, Attenuates Cockroach Allergen-Induced Asthma in a Mouse Model

(2013) D. Gong et al.   JOURNAL OF IMMUNOLOGY

Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease

(2013) M R Starkey et al.   Mucosal Immunology

Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1β — A Possible Pathway of Exacerbations in COPD

(2013) Johannes Rotta detto Loria et al.   PLoS One

Evidence of Infectious Asthma Phenotype: Chlamydia-Induced Allergy and Pathogen-Specific IgE in a Neonatal Mouse Model

(2013) Katir K. Patel et al.   PLoS One

Th2 cytokine antagonists: potential treatments for severe asthma

(2012) Philip M Hansbro et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Components of Streptococcus pneumoniae Suppress Allergic Airways Disease and NKT Cells by Inducing Regulatory T Cells

(2012) A. N. Thorburn et al.   JOURNAL OF IMMUNOLOGY

Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease

(2012) M R Starkey et al.   Mucosal Immunology

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

TLR2/MyD88/NF-κB Pathway, Reactive Oxygen Species, Potassium Efflux Activates NLRP3/ASC Inflammasome during Respiratory Syncytial Virus Infection

(2012) Jesus Segovia et al.   PLoS One

Chlamydia pneumoniae-Specific IgE Is Prevalent in Asthma and Is Associated with Disease Severity

(2012) David L. Hahn et al.   PLoS One

CombinedHaemophilus influenzaerespiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma

(2012) Ama-Tawiah Essilfie et al.   THORAX

Cytokine/anti-cytokine therapy - novel treatments for asthma?

(2011) Philip M Hansbro et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples

(2011) Katherine J. Baines et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation

(2011) Sarah Haylock-Jacobs et al.   JOURNAL OF AUTOIMMUNITY

Biochemical Basis of Asthma Therapy

(2011) Peter J. Barnes   JOURNAL OF BIOLOGICAL CHEMISTRY

Haemophilus influenzae Infection Drives IL-17-Mediated Neutrophilic Allergic Airways Disease

(2011) Ama-Tawiah Essilfie et al.   PLoS Pathogens

Glucocorticosteroids: current and future directions

(2010) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Potential Therapeutic Targets for Steroid-Resistant Asthma

(2010) Wan Wang et al.   CURRENT DRUG TARGETS

Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia

(2010) Lisa G. Wood et al.   FREE RADICAL RESEARCH

Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology

(2010) Jay C. Horvat et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inflammation and Fibrosis during Chlamydia pneumoniae Infection Is Regulated by IL-1 and the NLRP3/ASC Inflammasome

(2010) X. He et al.   JOURNAL OF IMMUNOLOGY

Chlamydial Respiratory Infection during Allergen Sensitization Drives Neutrophilic Allergic Airways Disease

(2010) J. C. Horvat et al.   JOURNAL OF IMMUNOLOGY

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Infectious Chlamydia pneumoniae is Associated With Elevated Interleukin-8 and Airway Neutrophilia in Children With Refractory Asthma

(2010) Katir K. Patel et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Inhibition of PI3Kδ Restores Glucocorticoid Function in Smoking-induced Airway Inflammation in Mice

(2009) John A. Marwick et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Long-term macrolide therapy in chronic inflammatory airway diseases

(2009) P. A. J. Crosbie et al.   EUROPEAN RESPIRATORY JOURNAL

MicroRNA-21 Is Up-Regulated in Allergic Airway Inflammation and Regulates IL-12p35 Expression

(2009) T. X. Lu et al.   JOURNAL OF IMMUNOLOGY

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

Histone deacetylase-2 and airway disease

(2009) Peter J. Barnes   Therapeutic Advances in Respiratory Disease

Molecular Mechanisms of Corticosteroid Resistance

(2008) Ian M. Adcock et al.   CHEST

Steroid resistance in asthma: Mechanisms and treatment options

(2008) Ian M. Adcock et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Understanding the mechanisms of viral induced asthma: New therapeutic directions

(2008) Nicole G. Hansbro et al.   PHARMACOLOGY & THERAPEUTICS

Clarithromycin Targets Neutrophilic Airway Inflammation in Refractory Asthma

(2007) Jodie L. Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE