Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1β — A Possible Pathway of Exacerbations in COPD

Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent

(2014) E. Doz et al.   JOURNAL OF IMMUNOLOGY

Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia

(2013) Taylor S. Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

Ventilator-induced Lung Injury Is Mediated by the NLRP3 Inflammasome

(2012) Maria T. Kuipers et al.   ANESTHESIOLOGY

Cross-talk between Staphylococcus aureus leukocidins-intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome-dependent manner

(2012) Magali Perret et al.   CELLULAR MICROBIOLOGY

NLRC4 Inflammasome-Mediated Production of IL-1  Modulates Mucosal Immunity in the Lung against Gram-Negative Bacterial Infection

(2012) S. Cai et al.   JOURNAL OF IMMUNOLOGY

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

The role of inflammasome modulation in virulence

(2012) Christopher R. Lupfer et al.   Virulence

RAGE and tobacco smoke: insights into modeling chronic obstructive pulmonary disease

(2012) Adam B. Robinson et al.   Frontiers in Physiology

Innate Immunity in the Respiratory Epithelium

(2011) Dane Parker et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Glucocorticoids Sensitize the Innate Immune System through Regulation of the NLRP3 Inflammasome

(2011) John M. Busillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

(2011) Leif E. Sander et al.   NATURE

Caspase-1 Dependent IL-1β Secretion Is Critical for Host Defense in a Mouse Model of Chlamydia pneumoniae Lung Infection

(2011) Kenichi Shimada et al.   PLoS One

P2X7 Receptor and Caspase 1 Activation Are Central to Airway Inflammation Observed after Exposure to Tobacco Smoke

(2011) Suffwan Eltom et al.   PLoS One

Innate immunity in the human lung: pathogen recognition and lung disease

(2010) Kristina Rohmann et al.   CELL AND TISSUE RESEARCH

The Role of Potassium in Inflammasome Activation by Bacteria

(2010) Cecilia S. Lindestam Arlehamn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation and Fibrosis during Chlamydia pneumoniae Infection Is Regulated by IL-1 and the NLRP3/ASC Inflammasome

(2010) X. He et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes and autoimmunity

(2010) Patrick J. Shaw et al.   TRENDS IN MOLECULAR MEDICINE

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

(2010) Edel A. McNeela et al.   PLoS Pathogens

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

IL-1R1/MyD88 Signaling Is Critical for Elastase-Induced Lung Inflammation and Emphysema

(2009) I. Couillin et al.   JOURNAL OF IMMUNOLOGY

Involvement of the NLRP3 Inflammasome in Innate and Humoral Adaptive Immune Responses to Fungal  -Glucan

(2009) H. Kumar et al.   JOURNAL OF IMMUNOLOGY

Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF- B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor

(2009) J. Harder et al.   JOURNAL OF IMMUNOLOGY

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD