Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte–dendritic cell antigen presentation

The enigmatic role of the neutrophil in asthma: Friend, foe or indifferent?

(2018) R. J. Snelgrove et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance

(2018) Melissa A. Meyer et al.   Nature Communications

Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

(2018) Aran Singanayagam et al.   Nature Communications

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness

(2018) Dhiren F. Patel et al.   Science Translational Medicine

Anti-inflammatory role of CD11b+Ly6G+ neutrophilic cells in allergic airway inflammation in mice

(2018) Negar Nowroozilarki et al.   IMMUNOLOGY LETTERS

Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes

(2017) Alberto Yáñez et al.   IMMUNITY

Pulmonary ORMDL3 is critical for induction of Alternaria -induced allergic airways disease

(2017) Stephan Löser et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

(2017) Antonia Wallrapp et al.   NATURE

Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma

(2017) Henrik Watz et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial

(2016) Paul M O'Byrne et al.   Lancet Respiratory Medicine

Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo

(2016) Laura J. Hoodless et al.   Scientific Reports

Evolving Concepts of Asthma

(2015) Marc Gauthier et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions

(2015) Stipo Jurcevic et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Depletion of CD11c+cells in the CD11c.DTR model drives expansion of unique CD64+Ly6C+monocytes that are poised to release TNF-α

(2015) Shivajanani Sivakumaran et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

G-CSF and GM-CSF in Neutropenia

(2015) Hrishikesh M. Mehta et al.   JOURNAL OF IMMUNOLOGY

Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses

(2015) Timotheus Y F Halim et al.   NATURE IMMUNOLOGY

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets

(2015) Michelle L Robinette et al.   NATURE IMMUNOLOGY

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow

(2015) Andreas Schlitzer et al.   NATURE IMMUNOLOGY

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes

(2015) Anja Hasenberg et al.   NATURE METHODS

Analysis of a Panel of 48 Cytokines in BAL Fluids Specifically Identifies IL-8 Levels as the Only Cytokine that Distinguishes Controlled Asthma from Uncontrolled Asthma, and Correlates Inversely with FEV1

(2015) Koa Hosoki et al.   PLoS One

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

(2014) Christopher J. Oliphant et al.   IMMUNITY

IL-17A Inhibits the Expansion of IL-17A-Producing T Cells in Mice through "Short-Loop" Inhibition via IL-17 Receptor

(2014) E. Smith et al.   JOURNAL OF IMMUNOLOGY

High-dimensional analysis of the murine myeloid cell system

(2014) Burkhard Becher et al.   NATURE IMMUNOLOGY

Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma

(2014) W. Barchuk et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Randomized, Double-Blind, Placebo-controlled Study of Brodalumab, a Human Anti–IL-17 Receptor Monoclonal Antibody, in Moderate to Severe Asthma

(2013) William W. Busse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

(2013) Wendy C. Moore et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of a FLAP inhibitor, GSK2190915, in asthmatics with high sputum neutrophils

(2013) R. Chaudhuri et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling

(2012) S. Bugl et al.   BLOOD

Ly6G ligation blocks recruitment of neutrophils via a  2-integrin-dependent mechanism

(2012) J.-X. Wang et al.   BLOOD

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

(2012) P. Nair et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

(2012) Christopher D. Lucas et al.   FASEB JOURNAL

Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice

(2012) Junjie Mei et al.   JOURNAL OF CLINICAL INVESTIGATION

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

The efficacy and tolerability of MK-0633, a 5-lipoxygenase inhibitor, in chronic asthma

(2011) Yasmine S. Wasfi et al.   RESPIRATORY MEDICINE

Inflammatory Monocytes but Not Neutrophils Are Necessary To Control Infection with Toxoplasma gondii in Mice

(2010) I. R. Dunay et al.   INFECTION AND IMMUNITY

Serum Eosinophil Cationic Protein and 27 Cytokines/Chemokines in Acute Exacerbation of Childhood Asthma

(2010) Masahiko Kato et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease

(2010) Sarah Fox et al.   Journal of Innate Immunity

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Inhaled house dust mite induces pulmonary T helper 2 cytokine production

(2009) L. G. Gregory et al.   CLINICAL AND EXPERIMENTAL ALLERGY