Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

Determinants of initial inhaled corticosteroid use in patients with GOLD A/B COPD: a retrospective study of UK general practice

(2017) James D. Chalmers et al.   npj Primary Care Respiratory Medicine

Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin

(2016) Akihisa Mitani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation Enhances Susceptibility to Influenza Infection in Chronic Obstructive Pulmonary Disease Epithelium

(2016) Alan C.-Y. Hsu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Oxidative and Nitrosative Stress and Histone Deacetylase-2 Activity in Exacerbations of COPD

(2016) Joseph Footitt et al.   CHEST

Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line

(2016) Nikhil Nitin Kulkarni et al.   IMMUNOBIOLOGY

A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD

(2015) Aran Singanayagam et al.   CLINICAL SCIENCE

Cryptococcus neoformans Infection in Mice Lacking Type I Interferon Signaling Leads to Increased Fungal Clearance and IL-4-Dependent Mucin Production in the Lungs

(2015) Ko Sato et al.   PLoS One

The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections. A Randomized Trial

(2014) Ratko Djukanović et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma ExacerbationsIn Vivo

(2014) David J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation and activity of secretory leukoprotease inhibitor (SLPI) is altered in smokers

(2013) Megan Meyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Basic Research on Virus-Induced Asthma Exacerbation: Inhibition of Inflammatory Chemokine Expression by Fluticasone Propionate

(2013) Satoshi Matsukura et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease

(2013) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

(2013) Adam Collison et al.   NATURE MEDICINE

Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease

(2012) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus

(2012) Nathan W. Bartlett et al.   EMBO Molecular Medicine

Rhinovirus 16–induced IFN-α and IFN-β are deficient in bronchoalveolar lavage cells in asthmatic patients

(2012) Annemarie Sykes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms

(2012) K. Kai McKinstry et al.   JOURNAL OF CLINICAL INVESTIGATION

Number needed to treat in COPD: exacerbations versus pneumonias

(2012) Samy Suissa   THORAX

Reduced rhinovirus-specific antibodies are associated with acute exacerbations of chronic obstructive pulmonary disease requiring hospitalisation

(2012) Stephanie T Yerkovich et al.   BMC Pulmonary Medicine

Effects of Bacterial Infection on Airway Antimicrobial Peptides and Proteins in COPD

(2011) Ganapathi Iyer Parameswaran et al.   CHEST

Budesonide and Formoterol Reduce Early Innate Anti-Viral Immune Responses In Vitro

(2011) Janet M. Davies et al.   PLoS One

Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation

(2010) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Reported Pneumonia in Patients With COPD

(2010) Peter M.A. Calverley et al.   CHEST

Rhinovirus induces MUC5AC in a human infection model and in vitro via NF- B and EGFR pathways

(2010) C. A. Hewson et al.   EUROPEAN RESPIRATORY JOURNAL

Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium

(2010) Louise Slater et al.   PLoS Pathogens

Mucins, Mucus, and Sputum

(2009) Judith A. Voynow et al.   CHEST

Budesonide and formoterol inhibit inflammatory mediator production by bronchial epithelial cells infected with rhinovirus

(2009) C. L. Skevaki et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses

(2009) Q. Wang et al.   JOURNAL OF IMMUNOLOGY

Airway inflammation and anti-protease defences rapidly improve during treatment of an acute exacerbation of COPD

(2009) Sushil PANT et al.   RESPIROLOGY

Rhinovirus-Induced Major Airway Mucin Production Involves a Novel TLR3-EGFR–Dependent Pathway

(2008) Lingxiang Zhu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhaled Corticosteroids in Patients With Stable Chronic Obstructive Pulmonary Disease

(2008) M. Bradley Drummond et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

(2008) Nathan W Bartlett et al.   NATURE MEDICINE

Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production

(2008) S. D. Message et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Prevention of Chronic Obstructive Pulmonary Disease Exacerbations by Salmeterol/Fluticasone Propionate or Tiotropium Bromide

(2007) Jadwiga A. Wedzicha et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE