Evolving Concepts of Asthma

Emerging molecular phenotypes of asthma

(2015) Anuradha Ray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Gene Expression in Relation to Exhaled Nitric Oxide Identifies Novel Asthma Phenotypes with Unique Biomolecular Pathways

(2014) Brian D. Modena et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Nonallergic Asthma of Obesity. A Matter of Distal Lung Compliance

(2014) Ali Al-Alwan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

High blood eosinophil count is associated with more frequent asthma attacks in asthma patients

(2014) Trung N. Tran et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

GATA-3 Function in Innate and Adaptive Immunity

(2014) Irma Tindemans et al.   IMMUNITY

Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications

(2014) Judie A. Howrylak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

(2014) Katherine J. Baines et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data

(2014) Wei Wu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice

(2014) L. McKinley et al.   JOURNAL OF IMMUNOLOGY

The complex relationship between inflammation and lung function in severe asthma

(2014) M L Manni et al.   Mucosal Immunology

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

(2014) Elisabeth H. Bel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

External validation of blood eosinophils, FENOand serum periostin as surrogates for sputum eosinophils in asthma

(2014) A H Wagener et al.   THORAX

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study

(2014) Mario Castro et al.   Lancet Respiratory Medicine

Randomized, Double-Blind, Placebo-controlled Study of Brodalumab, a Human Anti–IL-17 Receptor Monoclonal Antibody, in Moderate to Severe Asthma

(2013) William W. Busse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exploring the Effects of Omalizumab in Allergic Asthma

(2013) Nicola A. Hanania et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

High eosinophil count: A potential biomarker for assessing successful omalizumab treatment effects

(2013) William Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects

(2013) Andrei Malinovschi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

(2013) Wendy C. Moore et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Characterization of factors associated with systemic corticosteroid use in severe asthma: Data from the Severe Asthma Research Program

(2013) Kenneth Wysocki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma

(2013) Michael C. Peters et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phenotypic predictors of response to oral glucocorticosteroids in severe asthma

(2013) Maciej Kupczyk et al.   RESPIRATORY MEDICINE

Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial

(2013) Guy G Brusselle et al.   THORAX

Obesity and Asthma

(2012) Olga Sideleva et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic

(2012) Kelly Wong McGrath et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An Association betweenl-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype

(2012) Fernando Holguin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma

(2012) Edward Piper et al.   EUROPEAN RESPIRATORY JOURNAL

Smoking and asthma: dangerous liaisons

(2012) Riccardo Polosa et al.   EUROPEAN RESPIRATORY JOURNAL

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

(2012) Guiquan Jia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Reslizumab for Poorly Controlled, Eosinophilic Asthma

(2011) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identifying adult asthma phenotypes using a clustering approach

(2011) V. Siroux et al.   EUROPEAN RESPIRATORY JOURNAL

Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation

(2011) Anne E. Dixon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Obesity and asthma: An association modified by age of asthma onset

(2011) Fernando Holguin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of Exhaled Nitric Oxide Measurement to Identify a Reactive, at-Risk Phenotype among Patients with Asthma

(2010) Raed A. Dweik et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4Rα Antagonist, in Patients with Asthma

(2010) Jonathan Corren et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

(2010) Stephane Lajoie et al.   NATURE IMMUNOLOGY

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

(2009) Wendy C. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cluster Analysis and Clinical Asthma Phenotypes

(2008) Pranab Haldar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells

(2008) K. Chibana et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease

(2008) Gary P Anderson   LANCET

Clarithromycin Targets Neutrophilic Airway Inflammation in Refractory Asthma

(2007) Jodie L. Simpson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE