Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs

The role of genetically engineered pigs in xenotransplantation research

(2015) David KC Cooper et al.   JOURNAL OF PATHOLOGY

High CTLA-4 Expression on Th17 Cells Results in Increased Sensitivity to CTLA-4 Coinhibition and Resistance to Belatacept

(2014) S. M. Krummey et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Belatacept-Based Immunosuppression inDe NovoLiver Transplant Recipients: 1-Year Experience From a Phase II Randomized Study

(2014) G. B. Klintmalm et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Transgenic expression of human cytoxic T-lymphocyte associated antigen4-Immunoglobulin (hCTLA4Ig) by porcine skin for xenogeneic skin grafting

(2014) Yong Wang et al.   TRANSGENIC RESEARCH

Regulatory T-Cell Therapy in the Induction of Transplant Tolerance

(2014) Francis C. Edozie et al.   TRANSPLANTATION

Clinical Porcine Islet Xenotransplantation Under Comprehensive Regulation

(2014) S. Matsumoto et al.   TRANSPLANTATION PROCEEDINGS

The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of xenocorneal transplantation

(2014) Mee Kum Kim et al.   XENOTRANSPLANTATION

hCTLA4-Ig transgene expression in keratocytes modulates rejection of corneal xenografts in a pig to non-human primate anterior lamellar keratoplasty model

(2014) Bertrand Vabres et al.   XENOTRANSPLANTATION

One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model

(2013) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set

(2013) Mayuko Kurome et al.   BMC BIOTECHNOLOGY

Islet xenotransplantation from genetically engineered pigs

(2013) Santosh Nagaraju et al.   Current Opinion in Organ Transplantation

Phenotypic maturation of porcine NK- and T-cell subsets

(2013) Stephanie C. Talker et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

T-cell co-stimulatory blockade in transplantation: two steps forward one step back!

(2013) Leonardo V Riella et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

CTLA4-Ig immunosuppressive activity at the level of dendritic cell/T cell crosstalk

(2013) Edda Mayer et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Treg and CTLA-4: Two intertwining pathways to immune tolerance

(2013) Lucy S.K. Walker   JOURNAL OF AUTOIMMUNITY

Production of Diabetic Offspring Using Cryopreserved Epididymal Sperm by In Vitro Fertilization and Intrafallopian Insemination Techniques in Transgenic Pigs

(2013) Kazuhiro UMEYAMA et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Alternative Immunomodulatory Strategies for Xenotransplantation: CD80/CD86-CTLA4 Pathway-Modified Immature Dendritic Cells Promote Xenograft Survival

(2013) Min Tian et al.   PLoS One

Regulatory Cells and Transplantation Tolerance

(2013) S. P. Cobbold et al.   Cold Spring Harbor Perspectives in Medicine

Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice

(2012) N. Klymiuk et al.   DIABETES

Decreased frequency of peripheral CD4+CD161+Th17-precursor cells in kidney transplant recipients on long-term therapy with Belatacept

(2012) Florian Wolfgang Rudolf Vondran et al.   TRANSPLANT INTERNATIONAL

First inducible transgene expression in porcine large animal models

(2011) Nikolai Klymiuk et al.   FASEB JOURNAL

Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family

(2011) Hélène Bour-Jordan et al.   IMMUNOLOGICAL REVIEWS

Clinical xenotransplantation: the next medical revolution?

(2011) Burcin Ekser et al.   LANCET

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Tolerogenic dendritic cells and their role in transplantation

(2011) Mohamed Ezzelarab et al.   SEMINARS IN IMMUNOLOGY

Tissue and Cellular Expression Patterns of Porcine CFTR: Similarities to and Differences From Human CFTR

(2010) Stephanie Plog et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

HLA-E/Human β2-Microglobulin Transgenic Pigs: Protection Against Xenogeneic Human Anti-Pig Natural Killer Cell Cytotoxicity

(2009) Elisabeth H. Weiss et al.   TRANSPLANTATION

Suppression of Human T-Cell Activation and Expansion of Regulatory T Cells by Pig Cells Overexpressing PD-Ligands

(2009) Annegret Plege et al.   TRANSPLANTATION

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig

(2009) Carol J. Phelps et al.   XENOTRANSPLANTATION

Boar semen variability and its effects on IVF efficiency

(2008) M.A. Gil et al.   THERIOGENOLOGY