Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline

The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood

(2019) Benjamin P. Lee et al.   BIOGERONTOLOGY

Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2

(2018) Eva Latorre et al.   Aging-US

The VEGFA 156 b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease

(2018) Eva Latorre et al.   CLINICAL SCIENCE

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Stress, cell senescence and organismal ageing

(2018) João Pedro de Magalhães et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Modulation of Tau Isoforms Imbalance Precludes Tau Pathology and Cognitive Decline in a Mouse Model of Tauopathy

(2018) Sonia Lorena Espíndola et al.   Cell Reports

Correlations between age, functional status, and the senescence-associated proteins HMGB2 and p16INK4a

(2018) Ibiyonu Lawrence et al.   GeroScience

FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence

(2018) Eva Latorre et al.   FASEB JOURNAL

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice

(2017) Stefano Tarantini et al.   GeroScience

Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells

(2017) Kevin M. Perrott et al.   GeroScience

Cerebromicrovascular dysfunction predicts cognitive decline and gait abnormalities in a mouse model of whole brain irradiation-induced accelerated brain senescence

(2017) Zoltan Ungvari et al.   GeroScience

MAPT Isoforms: Differential Transcriptional Profiles Related to 3R and 4R Splice Variants

(2017) Shufen Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans

(2016) Benjamin P. Lee et al.   AGING CELL

Dynamics of ARF regulation that control senescence and cancer

(2016) Aram Ko et al.   BMB Reports

Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease

(2016) Lan Lin et al.   HUMAN MOLECULAR GENETICS

Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons

(2016) Valentina Lacovich et al.   JOURNAL OF NEUROSCIENCE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

(2016) Kathleen M. Schoch et al.   NEURON

Context-dependent control of alternative splicing by RNA-binding proteins

(2014) Xiang-Dong Fu et al.   NATURE REVIEWS GENETICS

Dynamics of Senescent Cell Formation and Retention Revealed by p14ARF Induction in the Epidermis

(2013) R. Tokarsky-Amiel et al.   CANCER RESEARCH

Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing

(2013) María Elena Avale et al.   HUMAN MOLECULAR GENETICS

Changes in splicing factor expression are associated with advancing age in man

(2013) Alice C. Holly et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Blood Levels of Glial Fibrillary Acidic Protein (GFAP) in Patients with Neurological Diseases

(2013) Christoph A. Mayer et al.   PLoS One

Alternative mRNA Splicing from the Glial Fibrillary Acidic Protein (GFAP) Gene Generates Isoforms with Distinct Subcellular mRNA Localization Patterns in Astrocytes

(2013) Rune Thomsen et al.   PLoS One

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

(2012) C. Di Malta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

(2011) Lorna W. Harries et al.   AGING CELL

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Exon Arrays Reveal Alternative Splicing Aberrations in Parkinson’s Disease Leukocytes

(2011) Lilach Soreq et al.   Neurodegenerative Diseases

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Alternative splicing: Enhancing ability to cope with stress via transcriptome plasticity

(2011) Anna M. Mastrangelo et al.   PLANT SCIENCE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Role of Astrocytes in Brain Function and Disease

(2010) Marta Sidoryk-Wegrzynowicz et al.   TOXICOLOGIC PATHOLOGY

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE