Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease

Rbfox Proteins Regulate Splicing as Part of a Large Multiprotein Complex LASR

(2016) Andrey Damianov et al.   CELL

Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition

(2016) Yueqin Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice

(2016) Peter Langfelder et al.   NATURE NEUROSCIENCE

αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome

(2016) Xinjun Ji et al.   NUCLEIC ACIDS RESEARCH

rMAPS: RNA map analysis and plotting server for alternative exon regulation

(2016) Juw Won Park et al.   NUCLEIC ACIDS RESEARCH

Multiphasic and Dynamic Changes in Alternative Splicing during Induction of Pluripotency Are Coordinated by Numerous RNA-Binding Proteins

(2016) Benjamin Cieply et al.   Cell Reports

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes

(2015) John H. Lee et al.   NEURON

Prediction of Metabolic Gene Biomarkers for Neurodegenerative Disease by an Integrated Network-Based Approach

(2015) Qi Ni et al.   Biomed Research International

The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development

(2015) Thomas W Bebee et al.   eLife

RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression

(2015) Adam Labadorf et al.   PLoS One

A common gene expression signature in Huntington’s disease patient brain regions

(2014) Andreas Neueder et al.   BMC Medical Genomics

Transcriptome-wide Landscape of Pre-mRNA Alternative Splicing Associated with Metastatic Colonization

(2014) Zhi-xiang Lu et al.   MOLECULAR CANCER RESEARCH

Transcription, Epigenetics and Ameliorative Strategies in Huntington’s Disease: a Genome-Wide Perspective

(2014) Luis M. Valor   MOLECULAR NEUROBIOLOGY

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases

(2014) M. Narayanan et al.   Molecular Systems Biology

Huntington's disease is a four-repeat tauopathy with tau nuclear rods

(2014) Marta Fernández-Nogales et al.   NATURE MEDICINE

rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data

(2014) Shihao Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Structural basis for recognition of the third SH3 domain of full-length R85 (R85FL)/ponsin by ataxin-7

(2013) Ya-Jun Jiang et al.   FEBS LETTERS

Genomic Landscape of Transcriptional and Epigenetic Dysregulation in Early Onset Polyglutamine Disease

(2013) L. M. Valor et al.   JOURNAL OF NEUROSCIENCE

IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice

(2013) Carla Lopes et al.   MOLECULAR NEUROBIOLOGY

Widespread splicing changes in human brain development and aging

(2013) P. Mazin et al.   Molecular Systems Biology

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

(2013) K. Sathasivam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Network methods for describing sample relationships in genomic datasets: application to Huntington’s disease

(2012) Michael C Oldham et al.   BMC Systems Biology

Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis

(2012) Tamara Ratovitski et al.   CELL CYCLE

Proteomic Analysis of Wild-type and Mutant Huntingtin-associated Proteins in Mouse Brains Identifies Unique Interactions and Involvement in Protein Synthesis

(2012) Brady P. Culver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin

(2012) Jing Jin et al.   JOURNAL OF NEUROCHEMISTRY

Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease

(2012) Chiara Soldati et al.   JOURNAL OF NEUROCHEMISTRY

Genome-Wide Determination of a Broad ESRP-Regulated Posttranscriptional Network by High-Throughput Sequencing

(2012) K. A. Dittmar et al.   MOLECULAR AND CELLULAR BIOLOGY

Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease

(2012) Zhihong Guo et al.   MOVEMENT DISORDERS

Primer3—new capabilities and interfaces

(2012) Andreas Untergasser et al.   NUCLEIC ACIDS RESEARCH

Depressive symptoms in prodromal Huntington's Disease correlate with Stroop-interference related functional connectivity in the ventromedial prefrontal cortex

(2012) Paul G. Unschuld et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Crystal structure of the Cys2His2-type zinc finger domain of human DPF2

(2011) Wei Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Analysis of alternative splicing associated with aging and neurodegeneration in the human brain

(2011) J. R. Tollervey et al.   GENOME RESEARCH

Context-dependent robustness to 5′ splice site polymorphisms in human populations

(2011) Zhi-xiang Lu et al.   HUMAN MOLECULAR GENETICS

Population-specific expression analysis (PSEA) reveals molecular changes in diseased brain

(2011) Alexandre Kuhn et al.   NATURE METHODS

Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington’s disease

(2010) Doris C. V. Thu et al.   BRAIN

Aberrant RNA processing events in neurological disorders

(2010) Karen Anthony et al.   BRAIN RESEARCH

Altered microRNA regulation in Huntington's disease models

(2010) Soon-Tae Lee et al.   EXPERIMENTAL NEUROLOGY

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

(2010) Elizabeth A. Thomas et al.   HUMAN MOLECULAR GENETICS

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB

(2010) Miriam Llorian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A myriad of miRNA variants in control and Huntington’s disease brain regions detected by massively parallel sequencing

(2010) Eulàlia Martí et al.   NUCLEIC ACIDS RESEARCH

Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease

(2009) Angela Bithell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

RNA and Disease

(2009) Thomas A. Cooper et al.   CELL

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy

(2009) Robert J. Osborne et al.   HUMAN MOLECULAR GENETICS

The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

(2009) A. N. Packer et al.   JOURNAL OF NEUROSCIENCE

Huntington disease: pathogenesis, biomarkers, and approaches to experimental therapeutics

(2009) Christopher A. Ross et al.   PARKINSONISM & RELATED DISORDERS

Colocalization of Transactivation-Responsive DNA-Binding Protein 43 and Huntingtin in Inclusions of Huntington Disease

(2008) Claudia Schwab et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Huntingtin Modulates Transcription, Occupies Gene Promoters In Vivo, and Binds Directly to DNA in a Polyglutamine-Dependent Manner

(2008) C. L. Benn et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of Gene Expression in Primary Neuron Models of Huntington's Disease Shows That Polyglutamine-Related Effects on the Striatal Transcriptome May Not Be Dependent on Brain Circuitry

(2008) H. Runne et al.   JOURNAL OF NEUROSCIENCE

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

(2008) Ling-Bo Li et al.   NATURE

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

Age-dependent gene expression profile and protein expression in a transgenic rat model of Huntington's disease

(2008) Huu Phuc Nguyen et al.   Proteomics Clinical Applications

Splicing regulation: From a parts list of regulatory elements to an integrated splicing code

(2008) Z. Wang et al.   RNA

Polyglutamine neurodegeneration: protein misfolding revisited

(2008) Aislinn J. Williams et al.   TRENDS IN NEUROSCIENCES

Brain gene expression correlates with changes in behavior in the R6/1 mouse model of Huntington’s disease

(2007) A. Hodges et al.   GENES BRAIN AND BEHAVIOR