Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells

Role of Notch Signaling Pathway in Glioblastoma Multiforme Pathogenesis

(2019) Riccardo Bazzoni et al.   Cancers

Cancer Stem Cells: Acquisition, Characteristics, Therapeutic Implications, Targeting Strategies and Future Prospects

(2019) Anoop K. Yadav et al.   Stem Cell Reviews and Reports

Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue

(2019) Alessio D’Alessio et al.   Cancers

Prion protein deficiency impairs hematopoietic stem cells determination and sensitizes myeloid progenitors to irradiation

(2019) Capucine Siberchicot et al.   HAEMATOLOGICA

Elevated CD44 expression predicts poor prognosis in patients with low‑grade glioma

(2019) Qiang Dong et al.   Oncology Letters

Microenvironmental Heterogeneity in Brain Malignancies

(2019) Lucas J. M. Perus et al.   Frontiers in Immunology

Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications

(2019) Esperanza R. Matarredona et al.   Frontiers in Oncology

Overexpression of CD44 is associated with a poor prognosis in grade II/III gliomas

(2019) Chongxian Hou et al.   JOURNAL OF NEURO-ONCOLOGY

The hypoxic peri-arteriolar glioma stem cell niche, an integrated concept of five types of niches in human glioblastoma

(2018) Diana A. Aderetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Loss of STI1-mediated neuronal survival and differentiation in disease-associated mutations of prion protein

(2018) Michele Christine Landemberger et al.   JOURNAL OF NEUROCHEMISTRY

Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases

(2018) Théo Z. Hirsch et al.   MOLECULAR NEUROBIOLOGY

Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity

(2018) Katiuscia Pagano et al.   MOLECULAR NEUROBIOLOGY

The role of the prion protein in the internalization of α-synuclein amyloids

(2018) Elena De Cecco et al.   Prion

Functional and physical interaction between yeast Hsp90 and Hsp70

(2018) Andrea N. Kravats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

(2018) Stefano Thellung et al.   Cell Death & Disease

Astrocytes, the rising stars of the glioblastoma microenvironment

(2018) Mayra Brandao et al.   GLIA

Human glioblastoma arises from subventricular zone cells with low-level driver mutations

(2018) Joo Ho Lee et al.   NATURE

Contribution of the Wnt Pathway to Defining Biology of Glioblastoma

(2018) Marton Tompa et al.   NEUROMOLECULAR MEDICINE

Prions activate a p38 MAPK synaptotoxic signaling pathway

(2018) Cheng Fang et al.   PLoS Pathogens

Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma

(2018) Masahiro Nishikawa et al.   Stem Cells International

Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo

(2018) Tomas Ondrejcak et al.   JOURNAL OF NEUROSCIENCE

Cancer stem cell impact on clinical oncology

(2018) Mariel E Toledo-Guzmán et al.   World Journal of Stem Cells

Cellular prion protein targets amyloid-β fibril ends via its C-terminal domain to prevent elongation

(2017) Erin Bove-Fenderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90–231 Neurotoxic Effects in Cerebellar Granule Neurons

(2017) Stefano Thellung et al.   NEUROTOXICITY RESEARCH

Notch1 ablation radiosensitizes glioblastoma cells

(2017) Na Han et al.   Oncotarget

MGr1-Antigen/37 kDa laminin receptor precursor promotes cellular prion protein induced multi-drug-resistance of gastric cancer

(2017) Guanhong Luo et al.   Oncotarget

Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells

(2017) Rebeca Piatniczka Iglesia et al.   Stem Cell Research & Therapy

CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells

(2017) Elinn Johansson et al.   Cell Reports

Prion-Like Characteristics of Polyglutamine-Containing Proteins

(2017) Margaret M.P. Pearce et al.   Cold Spring Harbor Perspectives in Medicine

β-Amyloid Prions and the Pathobiology of Alzheimer’s Disease

(2017) Joel C. Watts et al.   Cold Spring Harbor Perspectives in Medicine

The Biological Function of the Prion Protein: A Cell Surface Scaffold of Signaling Modules

(2017) Rafael Linden   Frontiers in Molecular Neuroscience

α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication

(2017) Suzana Aulić et al.   Scientific Reports

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1

(2016) Yiwei Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

The 37-kDa laminin receptor precursor regulates the malignancy of human glioma cells

(2016) Hongjie Wu et al.   CELL BIOCHEMISTRY AND FUNCTION

The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain

(2016) Urška Slapšak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting prion-like protein doppel selectively suppresses tumor angiogenesis

(2016) Taslim A. Al-Hilal et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenotypical and Pharmacological Characterization of Stem-Like Cells in Human Pituitary Adenomas

(2016) Roberto Würth et al.   MOLECULAR NEUROBIOLOGY

Immunohistochemical expression of stem cell markers CD44 and nestin in glioblastomas: Evaluation of their prognostic significance

(2016) Elia Guadagno et al.   PATHOLOGY RESEARCH AND PRACTICE

Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide

(2016) Valentina Villa et al.   PHARMACOLOGICAL RESEARCH

The nucleo-junctional interplay of the cellular prion protein: A new partner in cancer-related signaling pathways?

(2016) Monique Rousset et al.   Prion

The Cellular Prion Protein Controls Notch Signaling in Neural Stem/Progenitor Cells

(2016) Séverine Martin-Lannerée et al.   STEM CELLS

Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells

(2016) Alessandro Corsaro et al.   Oncotarget

Glycosylphosphatidylinositol Anchor Modification Machinery Deficiency Is Responsible for the Formation of Pro-Prion Protein (PrP) in BxPC-3 Protein and Increases Cancer Cell Motility

(2015) Liheng Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cellular prion protein PrPc is a partner of the Wnt pathway in intestinal epithelial cells

(2015) Laura S. Besnier et al.   MOLECULAR BIOLOGY OF THE CELL

Anticancer effect of eupatilin on glioma cells through inhibition of the Notch-1 signaling pathway

(2015) YAWEI WANG et al.   Molecular Medicine Reports

The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis

(2015) Mohadeseh Mehrabian et al.   PLoS One

Targeting prion protein interactions in cancer

(2015) Tiago G Santos et al.   Prion

From nucleation to widespread propagation: A prion-like concept for ALS

(2015) Zuzanna Maniecka et al.   VIRUS RESEARCH

Inhibition of Notch signaling alters the phenotype of orthotopic tumors formed from glioblastoma multiforme neurosphere cells but does not hamper intracranial tumor growth regardless of endogene Notch pathway signature

(2014) Karina Kristoffersen et al.   CANCER BIOLOGY & THERAPY

Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages

(2014) Anna Carolina Carvalho da Fonseca et al.   JOURNAL OF NEUROIMMUNOLOGY

Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells

(2014) Valentina Villa et al.   MOLECULAR NEUROBIOLOGY

Disruption of prion protein–HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival

(2014) M H Lopes et al.   ONCOGENE

Prions: A model of conformational disease?

(2014) F. Morinet   PATHOLOGIE BIOLOGIE

The cellular form of the prion protein guides the differentiation of human embryonic stem cells into neuron-, oligodendrocyte-, and astrocyte-committed lineages

(2014) Young Jin Lee et al.   Prion

Functional Cross-Talk Between the Cellular Prion Protein and the Neural Cell Adhesion Molecule is Critical for Neuronal Differentiation of Neural Stem/Precursor Cells

(2014) Kanella Prodromidou et al.   STEM CELLS

Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures

(2013) Karina Kristoffersen et al.   CANCER BIOLOGY & THERAPY

CD44-Positive Cancer Stem Cells Expressing Cellular Prion Protein Contribute to Metastatic Capacity in Colorectal Cancer

(2013) L. Du et al.   CANCER RESEARCH

Significance of Prion and Prion-Like Proteins in Cancer Development, Progression and Multi-Drug Resistance

(2013) Caroline Hinton et al.   CURRENT CANCER DRUG TARGETS

CD44/Cellular prion protein interact in multidrug resistant breast cancer cells and correlate with responses to neoadjuvant chemotherapy in breast cancer patients

(2013) Yuanyuan Cheng et al.   MOLECULAR CARCINOGENESIS

The cancer stem cell niche(s): The crosstalk between glioma stem cells and their microenvironment

(2012) Alina Filatova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The status of the art of human malignant glioma management: the promising role of targeting tumor-initiating cells

(2012) Tullio Florio et al.   DRUG DISCOVERY TODAY

Role of Prion Protein Aggregation in Neurotoxicity

(2012) Alessandro Corsaro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice

(2012) D. Friedmann-Morvinski et al.   SCIENCE

Wnt Signaling

(2012) R. Nusse   Cold Spring Harbor Perspectives in Biology

Allosteric function and dysfunction of the prion protein

(2011) Rafael Linden et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Integrins and the extracellular matrix: Key mediators of development and regeneration of the sensory nervous system

(2011) Natalie J. Gardiner   Developmental Neurobiology

Neuritogenesis: the prion protein controls β1 integrin signaling activity

(2011) Damien Loubet et al.   FASEB JOURNAL

TMZ-induced PrPc/par-4 interaction promotes the survival of human glioma cells

(2011) Dongxiao Zhuang et al.   INTERNATIONAL JOURNAL OF CANCER

Microglial stress inducible protein 1 promotes proliferation and migration in human glioblastoma cells

(2011) A.C.C. da Fonseca et al.   NEUROSCIENCE

Prion Protein Expression Regulates Embryonic Stem Cell Pluripotency and Differentiation

(2011) Alberto Miranda et al.   PLoS One

Enhanced Neural Progenitor/Stem Cells Self-Renewal via the Interaction of Stress-Inducible Protein 1 with the Prion Protein

(2011) Tiago G. Santos et al.   STEM CELLS

Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction

(2011) S Thellung et al.   Cell Death & Disease

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

(2011) Darragh B. Freir et al.   Nature Communications

The fatal attraction between pro-prion and filamin A: prion as a marker in human cancers

(2010) Man-Sun Sy et al.   Biomarkers in Medicine

Expression and knockdown of cellular prion protein (PrPC) in differentiating mouse embryonic stem cells

(2010) Oscar A. Peralta et al.   DIFFERENTIATION

Filamin A mediates interactions between cytoskeletal proteins that control cell adhesion

(2010) Hugh Kim et al.   FEBS LETTERS

Pro-prion Binds Filamin A, Facilitating Its Interaction with Integrin β1, and Contributes to Melanomagenesis

(2010) Chaoyang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Signatures of Doppel Protein in Human Astrocytomas to Support Prediction in Tumor Malignancy

(2010) Paola Rognoni et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains

(2010) I. Imayoshi et al.   JOURNAL OF NEUROSCIENCE

Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells

(2010) Alessandro Didonna et al.   Molecular Neurodegeneration

Axonal prion protein is required for peripheral myelin maintenance

(2010) Juliane Bremer et al.   NATURE NEUROSCIENCE

Binding of pro-prion to filamin A: by design or an unfortunate blunder

(2010) C Li et al.   ONCOGENE

Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR

(2010) M. Roffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Interactions of Prion Protein With Intracellular Proteins: So Many Partners and no Consequences?

(2009) Krzysztof Nieznanski   CELLULAR AND MOLECULAR NEUROBIOLOGY

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer

(2009) Chaoyang Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling

(2009) Frédéric Varnat et al.   MECHANISMS OF DEVELOPMENT

Dual Modulation of ERK1/2 and p38 MAP Kinase Activities Induced by Minocycline Reverses the Neurotoxic Effects of the Prion Protein Fragment 90–231

(2009) Alessandro Corsaro et al.   NEUROTOXICITY RESEARCH

Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma

(2009) N Lindberg et al.   ONCOGENE

Notch Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts

(2009) Xing Fan et al.   STEM CELLS

The Prion's Elusive Reason for Being

(2008) Adriano Aguzzi et al.   Annual Review of Neuroscience

DNA repair and cancer stem-like cells – Potential partners in glioma drug resistance?

(2008) Tor-Christian Aase Johannessen et al.   CANCER TREATMENT REVIEWS

The role of P-glycoprotein/cellular prion protein interaction in multidrug-resistant breast cancer cells treated with paclitaxel

(2008) Q.-Q. Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Opposing effects of ERK and p38-JNK MAP kinase pathways on formation of prions in GT1-1 cells

(2008) Elin Nordström et al.   FASEB JOURNAL

Altered Neuron Excitability and Synaptic Plasticity in the Cerebellar Granular Layer of Juvenile Prion Protein Knock-Out Mice with Impaired Motor Control

(2008) F. Prestori et al.   JOURNAL OF NEUROSCIENCE

Reduced erythroid cell and erythropoietin production in response to acute anemia in prion protein-deficient (Prnp−/−) mice

(2007) Jan H. Zivny et al.   BLOOD CELLS MOLECULES AND DISEASES