Disruption of prion protein–HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival

The unconventional secretion of stress-inducible protein 1 by a heterogeneous population of extracellular vesicles

(2013) Glaucia N. M. Hajj et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Comparison between Manual and Automated Evaluations of Tissue Microarray Patterns of Protein Expression

(2013) Arthur W. Alvarenga et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Patient-Specific Orthotopic Glioblastoma Xenograft Models Recapitulate the Histopathology and Biology of Human Glioblastomas In Situ

(2013) Kyeung Min Joo et al.   Cell Reports

1H, 15N and 13C backbone resonance assignments of the TPR1 and TPR2A domains of mouse STI1

(2012) Andrzej Maciejewski et al.   Biomolecular NMR Assignments

Knockdown of Hop downregulates RhoC expression, and decreases pseudopodia formation and migration in cancer cell lines

(2012) Tarryn Willmer et al.   CANCER LETTERS

The Definition of Primary and Secondary Glioblastoma

(2012) H. Ohgaki et al.   CLINICAL CANCER RESEARCH

Endpoints for clinical trials and revised assessment in neuro-oncology

(2012) Nicholas Butowski et al.   CURRENT OPINION IN NEUROLOGY

Dynamics of the regulation of Hsp90 by the co-chaperone Sti1

(2012) Chung-Tien Lee et al.   EMBO JOURNAL

Cognitive function testing in adult brain tumor trials: lessons from a comprehensive review

(2012) Chip Caine et al.   Expert Review of Anticancer Therapy

Drug delivery strategies for the treatment of malignant gliomas

(2012) Daniela Allhenn et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells

(2012) Tomohisa Horibe et al.   Molecular Cancer

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances

(2012) P Muller et al.   ONCOGENE

Silencing Prion Protein in MDA-MB-435 Breast Cancer Cells Leads to Pleiotropic Cellular Responses to Cytotoxic Stimuli

(2012) Guohua Yu et al.   PLoS One

Secreted Stress-Induced Phosphoprotein 1 Activates the ALK2-SMAD Signaling Pathways and Promotes Cell Proliferation of Ovarian Cancer Cells

(2012) Chia-Lung Tsai et al.   Cell Reports

Silencing of cellular prion protein (PrPC) expression by DNA-antisense oligonucleotides induces autophagy-dependent cell death in glioma cells

(2011) Giulia Barbieri et al.   Autophagy

RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation

(2011) Naomi Walsh et al.   CANCER LETTERS

TMZ-induced PrPc/par-4 interaction promotes the survival of human glioma cells

(2011) Dongxiao Zhuang et al.   INTERNATIONAL JOURNAL OF CANCER

Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent

(2011) Tomohisa Horibe et al.   Journal of Translational Medicine

A Compound That Inhibits the HOP–Hsp90 Complex Formation and Has Unique Killing Effects in Breast Cancer Cell Lines

(2011) Genaro Pimienta et al.   MOLECULAR PHARMACEUTICS

The neurobiology of gliomas: from cell biology to the development of therapeutic approaches

(2011) Manfred Westphal et al.   NATURE REVIEWS NEUROSCIENCE

Standard of care therapy for malignant glioma and its effect on tumor and stromal cells

(2011) T S Jones et al.   ONCOGENE

Extracellular Heat Shock Protein (Hsp)70 and Hsp90α Assist in Matrix Metalloproteinase-2 Activation and Breast Cancer Cell Migration and Invasion

(2011) Jessica D. Sims et al.   PLoS One

Enhanced Neural Progenitor/Stem Cells Self-Renewal via the Interaction of Stress-Inducible Protein 1 with the Prion Protein

(2011) Tiago G. Santos et al.   STEM CELLS

Cellular prion protein promotes glucose uptake through the Fyn-HIF-2α-Glut1 pathway to support colorectal cancer cell survival

(2010) Qing-Quan Li et al.   CANCER SCIENCE

Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma

(2010) Hiroshi Kubota et al.   CELL STRESS & CHAPERONES

Pro-prion Binds Filamin A, Facilitating Its Interaction with Integrin β1, and Contributes to Melanomagenesis

(2010) Chaoyang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress-induced Phosphoprotein 1 as a Secreted Biomarker for Human Ovarian Cancer Promotes Cancer Cell Proliferation

(2010) Tzu-Hao Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Novel Medical Therapeutics in Glioblastomas, Including Targeted Molecular Therapies, Current and Future Clinical Trials

(2010) Eudocia C. Quant et al.   NEUROIMAGING CLINICS OF NORTH AMERICA

NAViGaTOR: Network Analysis, Visualization and Graphing Toronto

(2009) Kevin R. Brown et al.   BIOINFORMATICS

Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer

(2009) Chaoyang Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of pancreatic cancer invasion-related proteins by proteomic analysis

(2009) Naomi Walsh et al.   Proteome Science

Interventions for cognitive deficits in adults with brain tumours

(2008) Karin Gehring et al.   LANCET NEUROLOGY

Physiology of the Prion Protein

(2008) Rafael Linden et al.   PHYSIOLOGICAL REVIEWS