White Adipocyte Plasticity in Physiology and Disease

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

(2019) Christian F. Guerrero-Juarez et al.   Nature Communications

Adipogenesis induces growth inhibition of dedifferentiated liposarcoma

(2019) Yu Jin Kim et al.   CANCER SCIENCE

PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland

(2019) Purna A. Joshi et al.   Nature Communications

Focus on dedifferentiated adipocytes: characteristics, mechanisms, and possible applications

(2019) Julie Anne Côté et al.   CELL AND TISSUE RESEARCH

Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

(2019) Zhuzhen Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation

(2018) Qiong A. Wang et al.   Cell Metabolism

Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation

(2018) Rachel K. Zwick et al.   Nature Communications

TGFβ signaling and the control of myofibroblast differentiation: Implications for chronic inflammatory disorders

(2017) Jonathon M. Carthy   JOURNAL OF CELLULAR PHYSIOLOGY

Regeneration of fat cells from myofibroblasts during wound healing

(2017) Maksim V. Plikus et al.   SCIENCE

Physiological and pathological impact of exosomes of adipose tissue

(2016) Yan Zhang et al.   CELL PROLIFERATION

Liposarcoma: molecular targets and therapeutic implications

(2016) Kate Lynn J. Bill et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog

(2016) Bing Zhang et al.   GENES & DEVELOPMENT

Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice

(2016) Pengpeng Bi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style

(2016) Allyson J. Merrell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dermal Adipocytes: From Irrelevance to Metabolic Targets?

(2016) Ilja L. Kruglikov et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Adipocytes WNT5a mediated dedifferentiation: a possible target in pancreatic cancer microenvironment

(2016) Elena Zoico et al.   Oncotarget

FIZZ1-Induced Myofibroblast Transdifferentiation from Adipocytes and Its Potential Role in Dermal Fibrosis and Lipoatrophy

(2015) Vanessa Martins et al.   AMERICAN JOURNAL OF PATHOLOGY

Plasticity and Dedifferentiation within the Pancreas: Development, Homeostasis, and Disease

(2015) Sapna Puri et al.   Cell Stem Cell

Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin-Positive Intradermal Progenitors

(2015) Roberta Goncalves Marangoni et al.   Arthritis & Rheumatology

Characterization of Dedifferentiating Human Mature Adipocytes from the Visceral and Subcutaneous Fat Compartments: Fibroblast-Activation Protein Alpha and Dipeptidyl Peptidase 4 as Major Components of Matrix Remodeling

(2015) Julie Lessard et al.   PLoS One

Defining dermal adipose tissue

(2014) Ryan R. Driskell et al.   EXPERIMENTAL DERMATOLOGY

Human adipocyte function is impacted by mechanical cues

(2014) V Pellegrinelli et al.   JOURNAL OF PATHOLOGY

Adipocytes in both brown and white adipose tissue of adult mice are functionally connected via gap junctions: implications for Chagas disease

(2014) Shoshana Burke et al.   MICROBES AND INFECTION

Single-cell RNA-seq: advances and future challenges

(2014) Antoine-Emmanuel Saliba et al.   NUCLEIC ACIDS RESEARCH

Epidermal Wnt/ -catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

(2014) G. Donati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Cell Genomics: Advances and Future Perspectives

(2014) Iain C. Macaulay et al.   PLoS Genetics

Characterization of Cre recombinase models for the study of adipose tissue

(2014) Elise Jeffery et al.   Adipocyte

Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer

(2013) L. Bochet et al.   CANCER RESEARCH

Weighing in on Adipocyte Precursors

(2013) Ryan Berry et al.   Cell Metabolism

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Characterization of the adipocyte cellular lineage in vivo

(2013) Ryan Berry et al.   NATURE CELL BIOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

(2013) Aaron M Cypess et al.   NATURE MEDICINE

Correction: Development of the Mouse Dermal Adipose Layer Occurs Independently of Subcutaneous Adipose Tissue and Is Marked by Restricted Early Expression of FABP4

(2013) Kamila Wojciechowicz et al.   PLoS One

Mesenchymal Stem Cells in Tissue Repair

(2013) Amy M. DiMarino et al.   Frontiers in Immunology

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells

(2012) Khanh-Van Tran et al.   Cell Metabolism

Human Dedifferentiated Adipocytes Show Similar Properties to Bone Marrow-Derived Mesenchymal Stem Cells

(2012) Antonella Poloni et al.   STEM CELLS

Consecutive Positive Feedback Loops Create a Bistable Switch that Controls Preadipocyte-to-Adipocyte Conversion

(2012) Byung Ouk Park et al.   Cell Reports

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

(2011) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

(2011) B. Dirat et al.   CANCER RESEARCH

Clinical and molecular approaches to well differentiated and dedifferentiated liposarcoma

(2011) Aimee M Crago et al.   CURRENT OPINION IN ONCOLOGY

Secretome analysis of rat adipose tissues shows location-specific roles for each depot type

(2011) Arturo Roca-Rivada et al.   Journal of Proteomics

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

(2011) Chris Jopling et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Architecture and the extracellular matrix: the still unappreciated components of the adipose tissue

(2011) A. Divoux et al.   Obesity Reviews

Subcutaneous adipose tissue classification

(2010) A. Sbarbati et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Activation of Canonical Wingless-type MMTV Integration Site Family (Wnt) Signaling in Mature Adipocytes Increases β-Catenin Levels and Leads to Cell Dedifferentiation and Insulin Resistance

(2010) Birgit Gustafson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular models for understanding adipogenesis, adipose dysfunction, and obesity

(2010) Andrea Armani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific

(2010) S. M. Majka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rosiglitazone Abrogates Bleomycin-Induced Scleroderma and Blocks Profibrotic Responses Through Peroxisome Proliferator-Activated Receptor-γ

(2009) Minghua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Transdifferentiation properties of adipocytes in the adipose organ

(2009) Saverio Cinti   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Re-expression of GATA2 Cooperates with Peroxisome Proliferator-activated Receptor-γ Depletion to Revert the Adipocyte Phenotype

(2009) Michael Schupp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dedifferentiated fat cells convert to cardiomyocyte phenotype and repair infarcted cardiac tissue in rats

(2009) Medet Jumabay et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues

(2009) J. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Physiological Transdifferentiation of Adult Adipose Cells

(2009) Rita De Matteis et al.   STEM CELLS

Establishment of a preadipocyte cell line derived from mature adipocytes of GFP transgenic mice and formation of adipose tissue

(2008) Hiroyuki Nobusue et al.   CELL AND TISSUE RESEARCH

Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism

(2008) Thien T. Tran et al.   Cell Metabolism

PPAR  and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale

(2008) M. I. Lefterova et al.   GENES & DEVELOPMENT

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

(2008) T. Khan et al.   MOLECULAR AND CELLULAR BIOLOGY

p16 Immunohistochemistry as an Alternative Marker to Distinguish Atypical Lipomatous Tumor From Deep-seated Lipoma

(2008) Mai He et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY