TGFβ signaling and the control of myofibroblast differentiation: Implications for chronic inflammatory disorders

Targeted inhibition of Focal Adhesion Kinase Attenuates Cardiac Fibrosis and Preserves Heart Function in Adverse Cardiac Remodeling

(2017) Jie Zhang et al.   Scientific Reports

The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis

(2016) Yu Bo Yang Sun et al.   DIFFERENTIATION

YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis

(2016) S. G. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Signaling Receptors for TGF-β Family Members

(2016) Carl-Henrik Heldin et al.   Cold Spring Harbor Perspectives in Biology

Non-Smad Signaling Pathways of the TGF-β Family

(2016) Ying E. Zhang   Cold Spring Harbor Perspectives in Biology

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

(2016) Pam Speight et al.   Nature Communications

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation

(2016) Jon M. Carthy et al.   Scientific Reports

YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts

(2015) Bram Piersma et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of Matrix Metalloproteinase Activity Reverses Corneal Endothelial-Mesenchymal Transition

(2015) Wei-Ting Ho et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis

(2015) Thomas H. Sisson et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Distinct Polarity Cues Direct Taz/Yap and TGFβ Receptor Localization to Differentially Control TGFβ-Induced Smad Signaling

(2015) Masahiro Narimatsu et al.   DEVELOPMENTAL CELL

Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2

(2015) Jon M. Carthy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Crosstalk between Hippo and TGFβ: Subcellular Localization of YAP/TAZ/Smad Complexes

(2015) Karin Grannas et al.   JOURNAL OF MOLECULAR BIOLOGY

Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin-Positive Intradermal Progenitors

(2015) Roberta Goncalves Marangoni et al.   Arthritis & Rheumatology

Opposing Roles for Smad2 and Smad3 in Peritoneal Fibrosis in Vivo and in Vitro

(2014) Wen-Juan Duan et al.   AMERICAN JOURNAL OF PATHOLOGY

Integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction

(2014) Vincent Sarrazy et al.   CARDIOVASCULAR RESEARCH

TGF- -induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms

(2014) M. A. Scharenberg et al.   JOURNAL OF CELL SCIENCE

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

The role of RhoA and cytoskeleton in myofibroblast transformation in hyperoxic lung fibrosis

(2013) Jixiang Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel Rho/MRTF/SRF Inhibitors Block Matrix-stiffness and TGF-β–Induced Fibrogenesis in Human Colonic Myofibroblasts

(2013) Laura A. Johnson et al.   INFLAMMATORY BOWEL DISEASES

miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1

(2013) Christian Lacks Lino Cardenas et al.   PLoS Genetics

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

TGF-β signalling and its role in cancer progression and metastasis

(2012) Yvette Drabsch et al.   CANCER AND METASTASIS REVIEWS

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Interactions Between β-Catenin and Transforming Growth Factor-β Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP)

(2012) Beiyun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of circulating fibrocytes in inflammation and autoimmunity

(2012) Carole L. Galligan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Actin–MRTF–SRF Gene Regulatory Axis and Myofibroblast Differentiation

(2012) Eric M. Small   Journal of Cardiovascular Translational Research

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

The role of the myofibroblast in tumor stroma remodeling

(2012) Marcela Otranto et al.   Cell Adhesion & Migration

Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β

(2011) Nathan Sandbo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Targeted Inhibition of  -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis

(2011) S. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

WNT3A induces a contractile and secretory phenotype in cultured vascular smooth muscle cells that is associated with increased gap junction communication

(2011) Jon M Carthy et al.   LABORATORY INVESTIGATION

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

β-Catenin Mediates Mechanically Regulated, Transforming Growth Factor-β1–Induced Myofibroblast Differentiation of Aortic Valve Interstitial Cells

(2010) Jan-Hung Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Smaddening Complexity: The Role of Smad3 in Epithelial-Myofibroblast Transition

(2010) András Masszi et al.   CELLS TISSUES ORGANS

Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

(2010) Eric M. Small et al.   CIRCULATION RESEARCH

Corneal myofibroblast generation from bone marrow-derived cells

(2010) Flavia L. Barbosa et al.   EXPERIMENTAL EYE RESEARCH

Micro-RNA-21 regulates TGF-β-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction

(2010) Qin Yao et al.   INTERNATIONAL JOURNAL OF CANCER

Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3

(2010) András Masszi et al.   JOURNAL OF CELL BIOLOGY

Evolving challenges in hepatic fibrosis

(2010) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Coactivator with PDZ-binding Motif Is Essential for Normal Alveolarization in Mice

(2009) Akihisa Mitani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Critical Role of Serum Response Factor in Pulmonary Myofibroblast Differentiation Induced by TGF-β

(2009) Nathan Sandbo et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis

(2009) Nicole Reich et al.   ARTHRITIS AND RHEUMATISM

Transcriptional regulation of SM22α by Wnt3a: Convergence with TGFβ1/Smad signaling at a novel regulatory element

(2009) Shawn L. Shafer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

TGF-β-mediated activation of RhoA signalling is required for efficient V12HaRas and V600EBRAF transformation

(2008) Y M Fleming et al.   ONCOGENE

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1

(2008) R. Eferl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive pulmonary fibrosis is mediated by TGF-β isoform 1 but not TGF-β3

(2007) Kjetil Ask et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY