Heterogeneity of Vascular Endothelial Cells, De Novo Arteriogenesis and Therapeutic Implications in Pancreatic Neuroendocrine Tumors

Antibody-Drug Conjugates (ADC) Against Cancer Stem-Like Cells (CSC)—Is There Still Room for Optimism?

(2019) Fabrizio Marcucci et al.   Frontiers in Oncology

Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells

(2019) Petra Jagust et al.   Frontiers in Pharmacology

Progression-free survival (PFS) and subgroups analyses of lenvatinib in patients (pts) with G1/G2 advanced pancreatic (panNETs) and gastrointestinal (giNETs) neuroendocrine tumors (NETs): Updated results from the phase II TALENT trial (GETNE 1509).

(2019) Jaume Capdevila et al.   JOURNAL OF CLINICAL ONCOLOGY

Sunitinib in patients with pancreatic neuroendocrine tumors: update of safety data

(2019) Juan W Valle et al.   Future Oncology

The SUNEVO (GETNE-1408) trial to evaluate the activity and safety of thecombination of sunitinib with evofosfamide (TH-302) in patients with G1/G2 metastatic pancreatic neuroendocrine tumours (pNETs) naïve forsystemic treatment: A phase II study of the Spanish Task Force Group for Neuroendocrine and Endocrine Tumors (GETNE).

(2019) Enrique Grande et al.   JOURNAL OF CLINICAL ONCOLOGY

Translating Ribosome Affinity Purification (TRAP) for RNA Isolation from Endothelial Cells In vivo

(2019) Patrick Moran et al.   Jove-Journal of Visualized Experiments

Lenvatinib, a molecule with versatile application: from preclinical evidence to future development in anti-cancer treatment

(2019) Monica Capozzi et al.   Cancer Management and Research

Ultrafine Particle Exposure Reveals the Importance of FOXO1/Notch Activation Complex for Vascular Regeneration

(2018) Kyung In Baek et al.   ANTIOXIDANTS & REDOX SIGNALING

NOTCH regulation of the endothelial cell phenotype

(2018) Julia J. Mack et al.   CURRENT OPINION IN HEMATOLOGY

Paracrine interactions of cancer-associated fibroblasts, macrophages and endothelial cells

(2018) Roberto Ronca et al.   CURRENT OPINION IN ONCOLOGY

FoxO1 transcriptional activities in VEGF expression and beyond: a key regulator in functional angiogenesis?

(2018) Bin Ren   JOURNAL OF PATHOLOGY

VEGF/PKD-1 signaling mediates arteriogenic gene expression and angiogenic responses in reversible human microvascular endothelial cells with extended lifespan

(2018) Brad Best et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Efficacy and Safety of Sunitinib in Patients With Well-Differentiated Pancreatic Neuroendocrine Tumours

(2018) Eric Raymond et al.   NEUROENDOCRINOLOGY

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis

(2018) Andras Ladanyi et al.   ONCOGENE

Sunitinib in patients with pre-treated pancreatic neuroendocrine tumors: A real-world study

(2018) Maria Rinzivillo et al.   PANCREATOLOGY

Notch3 as a novel therapeutic target in metastatic medullary thyroid cancer

(2018) Irene Lou et al.   SURGERY

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

(2018) Kristiaan J. Lenos et al.   NATURE CELL BIOLOGY

Rovalpituzumab Tesirine: A Novel DLL3-Targeting Antibody–Drug Conjugate

(2018) Bilal H. Lashari et al.   Drugs in research & development

Autotaxin upregulated by STAT3 activation contributes to invasion in pancreatic neuroendocrine neoplasms

(2018) Linfei Yang et al.   Endocrine Connections

Sprouting strategies and dead ends in anti-angiogenic targeting of NETs

(2017) Patricia Carrasco et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The Potential of Combined Immunotherapy and Antiangiogenesis for the Synergistic Treatment of Advanced NSCLC

(2017) Christian Manegold et al.   Journal of Thoracic Oncology

Pancreatic Neuroendocrine Tumors and EMT Behavior Are Driven by the CSC Marker DCLK1

(2017) Yu Ikezono et al.   MOLECULAR CANCER RESEARCH

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Stem cell plasticity enables hair regeneration following Lgr5+ cell loss

(2017) Joerg D. Hoeck et al.   NATURE CELL BIOLOGY

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

(2017) Arianna Fumagalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

(2017) Jarno Drost et al.   SCIENCE

Delta-Like 4 Activates Notch 3 to Regulate Self-Renewal in Skeletal Muscle Stem Cells

(2017) SiewHui Low et al.   STEM CELLS

Diet-induced obesity links to ER positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling

(2017) Liuyi Dong et al.   Oncotarget

Cancer cells exhibit clonal diversity in phenotypic plasticity

(2017) Robert Austin Mathis et al.   Open Biology

The Vascular Wall: a Plastic Hub of Activity in Cardiovascular Homeostasis and Disease

(2017) Cassandra P. Awgulewitsch et al.   Current Cardiology Reports

How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors

(2017) Annalisa Zecchin et al.   Frontiers in Immunology

John Hunter and the origin of the term “angiogenesis”

(2016) Paola Lenzi et al.   ANGIOGENESIS

Enhancer of zest homolog 2 (EZH2) expression in well and moderately differentiated pancreatic neuroendocrine tumor (pNET)

(2016) R. Marconcini et al.   ANNALS OF ONCOLOGY

Sunitinib in Pancreatic Neuroendocrine Tumors: Updated Progression-Free Survival and Final Overall Survival From a Phase III Randomized Study

(2016) S. Faivre et al.   ANNALS OF ONCOLOGY

Antiangiogenic Therapy in Pancreatic Neuroendocrine Tumors

(2016) MONICA CAPOZZI et al.   ANTICANCER RESEARCH

LPA/PKD-1-FoxO1 Signaling Axis Mediates Endothelial Cell CD36 Transcriptional Repression and Proangiogenic and Proarteriogenic ReprogrammingHighlights

(2016) Bin Ren et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch3 expression correlates with thyroid cancer differentiation, induces apoptosis, and predicts disease prognosis

(2016) Yash R. Somnay et al.   CANCER

G protein-coupled receptors as promising cancer targets

(2016) Ying Liu et al.   CANCER LETTERS

Targeting the Angiopoietin-2/Tie-2 axis in conjunction with VEGF signal interference

(2016) Nikolett M. Biel et al.   CANCER LETTERS

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumor cell vascular mimicry: Novel targeting opportunity in melanoma

(2016) Mary J.C. Hendrix et al.   PHARMACOLOGY & THERAPEUTICS

Identification of tumorigenic cells and therapeutic targets in pancreatic neuroendocrine tumors

(2016) Geoffrey Wayne Krampitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity

(2016) Lei Yuan et al.   Nature Communications

Notch Signaling in Neuroendocrine Tumors

(2016) Judy S. Crabtree et al.   Frontiers in Oncology

Tumor Stroma, Tumor Blood Vessels, and Antiangiogenesis Therapy

(2015) Harold F. Dvorak   CANCER JOURNAL

Abstract A09: Diet-induced obesity promotes breast cancer progression by LPA-signaling-mediated functional changes of mitochondria and angiogenesis

(2015) Ye Yuan et al.   CANCER RESEARCH

TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma

(2015) Naoki Oshimori et al.   CELL

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

(2015) James G. Ryall et al.   Cell Stem Cell

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis

(2015) Elvin Wagenblast et al.   NATURE

Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma

(2015) L Zhou et al.   ONCOGENE

What is an adult stem cell?

(2015) H. Clevers   SCIENCE

A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo

(2015) Laura R. Saunders et al.   Science Translational Medicine

Bevacizumab plus octreotide and metronomic capecitabine in patients with metastatic well-to-moderately differentiated neuroendocrine tumors: the xelbevoct study

(2014) Alfredo Berruti et al.   BMC CANCER

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Abstract LB-338: A novel LPA-PKD1-FoxO1 pathway in endothelial cells provides an angiogenic switch via down-regulation of CD36 transcription and induction of arteriogenic responses .

(2014) Jacob D. Kohlenberg et al.   CANCER RESEARCH

Neuroendocrine Tumors of the Lung: Hystological Classification, Diagnosis, Traditional and New Therapeutic Approaches

(2014) A. Cueto et al.   CURRENT MEDICINAL CHEMISTRY

Angiogenesis and vascular maturation in neuroendocrine tumors

(2014) Samaneh Yazdani et al.   HUMAN PATHOLOGY

Tumor-Suppressor Role of Notch3 in Medullary Thyroid Carcinoma Revealed by Genetic and Pharmacological Induction

(2014) R. Jaskula-Sztul et al.   MOLECULAR CANCER THERAPEUTICS

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

(2014) Charlie G. Buffie et al.   NATURE

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis

(2014) Katie Bentley et al.   NATURE CELL BIOLOGY

Lanreotide in Metastatic Enteropancreatic Neuroendocrine Tumors

(2014) Martyn E. Caplin et al.   NEW ENGLAND JOURNAL OF MEDICINE

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Cancer Stem Cell-Specific Scavenger Receptor CD36 Drives Glioblastoma Progression

(2014) James S. Hale et al.   STEM CELLS

Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade

(2014) Nicolò Rigamonti et al.   Cell Reports

Somatostatin Analogs Therapy in Gastroenteropancreatic Neuroendocrine Tumors: Current Aspects and New Perspectives

(2014) Roberto Baldelli et al.   Frontiers in Endocrinology

Multiple Microvascular Alterations in Pancreatic Islets and Neuroendocrine Tumors of a Men1 Mouse Model

(2013) Xia Chu et al.   AMERICAN JOURNAL OF PATHOLOGY

The targeted therapy revolution in neuroendocrine tumors: in search of biomarkers for patient selection and response evaluation

(2013) Sara De Dosso et al.   CANCER AND METASTASIS REVIEWS

Continuous Clonal Labeling Reveals Small Numbers of Functional Stem Cells in Intestinal Crypts and Adenomas

(2013) Sarah Kozar et al.   Cell Stem Cell

Endothelial Cell–Dependent Regulation of Arteriogenesis

(2013) Filipa Moraes et al.   CIRCULATION RESEARCH

Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

(2013) Daniel J. Nolan et al.   DEVELOPMENTAL CELL

The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis

(2013) Anthony Lanahan et al.   DEVELOPMENTAL CELL

Placental growth factor supports neuroendocrine tumor growth and predicts disease prognosis in patients

(2013) Georg Hilfenhaus et al.   ENDOCRINE-RELATED CANCER

Regulation Of Angiogenesis By Phospholipid Lysophosphatidic Acid

(2013) Bin Ren   Frontiers in Bioscience-Landmark

Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway

(2012) Vesselina G. Cooke et al.   CANCER CELL

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target

(2012) B. Sitohy et al.   CANCER RESEARCH

SnapShot: Tumor Angiogenesis

(2012) Rakesh K. Jain et al.   CELL

Dynamical Systems Approach to Endothelial Heterogeneity

(2012) Erzsébet Ravasz Regan et al.   CIRCULATION RESEARCH

Heterogeneity of the tumor vasculature: the need for new tumor blood vessel type-specific targets

(2012) Janice A. Nagy et al.   CLINICAL & EXPERIMENTAL METASTASIS

Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

(2012) Federica Maione et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes

(2012) Nicolas Skuli et al.   JOURNAL OF CLINICAL INVESTIGATION

Prospective Study of Bevacizumab Plus Temozolomide in Patients With Advanced Neuroendocrine Tumors

(2012) Jennifer A. Chan et al.   JOURNAL OF CLINICAL ONCOLOGY

Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway

(2012) He Wang et al.   MODERN PATHOLOGY

Defining the mode of tumour growth by clonal analysis

(2012) Gregory Driessens et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

(2012) A. G. Schepers et al.   SCIENCE

Brief Report: Intravital Imaging of Cancer Stem Cell Plasticity in Mammary Tumors

(2012) Anoek Zomer et al.   STEM CELLS

Analysis of the expression of the Notch3 receptor protein in adult lung cancer

(2012) MIN ZHOU et al.   Oncology Letters

Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors

(2012) Barbara Sennino et al.   Cancer Discovery

Priming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase

(2011) S. Kazerounian et al.   BLOOD

Lysophosphatidic acid suppresses endothelial cell CD36 expression and promotes angiogenesis via a PKD-1-dependent signaling pathway

(2011) B. Ren et al.   BLOOD

Tumor-Surrogate Blood Vessel Subtypes Exhibit Differential Susceptibility to Anti-VEGF Therapy

(2011) B. Sitohy et al.   CANCER RESEARCH

The Evolution of Endothelial Regulatory Paradigms in Cancer Biology and Vascular Repair

(2011) J. W. Franses et al.   CANCER RESEARCH

AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

(2011) Stephen M. Sykes et al.   CELL

Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

(2011) Piyush B. Gupta et al.   CELL

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Brivanib, a Dual FGF/VEGF Inhibitor, Is Active Both First and Second Line against Mouse Pancreatic Neuroendocrine Tumors Developing Adaptive/Evasive Resistance to VEGF Inhibition

(2011) Elizabeth Allen et al.   CLINICAL CANCER RESEARCH

The Epidemiology of Gastroenteropancreatic Neuroendocrine Tumors

(2011) Ben Lawrence et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Everolimus and sunitinib: from mouse models to treatment of pancreatic neuroendocrine tumors

(2011) Theodore Liakakos et al.   Future Oncology

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells

(2011) Xin Zhang et al.   NATURE CELL BIOLOGY

Sunitinib Malate for the Treatment of Pancreatic Neuroendocrine Tumors

(2011) Eric Raymond et al.   NEW ENGLAND JOURNAL OF MEDICINE

Everolimus for Advanced Pancreatic Neuroendocrine Tumors

(2011) James C. Yao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stromal Endothelial Cells Directly Influence Cancer Progression

(2011) J. W. Franses et al.   Science Translational Medicine

ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish

(2010) Bin Ren et al.   JOURNAL OF CLINICAL INVESTIGATION

Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma

(2010) Iris Helfrich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Collateral Capillary Arterialization following Arteriolar Ligation in Murine Skeletal Muscle

(2010) FEILIM MAC GABHANN et al.   MICROCIRCULATION

Endogenous RhoG Is Rapidly Activated after Epidermal Growth Factor Stimulation through Multiple Guanine-Nucleotide Exchange Factors

(2010) Thomas Samson et al.   MOLECULAR BIOLOGY OF THE CELL

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

VEGF Secretion by Neuroendocrine Tumor Cells Is Inhibited by Octreotide and by Inhibitors of the PI3K/AKT/mTOR Pathway

(2010) Karine Villaume et al.   NEUROENDOCRINOLOGY

Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway

(2010) S Eliasz et al.   ONCOGENE

Heterogeneity of the Tumor Vasculature

(2010) Janice Nagy et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Endothelial deletion of hypoxia-inducible factor-2  (HIF-2 ) alters vascular function and tumor angiogenesis

(2009) N. Skuli et al.   BLOOD

Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

(2009) Shuying Liu et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

A Double Hit to Kill Tumor and Endothelial Cells by TRAIL and Antiangiogenic 3TSR

(2009) B. Ren et al.   CANCER RESEARCH

Oxygen Sensors at the Crossroad of Metabolism

(2009) Julián Aragonés et al.   Cell Metabolism

Surgical management of pancreatic endocrine tumors

(2009) Volker Fendrich et al.   Nature Reviews Clinical Oncology

Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival

(2008) T. R. Halfdanarson et al.   ANNALS OF ONCOLOGY

Hypoxia-inducible factor (HIF)-1  directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF)

(2008) Z.-B. Han et al.   CARCINOGENESIS

Somatostatin analogues in the control of neuroendocrine tumours: efficacy and mechanisms

(2008) S. Grozinsky-Glasberg et al.   ENDOCRINE-RELATED CANCER

Differential roles of PDGFR-α and PDGFR-β in angiogenesis and vessel stability

(2008) Junhang Zhang et al.   FASEB JOURNAL

Gastrointestinal Neuroendocrine Tumors: Pancreatic Endocrine Tumors

(2008) David C. Metz et al.   GASTROENTEROLOGY