Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma

A phase I study of cabozantinib (XL184) in patients with renal cell cancer

(2014) T. K. Choueiri et al.   ANNALS OF ONCOLOGY

Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET

(2014) Erinn B. Rankin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the Hepatocyte Growth Factor/c-Met Signaling Pathway in Renal Cell Carcinoma

(2013) Lauren C. Harshman et al.   CANCER JOURNAL

Emerging antiangiogenics for renal cancer

(2013) Charlotte Domblides et al.   EXPERT OPINION ON EMERGING DRUGS

Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy

(2013) W Leconet et al.   ONCOGENE

In Vitro and In Vivo Activity of Cabozantinib (XL184), an Inhibitor of RET, MET, and VEGFR2, in a Model of Medullary Thyroid Cancer

(2013) Frauke Bentzien et al.   THYROID

c-Met is a prognostic marker and potential therapeutic target in clear cell renal cell carcinoma

(2012) G. T. Gibney et al.   ANNALS OF ONCOLOGY

Rapid Angiogenesis Onset after Discontinuation of Sunitinib Treatment of Renal Cell Carcinoma Patients

(2012) A. W. Griffioen et al.   CLINICAL CANCER RESEARCH

Axl is essential for VEGF-A-dependent activation of PI3K/Akt

(2012) Guo-Xiang Ruan et al.   EMBO JOURNAL

Cabozantinib in Patients With Advanced Prostate Cancer: Results of a Phase II Randomized Discontinuation Trial

(2012) David C. Smith et al.   JOURNAL OF CLINICAL ONCOLOGY

TNF-  Induces Epithelial-Mesenchymal Transition of Renal Cell Carcinoma Cells via a GSK3 -Dependent Mechanism

(2012) M.-Y. Ho et al.   MOLECULAR CANCER RESEARCH

Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair

(2012) Xue Zhang et al.   NATURE GENETICS

MET: a promising anticancer therapeutic target

(2012) Solange Peters et al.   Nature Reviews Clinical Oncology

Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays

(2012) T S Gujral et al.   ONCOGENE

Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors

(2012) Barbara Sennino et al.   Cancer Discovery

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Hepatocyte growth factor-induced c-Src-phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway inhibits dendritic cell activation by blocking IκB kinase activity

(2011) Eshu Singhal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers

(2011) Michela Garofalo et al.   NATURE MEDICINE

Gene and protein expression markers of response to combined antiangiogenic and epidermal growth factor targeted therapy in renal cell carcinoma

(2010) D. Tsavachidou-Fenner et al.   ANNALS OF ONCOLOGY

Interleukin-8 Mediates Resistance to Antiangiogenic Agent Sunitinib in Renal Cell Carcinoma

(2010) D. Huang et al.   CANCER RESEARCH

AXL Is an Essential Factor and Therapeutic Target for Metastatic Ovarian Cancer

(2010) E. B. Rankin et al.   CANCER RESEARCH

Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors

(2010) Rachel MA Linger et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies

(2010) X Ye et al.   ONCOGENE

Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors

(2009) R Kumar et al.   BRITISH JOURNAL OF CANCER

Patterns of disease progression in metastatic renal cell carcinoma patients treated with antivascular agents and interferon

(2009) Elizabeth R. Plimack et al.   CANCER

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Differential Expression of Axl and Gas6 in Renal Cell Carcinoma Reflecting Tumor Advancement and Survival

(2009) A. Gustafsson et al.   CLINICAL CANCER RESEARCH

Cytoplasmic ACK1 Interaction with Multiple Receptor Tyrosine Kinases Is Mediated by Grb2

(2009) Lin Pao-Chun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase II Presurgical Feasibility Study of Bevacizumab in Untreated Patients With Metastatic Renal Cell Carcinoma

(2009) Eric Jonasch et al.   JOURNAL OF CLINICAL ONCOLOGY

Gas6 and the Receptor Tyrosine Kinase Axl in Clear Cell Renal Cell Carcinoma

(2009) Anna Gustafsson et al.   PLoS One

Cytoplasmic Sequestration of p27 via AKT Phosphorylation in Renal Cell Carcinoma

(2008) J. Kim et al.   CLINICAL CANCER RESEARCH