Mitochondrial Dysfunction in Aging and Cancer

Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis

(2019) Alessandro Carrer et al.   Cancer Discovery

Revisiting Telomere Shortening in Cancer

(2019) Keiji Okamoto et al.   Cells

Mitochondrial DNA: the overlooked oncogenome?

(2019) Payam A. Gammage et al.   BMC BIOLOGY

Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single cell resolution

(2019) Ryan O'Hara et al.   GENOME RESEARCH

Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction

(2019) Wei Qian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

Degraded Mitochondrial DNA is a Newly Identified Subtype of the Damage Associated Molecular Pattern (DAMP) Family and Possible Trigger of Neurodegeneration

(2018) Alex Mathew et al.   JOURNAL OF ALZHEIMERS DISEASE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Characterization of the human homozygous R182W POLG2 mutation in mitochondrial DNA depletion syndrome

(2018) Kirsten E. Hoff et al.   PLoS One

Author Correction: Mitochondrial DNA synthesis fuels NLRP3 inflammasome

(2018) Rebecca C. Coll et al.   CELL RESEARCH

Role of the NLRP3 inflammasome in cancer

(2018) Maryam Moossavi et al.   Molecular Cancer

Synergistic Effects of thein cisT251I and P587L Mitochondrial DNA Polymerase γ Disease Mutations

(2017) Karen L. DeBalsi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways

(2017) Snehal N. Chaudhari et al.   Nature Communications

Mitochondrial metabolites: undercover signalling molecules

(2017) Christian Frezza   Interface Focus

Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer

(2017) Flora Guerra et al.   Frontiers in Oncology

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents AtherosclerosisNovelty and Significance

(2016) Gantsetseg Tumurkhuu et al.   CIRCULATION RESEARCH

Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis

(2016) Adeel Safdar et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

(2016) Edoardo Gaude et al.   Nature Communications

Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number

(2016) Manja Wachsmuth et al.   PLoS Genetics

Mitochondrial DNA copy number variation across human cancers

(2016) Ed Reznik et al.   eLife

Aging and DNA damage in humans: a meta-analysis study

(2016) Jorge Pinto Soares et al.   Aging-US

Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

(2015) Zhengwei Xie et al.   CELL

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Global variability in gene expression and alternative splicing is modulated by mitochondrial content

(2015) Raul Guantes et al.   GENOME RESEARCH

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

(2015) Denise N. Bronner et al.   IMMUNITY

Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ

(2015) Christal D. Sohl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

(2015) E. H. Blackburn et al.   SCIENCE

Mitochondrial dysfunction in cancer chemoresistance

(2014) Nicoletta Guaragnella et al.   BIOCHEMICAL PHARMACOLOGY

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation

(2014) Gopinath Sutendra et al.   CELL

Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan

(2014) Tobias Eisenberg et al.   Cell Metabolism

Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress

(2014) Daniel T. Shaughnessy et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

In D-loop: 40years of mitochondrial 7S DNA

(2014) Thomas J. Nicholls et al.   EXPERIMENTAL GERONTOLOGY

Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice

(2014) Jill E. Kolesar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

(2014) Jonas Mengel-From et al.   HUMAN GENETICS

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

(2014) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternally transmitted mitochondrial DNA mutations can reduce lifespan

(2014) Jaime M. Ross et al.   Scientific Reports

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

The Major Reverse Transcriptase-Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis

(2013) I. Listerman et al.   CANCER RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Use of Anti-Cancer Drugs, Mitocans, to Enhance the Immune Responses against Tumors

(2013) T. Hahn et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics

(2013) Manti Guha et al.   MITOCHONDRION

Germline mitochondrial DNA mutations aggravate ageing and can impair brain development

(2013) Jaime M. Ross et al.   NATURE

Mitochondrial retrograde signaling induces epithelial–mesenchymal transition and generates breast cancer stem cells

(2013) M Guha et al.   ONCOGENE

Induction of epithelial–mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent

(2013) F M Davis et al.   ONCOGENE

HIV Treatment and Associated Mitochondrial Pathology

(2013) Kristian Gardner et al.   TOXICOLOGIC PATHOLOGY

The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update

(2013) M. Alexeyev et al.   Cold Spring Harbor Perspectives in Biology

Ultra-Sensitive Sequencing Reveals an Age-Related Increase in Somatic Mitochondrial Mutations That Are Inconsistent with Oxidative Damage

(2013) Scott R. Kennedy et al.   PLoS Genetics

Mitochondrial DNA depletion sensitizes cancer cells to PARP inhibitors by translational and post-translational repression of BRCA2

(2013) A A Arbini et al.   Oncogenesis

Sowing the seeds of cancer

(2012) Branca Pereira et al.   CURRENT OPINION IN ONCOLOGY

Importance of glycolysis and oxidative phosphorylation in advanced melanoma

(2012) Jonhan Ho et al.   Molecular Cancer

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria

(2011) Nilesh K. Sharma et al.   NUCLEIC ACIDS RESEARCH

A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction

(2010) Olga A. Kovalenko et al.   AGING CELL

Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria

(2010) Dao-Fu Dai et al.   AGING CELL

Role of mitochondrial reactive oxygen species in osteoclast differentiation

(2010) Satish Srinivasan et al.   Annals of the New York Academy of Sciences

hTERT Overexpression Alleviates Intracellular ROS Production, Improves Mitochondrial Function, and Inhibits ROS-Mediated Apoptosis in Cancer Cells

(2010) I. R. Indran et al.   CANCER RESEARCH

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations

(2010) Hsiuchen Chen et al.   CELL

Telomeres, lifestyle, cancer, and aging

(2010) Masood A Shammas   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Expression of NES-hTERT in Cancer Cells Delays Cell Cycle Progression and Increases Sensitivity to Genotoxic Stress

(2010) Olga A. Kovalenko et al.   PLoS One

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Structure and Organization of Mitochondrial Respiratory Complexes: A New Understanding of an Old Subject

(2009) Giorgio Lenaz et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage

(2009) Judith Haendeler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Is there more to aging than mitochondrial DNA and reactive oxygen species?

(2009) Mikhail F. Alexeyev   FEBS Journal

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells

(2008) Akihiro Naito et al.   CANCER SCIENCE

Mitochondrial DNA depletion in prostate epithelial cells promotes anoikis resistance and invasion through activation of PI3K/Akt2

(2008) L Moro et al.   CELL DEATH AND DIFFERENTIATION

Early Mitochondrial Dysfunction in Long-livedMclk1+/-Mice

(2008) Jérôme Lapointe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress

(2008) S. Ahmed et al.   JOURNAL OF CELL SCIENCE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

(2008) Marc Vermulst et al.   NATURE GENETICS

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE