Mitochondrial DNA depletion sensitizes cancer cells to PARP inhibitors by translational and post-translational repression of BRCA2

Silencing of I k Bβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo

(2012) Weigang Tang et al.   CARCINOGENESIS

Stress-Related Mitochondrial Components and Mitochondrial Genome as Targets of Anticancer Therapy

(2012) Sergio Giannattasio et al.   Chemical Biology & Drug Design

Mitochondrial DNA Mutation in Serous Ovarian Cancer: Implications for Mitochondria-Coded Genes in Chemoresistance

(2012) Flora Guerra et al.   JOURNAL OF CLINICAL ONCOLOGY

Human mitochondrial DNA: roles of inherited and somatic mutations

(2012) Eric A. Schon et al.   NATURE REVIEWS GENETICS

Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer

(2012) C C Cook et al.   Cell Death & Disease

Skp2 Overexpression Is Associated with Loss of BRCA2 Protein in Human Prostate Cancer

(2011) Arnaldo A. Arbini et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial Subversion in Cancer

(2011) A. Chatterjee et al.   Cancer Prevention Research

Placing mitochondrial DNA mutations within the progression model of type I endometrial carcinoma

(2011) Flora Guerra et al.   HUMAN MOLECULAR GENETICS

HmtDB, a genomic resource for mitochondrion-based human variability studies

(2011) Francesco Rubino et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial DNA Mutations Regulate Metastasis of Human Breast Cancer Cells

(2011) Hirotake Imanishi et al.   PLoS One

Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair

(2011) Libing Song et al.   Journal of Molecular Cell Biology

Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletion

(2010) Mariola Kulawiec et al.   CANCER BIOLOGY & THERAPY

Development of a Functional Assay for Homologous Recombination Status in Primary Cultures of Epithelial Ovarian Tumor and Correlation with Sensitivity to Poly(ADP-Ribose) Polymerase Inhibitors

(2010) A. Mukhopadhyay et al.   CLINICAL CANCER RESEARCH

Aromatase Deficiency Inhibits the Permeability Transition in Mouse Liver Mitochondria

(2010) Loredana Moro et al.   ENDOCRINOLOGY

Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2

(2010) Naihan Xu et al.   JOURNAL OF CELL BIOLOGY

Therapeutic Potential of Poly(ADP-ribose) Polymerase Inhibitor AG014699 in Human Cancers With Mutated or Methylated BRCA1 or BRCA2

(2010) Yvette Drew et al.   JNCI-Journal of the National Cancer Institute

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

(2010) M William Audeh et al.   LANCET

Activation of Akt Is Essential for the Propagation of Mitochondrial Respiratory Stress Signaling and Activation of the Transcriptional Coactivator Heterogeneous Ribonucleoprotein A2

(2010) Manti Guha et al.   MOLECULAR BIOLOGY OF THE CELL

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

(2009) Daming Gao et al.   NATURE CELL BIOLOGY

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

(2009) Hui-Kuan Lin et al.   NATURE CELL BIOLOGY

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Mitochondrial Cytochrome B Gene Mutation Promotes Tumor Growth in Bladder Cancer

(2008) S. Dasgupta et al.   CANCER RESEARCH

Mitochondrial DNA depletion in prostate epithelial cells promotes anoikis resistance and invasion through activation of PI3K/Akt2

(2008) L Moro et al.   CELL DEATH AND DIFFERENTIATION

Recovery of deficient homologous recombination in Brca2-depleted mouse cells by wild-type Rad51 expression

(2008) Shauna A. Lee et al.   DNA REPAIR

A Distinctive Physiological Role for IκBβ in the Propagation of Mitochondrial Respiratory Stress Signaling

(2008) Gopa Biswas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE