Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways
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Title
Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways
Authors
Keywords
Amino acids, Metabolism, Triple-negative, Luminal A, Stress response
Journal
BMC CANCER
Volume 18, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-06-26
DOI
10.1186/s12885-018-4599-8
References
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Note: Only part of the references are listed.- Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target
- (2016) M. Bolzoni et al. BLOOD
- Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells
- (2016) Angelika Bröer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes
- (2016) Bernard Pereira et al. Nature Communications
- Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
- (2016) Abigail S. Krall et al. Nature Communications
- Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies
- (2015) Young Joo Jeon et al. CANCER CELL
- Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer
- (2015) Mohamed Hassanein et al. INTERNATIONAL JOURNAL OF CANCER
- Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development
- (2015) Qian Wang et al. JOURNAL OF PATHOLOGY
- ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer
- (2015) M van Geldermalsen et al. ONCOGENE
- The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation
- (2014) Alfredo Csibi et al. CURRENT BIOLOGY
- Targeting glutamine transport to suppress melanoma cell growth
- (2014) Qian Wang et al. INTERNATIONAL JOURNAL OF CANCER
- ATF4 and N-Myc coordinate glutamine metabolism inMYCN-amplified neuroblastoma cells through ASCT2 activation
- (2014) Ping Ren et al. JOURNAL OF PATHOLOGY
- Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia
- (2013) L. Willems et al. BLOOD
- Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
- (2013) Luika A. Timmerman et al. CANCER CELL
- The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4
- (2013) Alfred Csibi et al. CELL
- Mammalian Target of Rapamycin Complex 1 (mTORC1) Enhances Bortezomib-induced Death in Tuberous Sclerosis Complex (TSC)-null Cells by a c-MYC-dependent Induction of the Unfolded Protein Response
- (2013) Justin T. Babcock et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis
- (2013) Atsushi Terunuma et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development
- (2013) Qian Wang et al. JNCI-Journal of the National Cancer Institute
- The SLC1 high-affinity glutamate and neutral amino acid transporter family
- (2013) Yoshikatsu Kanai et al. MOLECULAR ASPECTS OF MEDICINE
- The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
- (2013) Wafa B’chir et al. NUCLEIC ACIDS RESEARCH
- The expression of glutamine-metabolism-related proteins in breast phyllodes tumors
- (2013) Sewha Kim et al. TUMOR BIOLOGY
- ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation
- (2012) Guoliang Qing et al. CANCER CELL
- SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival
- (2012) M. Hassanein et al. CLINICAL CANCER RESEARCH
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
- (2012) Christina Curtis et al. NATURE
- Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression
- (2011) Q. Wang et al. CANCER RESEARCH
- Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis
- (2011) Mio Furuya et al. CANCER SCIENCE
- Solute Carrier Transporters as Targets for Drug Delivery and Pharmacological Intervention for Chemotherapy
- (2011) Takeo Nakanishi et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Glutamine Synthetase Is a Genetic Determinant of Cell Type–Specific Glutamine Independence in Breast Epithelia
- (2011) Hsiu-Ni Kung et al. PLoS Genetics
- The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
- (2010) Jiangbin Ye et al. EMBO JOURNAL
- Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
- (2009) Paul Nicklin et al. CELL
- ATF4-dependent transcription mediates signaling of amino acid limitation
- (2009) Michael S. Kilberg et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
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