Mahuang-Fuzi-Xixin Decoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis

Leptin Increases Expression of 5-HT2B Receptors in Astrocytes Thus Enhancing Action of Fluoxetine on the Depressive Behavior Induced by Sleep Deprivation

(2019) Xiaowei Li et al.   Frontiers in Psychiatry

Astragaloside IV ameliorates neuroinflammation-induced depressive-like behaviors in mice via the PPARγ/NF-κB/NLRP3 inflammasome axis

(2018) Mei-ting Song et al.   ACTA PHARMACOLOGICA SINICA

Asatone Prevents Acute Lung Injury by Reducing Expressions of NF-κB, MAPK and Inflammatory Cytokines

(2018) Heng-Yuan Chang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Suppression of NLRP3 inflammasome attenuates stress-induced depression-like behavior in NLGN3-deficient mice

(2018) Ze-Qun Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Principles of inflammasome priming and inhibition: Implications for psychiatric disorders

(2018) Francis J. Herman et al.   BRAIN BEHAVIOR AND IMMUNITY

Active components, derived from Kai-xin-san, a herbal formula, increase the expressions of neurotrophic factor NGF and BDNF on mouse astrocyte primary cultures via cAMP-dependent signaling pathway

(2018) Cheng Cao et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Emerging Neurobiology of Bipolar Disorder

(2018) Paul J. Harrison et al.   TRENDS IN NEUROSCIENCES

C 19 -Diterpenoid alkaloid arabinosides from an aqueous extract of the lateral root of Aconitum carmichaelii and their analgesic activities

(2018) Qinglan Guo et al.   Acta Pharmaceutica Sinica B

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation

(2018) Lige Leng et al.   NEURON

Inhibition of activated astrocyte ameliorates lipopolysaccharide- induced depressive-like behaviors

(2018) Yun Wang et al.   JOURNAL OF AFFECTIVE DISORDERS

(+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation

(2018) Yihang Zhao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress

(2018) Wen-yuan Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chemical Constituents from the Roots and Rhizomes of Asarum heterotropoides var. mandshuricum and the In Vitro Anti-Inflammatory Activity

(2017) Yu Jing et al.   MOLECULES

Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson’s disease model

(2017) Yunlong Zhang et al.   Cell Death & Disease

Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes

(2017) Si-Hao Du et al.   Frontiers in Molecular Neuroscience

Mahuang Fuzi Xixin Decoction Attenuates Th1 and Th2 Responses in the Treatment of Ovalbumin-Induced Allergic Inflammation in a Rat Model of Allergic Rhinitis

(2017) Mengyue Ren et al.   Journal of Immunology Research

Propentofylline Prevents Sickness Behavior and Depressive-Like Behavior Induced by Lipopolysaccharide in Rats via Neuroinflammatory Pathway

(2017) Márcia M. T. Moraes et al.   PLoS One

Qualitative and quantitative analysis of the chemical constituents in Mahuang-Fuzi-Xixin decoction based on high performance liquid chromatography combined with time-of-flight mass spectrometry and triple quadrupole mass spectrometers

(2016) Qihui Sun et al.   BIOMEDICAL CHROMATOGRAPHY

Wuling powder prevents the depression-like behavior in learned helplessness mice model through improving the TSPO mediated-mitophagy

(2016) Dongmei Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Mahuang-Xixin-Fuzi decoction reduces the infection of influenza A virus in Kidney-Yang deficiency syndrome mice

(2016) Rong Rong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

(2016) Monika Fleshner et al.   NEUROPSYCHOPHARMACOLOGY

Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression

(2016) Ren-Hong Du et al.   Redox Biology

PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine

(2016) Wenda Xue et al.   Scientific Reports

Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice

(2015) Hyun-Jung Park et al.   BMC Complementary and Alternative Medicine

Network pharmacology-based prediction of the active ingredients and potential targets of Mahuang Fuzi Xixin decoction for application to allergic rhinitis

(2015) Feng Tang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

(2015) Elísabet Alcocer-Gómez et al.   MOLECULAR NEUROBIOLOGY

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

Neuroimmune mechanisms of depression

(2015) Georgia E Hodes et al.   NATURE NEUROSCIENCE

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

NLRP3 Inflammasome: A New Target in Major Depressive Disorder

(2014) Elísabet Alcocer-Gómez et al.   CNS Neuroscience & Therapeutics

Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus

(2014) Xiang-Fei Meng et al.   Journal of Neuroinflammation

β-Asarone Reverses Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior and Promotes Hippocampal Neurogenesis in Rats

(2014) Haiying Dong et al.   MOLECULES

Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems

(2014) Anna Gądek-Michalska et al.   Pharmacological Reports

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity

(2013) Elke Edelmann et al.   NEUROPHARMACOLOGY

Antidepressant-like Effect of Fuzi Total Alkaloid on Ovariectomized Mice

(2012) Lei Liu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Modifiable factors that alter the size of the hippocampus with ageing

(2012) Majid Fotuhi et al.   Nature Reviews Neurology

Major depressive disorder: new clinical, neurobiological, and treatment perspectives

(2011) David J Kupfer et al.   LANCET

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

(2011) Jason S. Snyder et al.   NATURE

A pathophysiological framework of hippocampal dysfunction in ageing and disease

(2011) Scott A. Small et al.   NATURE REVIEWS NEUROSCIENCE

Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats

(2011) Zhen Huang et al.   NEUROSCIENCE LETTERS

Reward and Punishment Processing in Depression

(2010) Neir Eshel et al.   BIOLOGICAL PSYCHIATRY

Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression

(2010) Michael Maes   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Fuzi polysaccharide-1 produces antidepressant-like effects in mice

(2009) Hua-Cheng Yan et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment

(2008) Yun Li et al.   NEURON