Regulation of glutamate transporter trafficking by Nedd4-2 in a Parkinson’s disease model

Aquaporin-4 mediates communication between astrocyte and microglia: Implications of neuroinflammation in experimental Parkinson’s disease

(2016) H. Sun et al.   NEUROSCIENCE

NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins

(2015) Pranay Goel et al.   GENE

Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

(2015) Fabienne C. Fiesel et al.   HUMAN MUTATION

Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes

(2015) G. T. Petr et al.   JOURNAL OF NEUROSCIENCE

Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease

(2015) Joannee Zumkehr et al.   NEUROBIOLOGY OF AGING

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

(2015) Victor S. Van Laar et al.   NEUROBIOLOGY OF DISEASE

Blockade of the GLT-1 Transporter in the Central Nucleus of the Amygdala Induces both Anxiety and Depressive-Like Symptoms

(2015) Catherine S John et al.   NEUROPSYCHOPHARMACOLOGY

Effects of ceftriaxone on the behavioral and neuronal changes in an MPTP-induced Parkinson's disease rat model

(2014) Shih-Chun Ho et al.   BEHAVIOURAL BRAIN RESEARCH

Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein

(2014) Naoto Sugeno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection

(2014) Qiongman Kong et al.   JOURNAL OF CLINICAL INVESTIGATION

Ceftriaxone Protects Astrocytes from MPP+ via Suppression of NF-κB/JNK/c-Jun Signaling

(2014) Yunlong Zhang et al.   MOLECULAR NEUROBIOLOGY

Ubiquitination in disease pathogenesis and treatment

(2014) Doris Popovic et al.   NATURE MEDICINE

New insights into ubiquitin E3 ligase mechanism

(2014) Christopher E Berndsen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat substantia nigra

(2014) Maxime Assous et al.   NEUROBIOLOGY OF DISEASE

Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis

(2014) Natasha Chaudhary et al.   PLOS BIOLOGY

Ceftriaxone Blocks the Polymerization of α-Synuclein and Exerts Neuroprotective Effects in Vitro

(2013) Paolo Ruzza et al.   ACS Chemical Neuroscience

Striatal glutamate induces retrograde excitotoxicity and neuronal degeneration of intralaminar thalamic nuclei: their potential relevance for Parkinson's disease

(2013) Ingrid Morales et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

(2013) D. F. Tardiff et al.   SCIENCE

Monoubiquitination of EEA1 regulates endosome fusion and trafficking

(2013) Harish N Ramanathan et al.   Cell and Bioscience

Transient striatal GLT-1 blockade increases EAAC1 expression, glutamate reuptake, and decreases tyrosine hydroxylase phosphorylation at ser19

(2012) Michael F. Salvatore et al.   EXPERIMENTAL NEUROLOGY

Cell surface turnover of the glutamate transporter GLT-1 is mediated by ubiquitination/deubiquitination

(2012) Jaime Martínez-Villarreal et al.   GLIA

Protein Kinase C (PKC)-promoted Endocytosis of Glutamate Transporter GLT-1 Requires Ubiquitin Ligase Nedd4-2-dependent Ubiquitination but Not Phosphorylation

(2012) Noemí García-Tardón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protective effect of extract of Acanthopanax senticosus harms on dopaminergic neurons in Parkinson's disease mice

(2012) Shu-min Liu et al.   PHYTOMEDICINE

Ceftriaxone Ameliorates Motor Deficits and Protects Dopaminergic Neurons in 6-Hydroxydopamine-Lesioned Rats

(2011) T. C. H. Leung et al.   ACS Chemical Neuroscience

Disruption of Eaat2b, a glutamate transporter, results in abnormal motor behaviors in developing zebrafish

(2011) Kelly Anne McKeown et al.   DEVELOPMENTAL BIOLOGY

Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability

(2011) Syama Sundar Boyalla et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ubiquitin ligase Nedd4 promotes  -synuclein degradation by the endosomal-lysosomal pathway

(2011) G. K. Tofaris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired glutamate homeostasis and programmed cell death in a chronic MPTP mouse model of Parkinson's disease

(2009) G.E. Meredith et al.   EXPERIMENTAL NEUROLOGY

The Activity of the Epithelial Sodium Channels Is Regulated by Caveolin-1 via a Nedd4-2-dependent Mechanism

(2009) Il-Ha Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid Rafts and Caveolin-1 Coordinate Interleukin-1β (IL-1β)-dependent Activation of NFκB by Controlling Endocytosis of Nox2 and IL-1β Receptor 1 from the Plasma Membrane

(2009) Fredrick D. Oakley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

(2009) Hui Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Enhancement of glutamate uptake in 1-methyl-4-phenylpyridinium-treated astrocytes by trichostatin A

(2009) Jia-Yong Wu et al.   NEUROREPORT

Caveolin-1-dependent  1 integrin endocytosis is a critical regulator of fibronectin turnover

(2008) F. Shi et al.   JOURNAL OF CELL SCIENCE

Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6-hydroxydopamine-lesioned rats

(2008) E.K.Y. Chung et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Internalization and degradation of the glutamate transporter GLT-1 in response to phorbol ester

(2007) Bala T.S. Susarla et al.   NEUROCHEMISTRY INTERNATIONAL