Combined effects of thePNPLA3rs738409,TM6SF2rs58542926, andMBOAT7rs641738 variants on NAFLD severity: a multicenter biopsy-based study

Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level1,2

(2016) Silvia Sookoian et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis

(2016) Jia-Hao Fan et al.   Gut and Liver

Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes

(2016) Mohammed Eslam et al.   HEPATOLOGY

Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice

(2016) Giulio Marchesini et al.   HEPATOLOGY

TM6SF2 may drive postprandial lipoprotein cholesterol toxicity away from the vessel walls to the liver in NAFLD

(2016) Giovanni Musso et al.   JOURNAL OF HEPATOLOGY

PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery

(2016) Marcin Krawczyk et al.   Surgery for Obesity and Related Diseases

MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C

(2016) Khaled Thabet et al.   Nature Communications

PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease

(2015) Habeeb Salameh et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2015) Paul Angulo et al.   GASTROENTEROLOGY

The dual and opposite role of theTM6SF2-rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta-analysis

(2015) Carlos J. Pirola et al.   HEPATOLOGY

Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients

(2015) Marta Milano et al.   HEPATOLOGY

Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity

(2015) Silvia Sookoian et al.   HEPATOLOGY

Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2

(2015) You Zhou et al.   JOURNAL OF HEPATOLOGY

The commonPNPLA3variant p.I148M is associated with liver fat contents as quantified by controlled attenuation parameter (CAP)

(2015) Anita Arslanow et al.   LIVER INTERNATIONAL

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

(2015) Stephan Buch et al.   NATURE GENETICS

The Genetics of Nonalcoholic Fatty Liver Disease: Spotlight on PNPLA3 and TM6SF2

(2015) Christopher Day et al.   SEMINARS IN LIVER DISEASE

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors

(2014) Paola Dongiovanni   WORLD JOURNAL OF GASTROENTEROLOGY

PNPLA3-Associated Steatohepatitis: Toward a Gene-Based Classification of Fatty Liver Disease

(2013) Marcin Krawczyk et al.   SEMINARS IN LIVER DISEASE

The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology

(2012) Naga Chalasani et al.   GASTROENTEROLOGY

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

(2011) Silvia Sookoian et al.   HEPATOLOGY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS